公开(公告)号：EP2468711A2

公开(公告)日：2012-06-27

申请号：EP12000444.5

申请日：2005-01-21

Applicant: The Trustees Of The University Of Pennsylvania

Inventor： Degrado, William, F. ,  Liu, Dahui ,  Tew, Gregory, N. ,  Klein, Michael, L.

IPC: C07C211/00 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78 ,  C07C279/12

CPC classification number: C07C279/12 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78

Abstract: The present invention discloses facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers of formula (Ia), compositions thereof, preparation thereof and their use as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy

        R 1 -A 1 -s-A 2 -s-A 1 -R 2      Formula (Ia)

wherein A 1 and A 2 are independently substituted or unsubstituted arylene or heteroarylene, s is absent, or -CH=CH- or C≡C- and R 1 and R 2 are as defined in claim 1. Examples of compounds of formula (Ia) are the following

Abstract translation: 本发明公开了式（Ia）的表面两亲聚芳基和聚芳基炔基聚合物和低聚物，其组合物，其制备及其作为抗微生物剂的用途以及用于与肝素治疗相关的出血并发症的解毒剂。€ƒ€ƒ€ƒ€ ƒ€ƒ€ƒR1 -A 1 -sA 2 -sA 1 -R 2€ƒ€ƒ€ƒ€ƒFormula（Ia）其中A 1和A 2独立地是取代或未取代的亚芳基或亚杂芳基，s不存在， 或-CH = CH-或C≡C-并且R 1和R 2如权利要求1中所定义。式（Ia）化合物的实例如下

公开(公告)号：EP2471526A3

公开(公告)日：2012-12-12

申请号：EP12000364.5

申请日：2004-03-17

Applicant: The Trustees Of The University Of Pennsylvania

Inventor： Degrado, William, F. ,  Liu, Dahui ,  Tew, Gregory, N. ,  Klein, Michael, L. ,  Yuan, Jing ,  Choi, Sungwook

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/495 ,  C07C233/64 ,  C07C323/42 ,  C07C323/44 ,  C08G18/32 ,  C08G73/02 ,  C08L75/02 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P39/02

CPC classification number: A61K31/17 ,  A61K31/16 ,  A61K31/165 ,  A61K31/495 ,  C07C233/64 ,  C07C323/42 ,  C07C323/44 ,  C08G18/3225 ,  C08G73/028 ,  C08L75/02

Abstract: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.

公开(公告)号：EP2468711A3

公开(公告)日：2012-09-19

申请号：EP12000444.5

申请日：2005-01-21

Applicant: The Trustees Of The University Of Pennsylvania

Inventor： Degrado, William, F. ,  Liu, Dahui ,  Tew, Gregory, N. ,  Klein, Michael, L.

IPC: C07C211/00 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78 ,  C07C279/12

CPC classification number: C07C279/12 ,  A61K31/74 ,  C07C211/27 ,  C07C217/58 ,  C07C233/78

Abstract: The present invention discloses facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers of formula (Ia), compositions thereof, preparation thereof and their use as antimicrobial agents and as antidotes for hemorrhagic complications associated with heparin therapy

        R 1 -A 1 -s-A 2 -s-A 1 -R 2      Formula (Ia)

wherein A 1 and A 2 are independently substituted or unsubstituted arylene or heteroarylene, s is absent, or -CH=CH- or C≡C- and R 1 and R 2 are as defined in claim 1. Examples of compounds of formula (Ia) are the following

公开(公告)号：EP2471526A2

公开(公告)日：2012-07-04

申请号：EP12000364.5

申请日：2004-03-17

Applicant: The Trustees Of The University Of Pennsylvania

Inventor： Degrado, William, F. ,  Liu, Dahui ,  Tew, Gregory, N. ,  Klein, Michael, L. ,  Yuan, Jing ,  Choi, Sungwook

IPC: A61K31/16 ,  A61K31/495 ,  C07C233/64 ,  C07C323/42 ,  C07C323/44 ,  C08G18/32 ,  C08G73/02 ,  C08L75/02 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P39/02

CPC classification number: A61K31/17 ,  A61K31/16 ,  A61K31/165 ,  A61K31/495 ,  C07C233/64 ,  C07C323/42 ,  C07C323/44 ,  C08G18/3225 ,  C08G73/028 ,  C08L75/02

Abstract: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.

公开(公告)号：EP2289524A1

公开(公告)日：2011-03-02

申请号：EP10009912.6

申请日：2002-03-07

Applicant: The Trustees Of The University Of Pennsylvania

Inventor： Degrado, William, F. ,  Tew, Gregory, N. ,  Klein, Michael, L.

IPC: A61K31/74 ,  A01N25/34 ,  A01N33/10 ,  A01N43/10 ,  A01N43/36

CPC classification number: A61L15/44 ,  A01N25/10 ,  A01N37/18 ,  A01N37/22 ,  A01N37/24 ,  A01N37/28 ,  A01N37/30 ,  A01N37/42 ,  A01N47/22 ,  A01N47/30 ,  A01N47/44 ,  A61K31/74 ,  A61L27/54 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/20 ,  A61L2300/216 ,  A61L2300/404 ,  C08G18/2865 ,  C08G18/3225 ,  C08G61/02 ,  C08G61/10 ,  C08G61/122 ,  C08G69/26 ,  C08G73/028 ,  C08G73/22 ,  C08G2261/312 ,  Y10T428/193 ,  Y10T428/24207 ,  Y10T428/24446 ,  Y10T428/24455 ,  Y10T428/29 ,  Y10T428/31 ,  Y10T428/31504 ,  Y10T428/31678 ,  Y10T428/31725 ,  Y10T428/8305

Abstract: Facially amphiphilic polyphenylene and heteroarylene polymers and articles made there from having biocidal surfaces are disclosed. The polymers can inhibit the growth of microorganisms in contact with the surface or in areas adjacent to said biocidal surface. There is also disclosed a methods to attach facially amphiphilic polymers to a solid support. Utility as a contact disinfectant is disclosed.

Abstract translation: 公开了两亲性聚亚苯基和杂亚芳基聚合物和在其上制备的具有杀生物表面的制品。 聚合物可以抑制与表面或邻近所述杀生物表面的区域接触的微生物的生长。 还公开了将表面两亲聚合物附着到固体支持物上的方法。 公开了作为接触消毒剂的效用。