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公开(公告)号：EP3038641B1
公开(公告)日：2019-04-17
申请号：EP14789449.7
申请日：2014-10-03
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , F. Hoffmann-La Roche AG
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , LEE, Byungkook , NIEDERFELLNER, Gerhard , IMHOF-JUNG, Sabine , BRINKMANN, Ulrich , GEORGES, Guy
IPC分类号： C07K14/21 , A61K38/00 , A61K39/395 , C07K16/30 , A61K47/68 , A61K38/16 , C07K16/12 , A61K39/00 , C07K16/40 , A61K31/337
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公开(公告)号：EP3038641A2
公开(公告)日：2016-07-06
申请号：EP14789449.7
申请日：2014-10-03
申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services , F. Hoffmann-La Roche AG
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , LEE, Byungkook , NIEDERFELLNER, Gerhard , IMHOF-JUNG, Sabine , BRINKMANN, Ulrich , SCHEUER, Werner , GEORGES, Guy
CPC分类号： C07K16/30 , A61K31/337 , A61K38/00 , A61K39/39558 , A61K47/6803 , A61K47/6829 , A61K47/6851 , A61K47/6859 , A61K47/6871 , A61K2039/505 , C07K14/21 , C07K16/1214 , C07K16/303 , C07K16/40 , C07K2317/24 , C07K2317/55 , C07K2317/624 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/33 , C07K2319/50 , C07K2319/55 , A61K2300/00
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 本发明还提供了哺乳动物治疗或预防癌症的方法，抑制靶细胞生长的方法，生产PE的方法和嵌合分子的制备方法。
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3.发明公开PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES 审中-公开具有较少免疫原性T细胞和/或B细胞表位的假单胞菌外毒素A
公开(公告)号：EP3231812A1
公开(公告)日：2017-10-18
申请号：EP17163568.3
申请日：2012-06-07
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , VASSALL, Aaron , BEERS, Richard , EBERLE, Jaime , LIU, Wenhai
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明进一步提供了相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 本发明进一步提供了治疗或预防哺乳动物癌症的方法，抑制靶细胞生长的方法，生产PE的方法以及生产嵌合分子的方法。
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4.发明授权PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES 有权PSEUDOMONAS EXOTOXIN A MIT WENIGER IMMUNOGENEN T-ZELL-UND / ODER B-ZELLEPITOPEN
公开(公告)号：EP2718308B1
公开(公告)日：2017-05-17
申请号：EP12727074.2
申请日：2012-06-07
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , VASSALL, Aaron , BEERS, Richard , EBERLE, Jaime , LIU, Wenhai
CPC分类号： C07K14/21 , A61K38/00 , C07K16/2896 , C07K2319/33 , C07K2319/55
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
摘要翻译： 本发明提供了包含具有一个或多个B细胞和/或T细胞表位取代的氨基酸序列的假单胞菌外毒素A（PE）。 本发明还提供相关的嵌合分子以及相关的核酸，重组表达载体，宿主细胞，细胞群和药物组合物。 本发明还提供了哺乳动物治疗或预防癌症的方法，抑制靶细胞生长的方法，生产PE的方法和嵌合分子的制备方法。
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公开(公告)号：EP3231812B1
公开(公告)日：2020-03-25
申请号：EP17163568.3
申请日：2012-06-07
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , VASSALL, Aaron , BEERS, Richard , EBERLE, Jaime , LIU, Wenhai
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6.发明公开PSEUDOMONAS EXOTOXIN A WITH LESS IMMUNOGENIC T CELL AND/OR B CELL EPITOPES 有权假单胞菌外毒素A的免疫原性更低的T细胞和/或B细胞表位
公开(公告)号：EP2718308A1
公开(公告)日：2014-04-16
申请号：EP12727074.2
申请日：2012-06-07
发明人： PASTAN, Ira H. , MAZOR, Ronit , ONDA, Masanori , VASSALL, Aaron , BEERS, Richard , EBERLE, Jaime , LIU, Wenhai
CPC分类号： C07K14/21 , A61K38/00 , C07K16/2896 , C07K2319/33 , C07K2319/55
摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.
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