公开(公告)号：EP4421177A2

公开(公告)日：2024-08-28

申请号：EP24174501.7

申请日：2014-03-13

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： BOYINGTON, Jeffrey ,  GEORGIEV, Ivelin, Stefanov ,  PANCERA, Marie ,  SOTO, Cinque ,  SRIVATSAN, Sanjay ,  STEWART-JONES, Guillaume ,  KWONG, Peter, D. ,  GRAHAM, Barney, S. ,  MCLELLAN, Jason, S. ,  JOYCE, Michael, Gordon ,  KANEKIYO, Masaru ,  ZHANG, Baoshan ,  CHEN, Lei ,  CHEN, Man ,  CHUANG, Gwo-Yu ,  GORMAN, Jason ,  YANG, Yongping ,  ZHOU, Tongqing ,  SASTRY, Mallika ,  OFEK, Gilad

IPC分类号： C12N15/62

CPC分类号： A61K39/155 ,  A61K2039/5320130101 ,  A61K2039/5556120130101 ,  A61K2039/5556620130101 ,  C12N2760/1853420130101 ,  A61K2039/525220130101 ,  A61K2039/525420130101 ,  A61K2039/54320130101 ,  A61K2039/5550520130101 ,  C12N2710/1034320130101 ,  A61K39/12 ,  C07K2319/2120130101 ,  C07K2319/2220130101 ,  C07K2319/5020130101 ,  C07K2319/7020130101 ,  C07K2319/73520130101 ,  C12N2760/1852220130101 ,  C07K14/005 ,  A61P31/14 ,  A61P43/00

摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

公开(公告)号：EP2970398A1

公开(公告)日：2016-01-20

申请号：EP14775224.0

申请日：2014-03-13

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： BOYINGTON, Jeffrey ,  GEORGIEV, Ivelin, Stefanov ,  PANCERA, Marie ,  SOTO, Cinque ,  SRIVATSAN, Sanjay ,  STEWART-JONES, Guillaume ,  KWONG, Peter, D. ,  GRAHAM, Barney, S. ,  MCLELLAN, Jason, S. ,  JOYCE, Michael, Gordon ,  KANEKIYO, Masaru ,  ZHANG, Baoshan ,  CHEN, Lei ,  CHEN, Man ,  CHUANG, Gwo-Yu ,  GORMAN, Jason ,  YANG, Yongping ,  ZHOU, Tongqing ,  SASTRY, Mallika ,  OFEK, Gilad

IPC分类号： C07K14/135 ,  A61K39/00 ,  A61K39/155 ,  A61K38/10 ,  A61P43/00 ,  C12N15/45 ,  C12N15/62

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/53 ,  A61K2039/543 ,  A61K2039/55505 ,  A61K2039/55561 ,  A61K2039/55566 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/50 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N2710/10343 ,  C12N2760/18522 ,  C12N2760/18534 ,  G01N33/564

摘要： Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.

摘要翻译： 公开了呼吸道合胞病毒（RSV）抗原，包括以融合前构象稳定的重组RSV F蛋白。 还公开了编码抗原的核酸和生产抗原的方法。 还公开了在受试者中产生免疫应答的方法。 在一些实施方案中，该方法是通过将治疗有效量的抗原给予受试者来治疗或预防受试者中的RSV感染的方法。