公开(公告)号：EP2373995A2

公开(公告)日：2011-10-12

申请号：EP09836648.7

申请日：2009-12-02

申请人： The Regents of the University of California ,  The University Of Maryland

发明人： EMERSON, Jane ,  SUN, Kunshan ,  RAGHAVAN, Srinivasa

IPC分类号： G01N33/49 ,  C12Q1/24 ,  C12M1/24 ,  C12M1/10 ,  A61B5/15

CPC分类号： B01L3/50215 ,  B01D21/26 ,  B01L3/5021 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2300/0832 ,  B01L2300/12 ,  B01L2300/1861 ,  B01L2400/0409 ,  B01L2400/0677 ,  B01L2400/086 ,  G01N33/491

摘要： Contemplated compositions and methods allow for in-situ formation of a rigid seal layer in a blood collection tube between a cell-depleted phase and a cell-enriched phase. Preferably, the seal layer is formed upon brief UV irradiation and comprises an acrylate, a methacrylate, an epoxy, a urethane, and/or a thiol-ene polymer.

公开(公告)号：EP2229237A1

公开(公告)日：2010-09-22

申请号：EP08844203.3

申请日：2008-10-13

申请人： The Regents of the University of California

发明人： EMERSON, Jane

IPC分类号： B04B11/06

CPC分类号： B01D21/262 ,  B01D21/26 ,  B01L3/50215 ,  B01L2200/12 ,  B01L2400/0677

摘要： Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The barrier rapidly hardens forming a solid barrier when triggered by a suitable energy source.

公开(公告)号：EP2346983A2

公开(公告)日：2011-07-27

申请号：EP09826538.2

申请日：2009-10-27

申请人： The Regents of the University of California

发明人： EMERSON, Jane

IPC分类号： C12M1/24 ,  A61B5/15 ,  G01N33/49

CPC分类号： B01L3/50215 ,  B01D21/26 ,  B01D21/262 ,  B01L2200/12 ,  B01L2400/0677 ,  G01N1/4077 ,  G01N2001/4083

摘要： Methods of producing collection tubes are presented. The methods include providing a separator substance that can rapidly polymerize in a short time to a desired hardness and disposing the separator substance within the lumen of the tube. The separator substance is formulated to have a density between an average density of a serum fraction of whole blood and a cell-containing fraction of whole blood, and to be flowable with whole blood. Upon centrifugation of a tube having blood, the separator substance forms a barrier between the whole blood fractions. The tube and barrier maintain stability of one or more analyte levels, including potassium and glucose, within 10% of their initial values before centrifugation for at least four days.