公开(公告)号：EP1866284A1

公开(公告)日：2007-12-19

申请号：EP06737789.5

申请日：2006-03-09

申请人： Theravance, Inc.

发明人： MU, YongQui ,  JI, Yu-Hua ,  MAMMEN, Mathai ,  STANGELAND, Eric L.

IPC分类号： C07D211/46 ,  C07D405/12 ,  A61K31/445 ,  A61K31/4525

CPC分类号： C07D211/46 ,  C07D405/12

摘要： The invention provides compounds of formula (I): wherein a, b, c, p, W, A, X1, R1, R2, R3, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：EP2635571A1

公开(公告)日：2013-09-11

申请号：EP11784875.4

申请日：2011-11-03

申请人： Theravance, Inc.

发明人： MCKINNELL, Robert Murray ,  LONG, Daniel D. ,  VAN ORDEN, Lori Jean ,  JIANG, Lan ,  LOO, Mandy ,  SAITO, Daisuke Roland ,  ZIPFEL, Sheila ,  STANGELAND, Eric L. ,  LEPACK, Kassandra ,  OGAWA, Gavin ,  HUANG, Xiaojun ,  ZHANG, Weijiang

IPC分类号： C07D403/14 ,  A61K31/4025 ,  A61K31/12

CPC分类号： C07D401/14 ,  A61K31/496 ,  A61K45/06 ,  C07D403/14

摘要： The invention provides compounds of formula (I) wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of replication of the hepatitis C virus. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat hepatitis C viral infections, and processes and intermediates useful for preparing such compounds.

公开(公告)号：EP2523945A1

公开(公告)日：2012-11-21

申请号：EP11700711.2

申请日：2011-01-10

申请人： Theravance, Inc.

发明人： STANGELAND, Eric L. ,  PATTERSON, Lori Jean

IPC分类号： C07D295/096 ,  C07D295/205 ,  A61K31/495 ,  A61P25/00 ,  A61P25/24

CPC分类号： C07D295/096 ,  A61K31/495 ,  C07D295/155 ,  C07D295/205

摘要： The invention relates to compounds of formula (I): where a, and R
1 through R
6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：EP2358675B9

公开(公告)日：2019-09-11

申请号：EP09752688.3

申请日：2009-11-13

申请人： Theravance, Inc.

发明人： PATTERSON, Lori Jean ,  STANGELAND, Eric L. ,  ZIPFEL, Sheila ,  LONG, Daniel D.

IPC分类号： C07D211/22 ,  A61K31/4409 ,  A61P25/00

公开(公告)号：EP2627630A1

公开(公告)日：2013-08-21

申请号：EP11773367.5

申请日：2011-10-10

申请人： Theravance, Inc.

发明人： STANGELAND, Eric L. ,  PATTERSON, Lori Jean ,  SAITO, Daisuke Roland

IPC分类号： C07D207/08 ,  C07D401/12 ,  A61K31/40 ,  A61P11/00

CPC分类号： C07D207/08 ,  C07D207/12 ,  C07D401/12

摘要： In one aspect, the invention relates to compounds of formula I: (I) where X, Y, R
1 , R
2 , R
3 , R
4 , R
4 , and n are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

公开(公告)号：EP1893577A1

公开(公告)日：2008-03-05

申请号：EP06772935.0

申请日：2006-06-12

申请人： Theravance, Inc.

发明人： JI, Yu-Hua ,  MAMMEN, Mathai ,  HUSFELD, Craig ,  LI, Li ,  MU, YongQi ,  KUSHNER, Aaron ,  STANGELAND, Eric L. ,  MISCHKI, Trevor ,  HUGHES, Adam ,  DUNHAM, Sarah

IPC分类号： C07D211/46 ,  C07D405/12 ,  C07D401/12 ,  C07D409/12 ,  C07D487/08 ,  A61K31/445 ,  A61P11/00 ,  A61P11/08 ,  A61P11/06

CPC分类号： C07D211/46 ,  C07D405/12 ,  C07D409/12 ,  C07D487/08

摘要： The invention provides compounds of formula (I) wherein a, b, c, m, s, t, W, Z, Ar, R1, R2, R3, R6, and R7 are as defined in the specification. The compounds of formula (I) are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：EP2456436B1

公开(公告)日：2014-06-25

申请号：EP10735120.7

申请日：2010-07-14

申请人： Theravance, Inc.

发明人： STANGELAND, Eric L. ,  SCHMIDT, Jane ,  SAITO, Daisuke Roland ,  HUGHES, Adam ,  PATTERSON, Lori Jean

IPC分类号： A61K31/40 ,  A61P29/00 ,  C07D207/08 ,  C07D405/06 ,  A61K31/4025

CPC分类号： A61K31/40 ,  A61K31/4025 ,  C07D207/08 ,  C07D405/06

公开(公告)号：EP2456436A1

公开(公告)日：2012-05-30

申请号：EP10735120.7

申请日：2010-07-14

申请人： Theravance, Inc.

发明人： STANGELAND, Eric L. ,  SCHMIDT, Jane ,  SAITO, Daisuke Roland ,  HUGHES, Adam ,  PATTERSON, Lori Jean

IPC分类号： A61K31/40 ,  A61P29/00

CPC分类号： A61K31/40 ,  A61K31/4025 ,  C07D207/08 ,  C07D405/06

摘要： In one aspect, the invention relates to compounds of formula (I) where R
1-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.

摘要翻译： 一方面，本发明涉及其中R 1-6如说明书中所定义的式（I）的化合物或其药学上可接受的盐。 式I化合物是血清素和去甲肾上腺素再摄取抑制剂。 另一方面，本发明涉及包含此类化合物的药物组合物; 使用这些化合物的方法; 以及用于制备这些化合物的方法和中间体。

公开(公告)号：EP1856112A1

公开(公告)日：2007-11-21

申请号：EP06737555.0

申请日：2006-03-09

申请人： Theravance, Inc.

发明人： JI, Yu-Hua ,  HUSFELD, Craig ,  LI, Li ,  MAMMEN, Mathai ,  MU, YongQi ,  STANGELAND, Eric L.

IPC分类号： C07D409/12 ,  C07D405/14 ,  C07D401/12 ,  C07D211/62 ,  A61K31/445 ,  A61K31/4525 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  C07D401/14

CPC分类号： C07D405/14 ,  C07D211/62 ,  C07D401/12 ,  C07D409/14

摘要： The invention provides compounds of formula I: wherein a, b, c, d, n, R1, R2, R3, R6, R7, W, and A are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.

公开(公告)号：EP2550252A1

公开(公告)日：2013-01-30

申请号：EP11714878.3

申请日：2011-03-21

申请人： Theravance, Inc.

发明人： STANGELAND, Eric L. ,  PATTERSON, Lori Jean ,  ZIPFEL, Sheila

IPC分类号： C07D213/30 ,  C07D213/61 ,  C07D213/74 ,  C07D307/42 ,  C07D307/56 ,  C07D333/16 ,  A61K31/4427 ,  A61K31/341 ,  A61K31/381 ,  A61P29/00

CPC分类号： C07D401/04 ,  C07D213/30 ,  C07D213/61 ,  C07D213/74 ,  C07D307/42 ,  C07D307/56 ,  C07D333/16 ,  C07D405/04 ,  C07D409/04

摘要： The invention relates to compounds of formula I: (I) where X, HAr, a, and R
1 through R
6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are serotonin and norepinephrine reuptake inhibitors. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.