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1.发明公开Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound 有权Ktistalline形式einer 4- [2-（2- Fluorphenoxymethyl）苯基] piperidinverbindung
公开(公告)号：EP2358676A1
公开(公告)日：2011-08-24
申请号：EP09752988.7
申请日：2009-11-13
申请人： Theravance, Inc.
IPC分类号： C07D211/22 , A61K31/4409 , A61P25/00
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
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2.发明公开1 - (2 - PHENOXYMETHYLPHENYL) PIPERAZINE COMPOUNDS AS SEROTONIN AND NOREPINEPHRINE REUPTAKE INHIBITORS 审中-公开1-（2- PHENOXYMETHYLPHENYL-）哌嗪ALS羟色胺和去甲肾上腺素再摄取抑制剂
公开(公告)号：EP2523945A1
公开(公告)日：2012-11-21
申请号：EP11700711.2
申请日：2011-01-10
申请人： Theravance, Inc.
IPC分类号： C07D295/096 , C07D295/205 , A61K31/495 , A61P25/00 , A61P25/24
CPC分类号： C07D295/096 , A61K31/495 , C07D295/155 , C07D295/205
摘要： The invention relates to compounds of formula (I): where a, and R
1 through R
6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.-
公开(公告)号：EP2358675B9
公开(公告)日：2019-09-11
申请号：EP09752688.3
申请日：2009-11-13
申请人： Theravance, Inc.
IPC分类号： C07D211/22 , A61K31/4409 , A61P25/00
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公开(公告)号：EP2627630A1
公开(公告)日：2013-08-21
申请号：EP11773367.5
申请日：2011-10-10
申请人： Theravance, Inc.
IPC分类号： C07D207/08 , C07D401/12 , A61K31/40 , A61P11/00
CPC分类号： C07D207/08 , C07D207/12 , C07D401/12
摘要： In one aspect, the invention relates to compounds of formula I: (I) where X, Y, R
1 , R
2 , R
3 , R
4 , R
4 , and n are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.-
公开(公告)号：EP2456436B1
公开(公告)日：2014-06-25
申请号：EP10735120.7
申请日：2010-07-14
申请人： Theravance, Inc.
发明人： STANGELAND, Eric L. , SCHMIDT, Jane , SAITO, Daisuke Roland , HUGHES, Adam , PATTERSON, Lori Jean
IPC分类号： A61K31/40 , A61P29/00 , C07D207/08 , C07D405/06 , A61K31/4025
CPC分类号： A61K31/40 , A61K31/4025 , C07D207/08 , C07D405/06
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6.发明授权Crystalline form of a 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compound 有权4- [2-（2-氟苯氧基甲基）苯基]哌啶的Ktistalline形式
公开(公告)号：EP2358676B1
公开(公告)日：2012-10-10
申请号：EP09752988.7
申请日：2009-11-13
申请人： Theravance, Inc.
IPC分类号： C07D211/22 , A61K31/4409 , A61P25/00
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
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公开(公告)号：EP2456436A1
公开(公告)日：2012-05-30
申请号：EP10735120.7
申请日：2010-07-14
申请人： Theravance, Inc.
发明人： STANGELAND, Eric L. , SCHMIDT, Jane , SAITO, Daisuke Roland , HUGHES, Adam , PATTERSON, Lori Jean
CPC分类号： A61K31/40 , A61K31/4025 , C07D207/08 , C07D405/06
摘要： In one aspect, the invention relates to compounds of formula (I) where R
1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.摘要翻译： 一方面，本发明涉及其中R 1-6如说明书中所定义的式（I）的化合物或其药学上可接受的盐。 式I化合物是血清素和去甲肾上腺素再摄取抑制剂。 另一方面，本发明涉及包含此类化合物的药物组合物; 使用这些化合物的方法; 以及用于制备这些化合物的方法和中间体。
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8.发明公开1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS 有权1-（2-苯甲基乙基）哌嗪在PIPERAZINVERBINDUNGEN
公开(公告)号：EP2550252A1
公开(公告)日：2013-01-30
申请号：EP11714878.3
申请日：2011-03-21
申请人： Theravance, Inc.
IPC分类号： C07D213/30 , C07D213/61 , C07D213/74 , C07D307/42 , C07D307/56 , C07D333/16 , A61K31/4427 , A61K31/341 , A61K31/381 , A61P29/00
CPC分类号： C07D401/04 , C07D213/30 , C07D213/61 , C07D213/74 , C07D307/42 , C07D307/56 , C07D333/16 , C07D405/04 , C07D409/04
摘要： The invention relates to compounds of formula I: (I) where X, HAr, a, and R
1 through R
6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.-
公开(公告)号：EP2358675B1
公开(公告)日：2012-10-03
申请号：EP09752688.3
申请日：2009-11-13
申请人： Theravance, Inc.
IPC分类号： C07D211/22 , A61K31/4409 , A61P25/00
CPC分类号： A61K31/4465 , C07D211/22 , C07D211/32
摘要： The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
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公开(公告)号：EP2454234A2
公开(公告)日：2012-05-23
申请号：EP10732609.2
申请日：2010-07-12
申请人： Theravance, Inc.
发明人： STANGELAND, Eric L. , SAITO, Daisuke Roland , HUGHES, Adam , SCHMIDT, Jane , VAN DYKE, Priscilla , PATTERSON, Lori Jean
IPC分类号： C07D207/08 , A61P25/00 , A61K31/40 , A61P29/00
CPC分类号： C07D207/08 , A61K31/40 , A61K45/06
摘要： In one aspect, the invention relates to compounds of formula I: where R1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 一方面，本发明涉及式（I）的化合物：其中R 1-6如说明书中所定义，或其药学上可接受的盐。 式（I）化合物是血清素和去甲肾上腺素再摄取抑制剂。 另一方面，本发明涉及包含此类化合物的药物组合物; 使用这些化合物的方法; 以及用于制备这些化合物的方法和中间体。
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