-
公开(公告)号：EP1091920A1
公开(公告)日：2001-04-18
申请号：EP99928139.7
申请日：1999-06-30
发明人： POLIAKOFF, Martyn , MEEHAN, Nicola, Jane , ROSS, Stephen, Keith , WIELAND, Stefan , ROEDER, Stefan
CPC分类号： C07C45/50 , Y02P20/544 , C07C47/02
摘要： In a process for the hydroformylation of alkanes, alkenes or trialkylboranes under supercritical or near-critical conditions, hydroformylation is effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation may be achieved by independently varying one or more of the temperature, pressure, catalyst, mole ratios of hydrogen and carbon monoxide and flow rate.
-
公开(公告)号：EP1185492B1
公开(公告)日：2005-05-25
申请号：EP00906477.5
申请日：2000-02-24
发明人： POLIAKOFF, Martyn , GRAY, William Keith , SWAN, Thomas Macklyn, Thomas Swan & Co. Ltd. , ROSS, Stephen Keith, Thomas Swan & Co. Ltd. , WIELAND, Stefan , ROEDER, Stefan
CPC分类号： C07D317/12 , C07C1/24 , C07C41/09 , C07D307/08 , Y02P20/544 , C07C11/10 , C07C43/04 , C07C43/13 , C07C43/10
摘要： The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.
-
公开(公告)号：EP1091920B1
公开(公告)日：2003-10-29
申请号：EP99928139.7
申请日：1999-06-30
发明人： POLIAKOFF, Martyn , MEEHAN, Nicola, Jane , ROSS, Stephen, Keith , WIELAND, Stefan , ROEDER, Stefan
CPC分类号： C07C45/50 , Y02P20/544 , C07C47/02
摘要： In a process for the hydroformylation of alkanes, alkenes or trialkylboranes under supercritical or near-critical conditions, hydroformylation is effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation may be achieved by independently varying one or more of the temperature, pressure, catalyst, mole ratios of hydrogen and carbon monoxide and flow rate.
-
公开(公告)号：EP1185492A1
公开(公告)日：2002-03-13
申请号：EP00906477.5
申请日：2000-02-24
发明人： POLIAKOFF, Martyn , GRAY, William Keith , SWAN, Thomas Macklyn,Thomas Swan & Co. Ltd. , ROSS, Stephen Keith,Thomas Swan & Co. Ltd. , WIELAND, Stefan , ROEDER, Stefan
CPC分类号： C07D317/12 , C07C1/24 , C07C41/09 , C07D307/08 , Y02P20/544 , C07C11/10 , C07C43/04 , C07C43/13 , C07C43/10
摘要： The present invention relates to methods for inhibiting cathepsin K activity in a mammal in need thereof comprising administering a nitric oxide donor compound having cathepsin K inhibition activity. The present invention also relates to methods for inhibiting bone resorption in a mammal comprising administering to a mammal in need thereof a therapeutically effective amount of such a nitric oxide donor. The present invention also relates to compositions comprising such a nitric oxide donor.
-
公开(公告)号：EP0929501B1
公开(公告)日：2003-07-30
申请号：EP97943078.2
申请日：1997-09-29
发明人： SWAN, Thomas Macklyn, Thomas Swan & Co. Ltd. , ROSS, Stephen Keith, Thomas Swan & Co. Ltd. , POLIAKOFF, Martyn , HITZLER, Martin, Georg , SMAIL, Fiona, Ruth , TACKE, Thomas , WIELAND, Stefan
CPC分类号： C07C45/46 , B01J3/008 , C07B37/02 , C07B37/04 , C07C2/66 , C07C2/864 , C07C41/30 , C07C2521/16 , C07C2529/04 , C07C2531/02 , C07C2531/08 , Y02P20/544 , C07C15/02 , C07C43/205
摘要： Method of performing alkylation or acylation reactions of aromatic substrates under supercritical or near-critical reaction conditions. In particular, a method of performing Friedel-Crafts alkylation or acylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of the temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to acylating or alkylating agent.
-
公开(公告)号：EP0906253B1
公开(公告)日：2003-05-14
申请号：EP97916550.3
申请日：1997-04-11
发明人： POLIAKOFF, Martyn , SWAN, Thomas, M. , TACKE, Thomas , HITZLER, Martin, G. , ROSS, Stephen, K. , WIELAND, Stefan
CPC分类号： C07C29/145 , B01J3/008 , C07B35/02 , C07B43/04 , C07C29/132 , C07C29/141 , C07C29/20 , C07C45/58 , C07C209/36 , C07C2601/14 , C07D317/66 , Y02P20/544 , C07C31/10 , C07C35/08 , C07C33/22 , C07C31/1355
摘要： A process for the selective hydrogenation of aliphatic or aromatic substrates under supercritical or near critical conditions. Hydrogenation is effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near critical reaction medium and selectively product formation is achieved by varying one or more of the temperature, pressure, catalyst and flow rate.
摘要翻译： PCT No.PCT / GB97 / 01014 Sec。 371日期1999年2月18日 102（e）1999年2月18日PCT PCT 1997年4月11日PCT公布。 出版物WO97 / 38955 日期1997年10月23日在超临界或近临界条件下选择性氢化醛类或芳族底物的方法。 在包含超临界或近临界反应介质的连续流动反应器中使用非均相催化剂进行氢化，并通过改变一种或多种温度，压力，催化剂和流速来实现选择性产物形成。
-
公开(公告)号：EP0929501A1
公开(公告)日：1999-07-21
申请号：EP97943078.0
申请日：1997-09-29
发明人： SWAN, Thomas Macklyn, Thomas Swan & Co. Ltd. , ROSS, Stephen Keith, Thomas Swan & Co. Ltd. , POLIAKOFF, Martyn , HITZLER, Martin, Georg , SMAIL, Fiona, Ruth , TACKE, Thomas , WIELAND, Stefan
CPC分类号： C07C45/46 , B01J3/008 , C07B37/02 , C07B37/04 , C07C2/66 , C07C2/864 , C07C41/30 , C07C2521/16 , C07C2529/04 , C07C2531/02 , C07C2531/08 , Y02P20/544 , C07C15/02 , C07C43/205
摘要： Method of performing alkylation or acylation reactions of aromatic substrates under supercritical or near-critical reaction conditions. In particular, a method of performing Friedel-Crafts alkylation or acylation reactions is disclosed under those conditions. Friedel-Crafts reactions may be effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near-critical reaction medium. Selectivity of product formation can be achieved by varying one or more of the temperature, pressure, catalyst, flow rates and also by varying the ratios of aromatic substrate to acylating or alkylating agent.
摘要翻译： 在超临界或近临界反应条件下进行芳香族底物的烷基化或酰化反应的方法。 具体而言，在这些条件下公开了进行Friedel-Crafts烷基化或酰化反应的方法。 弗瑞德 - 克来福特反应可以使用非均相催化剂在含有超临界或近临界反应介质的连续流动反应器中进行。 产物形成的选择性可以通过改变温度，压力，催化剂，流速中的一种或多种以及通过改变芳族底物与酰化剂或烷化剂的比率来实现。
-
公开(公告)号：EP0906253A1
公开(公告)日：1999-04-07
申请号：EP97916550.0
申请日：1997-04-11
发明人： POLIAKOFF, Martyn , SWAN, Thomas, M. , TACKE, Thomas , HITZLER, Martin, G. , ROSS, Stephen, K. , WIELAND, Stefan
CPC分类号： C07C29/145 , B01J3/008 , C07B35/02 , C07B43/04 , C07C29/132 , C07C29/141 , C07C29/20 , C07C45/58 , C07C209/36 , C07C2601/14 , C07D317/66 , Y02P20/544 , C07C31/10 , C07C35/08 , C07C33/22 , C07C31/1355
摘要： A process for the selective hydrogenation of aliphatic or aromatic substrates under supercritical or near critical conditions. Hydrogenation is effected using a heterogeneous catalyst in a continuous flow reactor containing a supercritical or near critical reaction medium and selectively product formation is achieved by varying one or more of the temperature, pressure, catalyst and flow rate.
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.014 秒)
