公开(公告)号：EP3189067A1

公开(公告)日：2017-07-12

申请号：EP15766697.5

申请日：2015-09-04

申请人： The United States of America, as represented by The Secretary, Department of Health and Human Services

发明人： KWONG, Peter ,  PANCERA, Marie ,  ZHOU, Tongqing ,  GEORGIEV, Ivelin ,  JOYCE, Michael Gordon ,  ACHARYA, Priyamvada ,  GORMAN, Jason ,  YANG, Yongping ,  DRUZ, Aliaksandr ,  STEWART-JONES, Guillaume ,  CHEN, Rita ,  CHUANG, Gwo-Yu ,  CHENG, Cheng ,  BAXA, Ulrich ,  MASCOLA, John ,  LYNCH, Rebecca ,  ZHANG, Baoshan

IPC分类号： C07K14/16 ,  A61K39/21 ,  C12N15/49 ,  C12N5/10

CPC分类号： C07K14/435 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55577 ,  C07K14/005 ,  C07K16/1063 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16122 ,  C12N2740/16134 ,  G01N33/56988 ,  G01N2333/162 ,  G01N2469/20

摘要： HIV-1 Env ectodomain trimers stabilized in a prefusion mature closed conformation and methods of their use and production are disclosed. In several embodiments, the HIV-1 Env ectodomain trimers and/or nucleic acid molecules can be used to generate an immune response to HIV-1 in a subject. In additional embodiments, the therapeutically effective amount of the HIV-1 Env ectodomain trimers can be administered to a subject in a method of treating or preventing HIV-1 infection.

摘要翻译： 公开了在融合前成熟闭合构象中稳定的HIV-1环境外三聚体及其使用和生产方法。 在几个实施方案中，HIV-1内源结构域三聚体和/或核酸分子可用于在受试者体内产生对HIV-1的免疫应答。 在另外的实施方案中，治疗有效量的HIV-1内源结构域三聚体可以在治疗或预防HIV-1感染的方法中施用于受试者。

公开(公告)号：EP1737885A2

公开(公告)日：2007-01-03

申请号：EP05778761.6

申请日：2005-04-12

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  GENVEC, INC.

发明人： NABEL, Gary, J. ,  CHENG, Cheng ,  KONG, Wing-Pui ,  GALL, Jason, G., D. ,  KING, C., Richter

IPC分类号： C07K14/16

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/57 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2740/16134 ,  C12N2740/16222 ,  C12N2740/16234

摘要： The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively.

公开(公告)号：EP1802762A2

公开(公告)日：2007-07-04

申请号：EP05812347.2

申请日：2005-10-17

申请人： GENVEC, INC. ,  THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： KING, C., Richter ,  GALL, Jason, G., D. ,  NABEL, Gary, J. ,  CHENG, Cheng

IPC分类号： C12N15/86

CPC分类号： A61K39/0011 ,  A61K39/385 ,  A61K47/64 ,  A61K47/646 ,  A61K2039/53 ,  A61K2039/6075 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/10322 ,  Y02A50/386 ,  Y02A50/412

摘要： The invention provides a gene transfer vector and a conjugate comprising at least three contiguous amino acids of a shaft region of a subgroup C adenovirus fiber protein. The invention also provides methods of using the gene transfer vector and the conjugate to induce an immune response in a mammal, and to deliver a protein or a non-proteinaceous molecule to a specific cell type.

公开(公告)号：EP3697440A1

公开(公告)日：2020-08-26

申请号：EP18808145.9

申请日：2018-10-16

申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： KWONG, Peter ,  MASCOLA, John ,  CHUANG, Gwo-Yu ,  GENG, Hui ,  YANG, Yongping ,  CHENG, Cheng ,  BOYINGTON, Jeffrey ,  LAI, Yen-Ting

IPC分类号： A61K39/21 ,  C07K14/16