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    CONTROLLABLE SELF-ANNEALING MICROGEL PARTICLES FOR BIOMEDICAL APPLICATIONS
    3.
    发明公开
    CONTROLLABLE SELF-ANNEALING MICROGEL PARTICLES FOR BIOMEDICAL APPLICATIONS 审中-公开
    用于生物医学应用的可控自退火微粒

    公开(公告)号：EP3169372A1

    公开(公告)日：2017-05-24

    申请号：EP15821310.8

    申请日：2015-07-17

    申请人： The Regents of the University of California

    发明人： GRIFFIN, Donald R. ,  WEAVER, Westbrook ,  SEGURA, Tatiana ,  DI CARLO, Dino ,  SCUMPIA, Philip

    IPC分类号： A61L15/42 ,  A61L15/44 ,  A61L15/60

    CPC分类号： A61L26/008 ,  A61L26/0019 ,  A61L26/0047 ,  A61L26/0066 ,  A61L26/0085 ,  A61L26/009 ,  A61L27/18 ,  A61L27/227 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2400/06 ,  A61L2430/00 ,  A61L2430/34 ,  C08L71/02

    摘要： A microporous gel system for certain applications, including biomedical applications, includes an aqueous solution containing plurality of microgel particles including a biodegradable crosslinker. In some aspects, the microgel particles act as gel building blocks that anneal to one another to form a covalently-stabilized scaffold of microgel particles having interstitial spaces therein. In certain aspects, annealing of the microgel particles occurs after exposure to an annealing agent that is endogenously present or exogenously added. In some embodiments, annealing of the microgel particles requires the presence of an initiator such as exposure to light. In particular embodiments, the chemical and physical properties of the gel building blocks can be controlled to allow downstream control of the resulting assembled scaffold. In one or more embodiments, cells are able to quickly infiltrate the interstitial spaces of the assembled scaffold.

    摘要翻译： 用于某些应用（包括生物医学应用）的微孔凝胶系统包括含有多个包含生物可降解交联剂的微凝胶颗粒的水溶液。 在一些方面，微凝胶颗粒充当彼此退火以形成其中具有间隙空间的微凝胶颗粒的共价稳定支架的凝胶构建块。 在某些方面，微凝胶颗粒的退火发生在暴露于内源性存在或外源添加的退火剂之后。 在一些实施方案中，微凝胶颗粒的退火需要存在引发剂，例如暴露于光下。 在具体的实施方案中，可以控制凝胶构建块的化学和物理性质以允许下游控制所得到的组装支架。 在一个或多个实施方案中，细胞能够快速渗入组装好的支架的间隙空间。