公开(公告)号：EP3271389B8

公开(公告)日：2020-04-22

申请号：EP16716979.6

申请日：2016-03-18

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  KANG, Byong, Ha ,  MASCOLA, John ,  ISHIDA, Elise ,  ZHOU, Tongqing ,  KWONG, Peter ,  ZHENG, Anqi

IPC分类号： C07K16/10 ,  A61P31/18

公开(公告)号：EP3271389B1

公开(公告)日：2020-02-12

申请号：EP16716979.6

申请日：2016-03-18

申请人： The United States of America, as Represented by the Secretary Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  KANG, Byong, Ha ,  MASCOLA, John ,  ISHIDA, Elise ,  ZHOU, Tongqing ,  KWONG, Peter ,  ZHENG, Anqi

IPC分类号： C07K16/10 ,  A61P31/18

公开(公告)号：EP2776463A1

公开(公告)日：2014-09-17

申请号：EP12847241.2

申请日：2012-11-07

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  LAUB, Leo, B. ,  KWONG, Peter ,  NABEL, Gary ,  MASCOLA, John, R. ,  ZHANG, Baoshan ,  RUDICELL, Rebecca, S. ,  GEORGIEV, Ivelin ,  YANG, Yongping ,  ZHU, Jiang ,  OFEK, Gilad

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/18 ,  C12N15/13

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  A61K49/0004 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/1045 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/56988 ,  G01N2333/161

摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.

摘要翻译： 公开了特异性结合HIV-1 gp41膜近端外部区域（MPER）的单克隆中和抗体。 还公开了包括所公开的特异性结合gp41的抗体，编码这些抗体的核酸，包括核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 本文公开的抗体和组合物可用于检测生物样品中HIV-1的存在，或检测受试者中的HIV-1感染或AIDS的诊断。 此外，所公开抗体的广泛中和宽度使其成为治疗HIV感染的受试者的理想选择。 因此，公开了治疗和/或预防HIV感染的方法。

公开(公告)号：EP3271389A1

公开(公告)日：2018-01-24

申请号：EP16716979.6

申请日：2016-03-18

申请人： The United States of America, as Represented by the Secretary Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  KANG, Byong, Ha ,  MASCOLA, John ,  ISHIDA, Elise ,  ZHOU, Tongqing ,  KWONG, Peter ,  ZHENG, Anqi

IPC分类号： C07K16/10 ,  A61P31/18

CPC分类号： C07K16/1063 ,  A61K2039/505 ,  A61K2039/545 ,  A61P31/18 ,  C07K16/2809 ,  C07K16/468 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/76 ,  G01N33/56988 ,  G01N2333/162 ,  G01N2800/26

摘要： Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：EP2776463B1

公开(公告)日：2017-09-20

申请号：EP12847241.2

申请日：2012-11-07

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： CONNORS, Mark ,  HUANG, Jinghe ,  LAUB, Leo, B. ,  KWONG, Peter ,  NABEL, Gary ,  MASCOLA, John, R. ,  ZHANG, Baoshan ,  RUDICELL, Rebecca, S. ,  GEORGIEV, Ivelin ,  YANG, Yongping ,  ZHU, Jiang ,  OFEK, Gilad

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/18 ,  C12N15/13

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  A61K49/0004 ,  A61K2039/505 ,  C07K16/00 ,  C07K16/1045 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  G01N33/56972 ,  G01N33/56983 ,  G01N33/56988 ,  G01N2333/161

摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection.

摘要翻译： 公开了单克隆中和抗体，其特异性结合HIV-1 gp41膜近端外部区域（MPER）。 还公开了包含特异性结合gp41的公开抗体，编码这些抗体的核酸，包含核酸的表达载体和表达核酸的分离的宿主细胞的组合物。 本文公开的抗体和组合物可用于检测生物样品中HIV-1的存在，或检测受试者中的HIV-1感染或诊断AIDS。 另外，所公开的抗体的广泛中和宽度使得它们理想地用于治疗HIV感染的受试者。 因此，公开了治疗和/或预防HIV感染的方法。