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    PH-SENSITIVE FLUORESCENT PROBE
    3.
    发明公开
    PH-SENSITIVE FLUORESCENT PROBE 有权
    PH-WERT-EMPFINDLICHE FLUORESZIERENDE SONDE

    公开(公告)号：EP2098529A1

    公开(公告)日：2009-09-09

    申请号：EP07831889.6

    申请日：2007-11-15

    申请人： The University of Tokyo

    发明人： NAGANO, Tetsuo ,  URANO, Yasuteru ,  ASANUMA, Daisuke

    IPC分类号： C07F5/02 ,  G01N21/64 ,  G01N21/78

    CPC分类号： C07F5/022 ,  G01N21/80

    摘要： A compound represented by the following general formula (I):

    wherein R 1 represents an amino group which may be substituted with one or two alkyl groups; R 2 , R 3 , R 4 and R 5 independently represent an alkyl group; and R 6 and R 7 independently represent a monocarboxyalkyl group, a salt thereof, or an ester thereof, which is useful as a pH-sensitive fluorescent probe which emits intense fluorescence in an acidic region.

    摘要翻译： 由以下通式（I）表示的化合物：其中R 1表示可被一个或两个烷基取代的氨基; R 2，R 3，R 4和R 5独立地表示烷基; R 6和R 7独立地表示单羧基烷基，其盐或其酯，其可用作在酸性区域发射强荧光的pH敏感荧光探针。

    FLUORESCENT PROBE FOR USE IN MEASUREMENT OF PROTEASE
    9.
    发明公开
    FLUORESCENT PROBE FOR USE IN MEASUREMENT OF PROTEASE 有权
    FLUORESZENZSONDEFÜRPROTEASEMESSUNG

    公开(公告)号：EP2399920A1

    公开(公告)日：2011-12-28

    申请号：EP10743579.4

    申请日：2010-02-19

    申请人： The University of Tokyo

    发明人： NAGANO, Tetsuo ,  URANO, Yasuteru ,  SAKABE, Masayo

    IPC分类号： C07D493/10 ,  G01N21/78

    CPC分类号： C07D493/10 ,  C09B11/24

    摘要： A compound represented by the formula (I) or a salt thereof (R 1 represents hydrogen atom, or a substituent; R 2 to R 7 represent hydrogen atom, hydroxyl group, an alkyl group, or a halogen atom; R 8 and R 9 represent hydrogen atom, or an alkyl group; X represents a C 1 -C 3 alkylene group; and R 10 represents an acyl group), which promptly causes a structural change from a non-fluorescent closed ring structure to a strongly fluorescent open ring structure by hydrolysis of an acyl group, and is useful as a fluorescent probe for measuring a protease showing superior suitability for quantification.

    摘要翻译： 由式（I）表示的化合物或其盐（R 1表示氢原子或取代基; R 2至R 7表示氢原子，羟基，烷基或卤素原子; R 8和R 9 表示氢原子或烷基; X表示C 1 -C 3亚烷基; R 10表示酰基），其迅速导致从非荧光闭环结构向强荧光开环结构的结构变化 通过水解酰基，可用作荧光探针，用于测定显示出优异的定量适用性的蛋白酶。

    TUMOR-SELECTIVE FLUORESCENT DYE
    10.
    发明公开
    TUMOR-SELECTIVE FLUORESCENT DYE 审中-公开
    TUMORSELEKTIVER FLUORESZIERENDER FARBSTOFF

    公开(公告)号：EP1990063A1

    公开(公告)日：2008-11-12

    申请号：EP07714959.9

    申请日：2007-02-27

    申请人： The University of Tokyo

    发明人： NAGANO, Tetsuo ,  URANO, Yasuteru ,  KOJIMA, Hirotatsu ,  FUJIKAWA, Yuuta ,  TAKAMATSU, Tetsuro ,  HARADA, Yoshinori

    IPC分类号： A61K49/00 ,  C07D493/10

    CPC分类号： C07D493/10 ,  A61K49/0043 ,  A61K49/0052

    摘要： [Object] To provide a staining agent that is capable of achieving selective fluorescent staining of a tumor cell or a tumor tissue.
    [Means to Achieve the Object] A tumor cell or tumor tissue-selective fluorescent staining agent comprising a compound represented by the following general formula (I):

    wherein R 1 and R 2 independently represent a C 1 -C 4 alkyl group which may be substituted, a C 2 -C 4 alkenyl group which may be substituted, a C 2 -C 4 alkynyl group which may be substituted, an aryl group which may be substituted, or a heteroaryl group which may be substituted.

    摘要翻译： 提供能够实现肿瘤细胞或肿瘤组织的选择性荧光染色的染色剂。 实现目标的手段包含由以下通式（I）表示的化合物的肿瘤细胞或肿瘤组织选择性荧光染色剂：其中R 1和R 2独立地表示C 1 -C 4烷基，其可以是 可被取代的C 2〜C 4烯基，可被取代的C 2〜C 4炔基，可被取代的芳基或可被取代的杂芳基。