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公开(公告)号：EP2705855B1
公开(公告)日：2018-06-13
申请号：EP12781667.6
申请日：2012-04-27
IPC分类号： A61K41/00 , A61K31/197 , A61K33/24 , A61K49/00 , A61P35/00 , A61K31/409
CPC分类号： A61K31/409 , A61K31/197 , A61K41/0061 , A61K41/0071 , A61K49/0019 , A61K49/0021 , A61K49/0052 , A61K49/0093
摘要： It is intended to provide a therapeutic and/or diagnostic agent that can be used in photodynamic therapy (PDT) or photodynamic diagnosis (PDD) capable of utilizing infrared-spectrum light such as near-infrared light (NIR), infrared light, or far-infrared light, which attains a deep body penetration. The present invention provides a photodynamic therapeutic or diagnostic agent or a photodynamic therapeutic or diagnostic kit for cancer or infectious disease, comprising: a particle (e.g., a lanthanide particle) that emits upconversion luminescence by infrared-spectrum light such as near-infrared light having a wavelength of 0.7 µm to 2.5 µm; and a photosensitizer (e.g., porphyrin) or a 5-aminolevulinic acid group.
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公开(公告)号：EP2705855A1
公开(公告)日：2014-03-12
申请号：EP12781667.6
申请日：2012-04-27
CPC分类号： A61K31/409 , A61K31/197 , A61K41/0061 , A61K41/0071 , A61K49/0019 , A61K49/0021 , A61K49/0052 , A61K49/0093
摘要： It is intended to provide a therapeutic and/or diagnostic agent that can be used in photodynamic therapy (PDT) or photodynamic diagnosis (PDD) capable of utilizing infrared-spectrum light such as near-infrared light (NIR), infrared light, or far-infrared light, which attains a deep body penetration. The present invention provides a photodynamic therapeutic or diagnostic agent or a photodynamic therapeutic or diagnostic kit for cancer or infectious disease, comprising: a particle (e.g., a lanthanide particle) that emits upconversion luminescence by infrared-spectrum light such as near-infrared light having a wavelength of 0.7 µm to 2.5 µm; and a photosensitizer (e.g., porphyrin) or a 5-aminolevulinic acid group.
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3.发明公开DEVICE FOR DETERMINING METASTASIS OF CANCER TO SENTINEL LYMPH NODE 审中-公开VORRICHTUNG ZUR BESTIMMUNG DER METASTASE VON KREBS AUFWÄCHTERLYMPHKNOTEN
公开(公告)号：EP2835094A1
公开(公告)日：2015-02-11
申请号：EP13773042.0
申请日：2013-03-27
CPC分类号： A61B5/418 , A61B1/00165 , A61B1/043 , A61B5/0071 , A61B5/0084 , A61B10/0041 , F04C2270/041 , G01N2021/6484
摘要： Provided is a device capable of determining whether or not cancer has metastasized to a sentinel lymph node, such as the axillary lymph node, thickly covered with fat, safely and in a simple manner without confirmation by biopsy or extirpation. Fluorescence generated in a sentinel lymph node upon the excitation of protoporphyrin (a photosensitizing substance) derived from 5-ALA administered to a subject can be detected by passing a hollow tube, into which a small-diameter optical fiber for launching light and the small-diameter optical fiber for receiving light are inserted, through the lymph vessel to identify the presence or absence of the metastasis of cancer cells even before the surgery of cancer or during prognosis.
摘要翻译： 提供了一种能够确定癌症是否已经转移到前哨淋巴结（例如腋窝淋巴结）的装置，所述前哨淋巴结（例如腋窝淋巴结）被安全地并且以简单的方式以脂肪覆盖，而没有通过活组织检查或抽搐确认。 通过给予受试者的5-ALA衍生的原卟啉（光敏物质）的激发后的前哨淋巴结中产生的荧光可以通过中空管来检测，中空管用于发射小光纤的小直径光纤， 通过淋巴管插入用于接收光的直径光纤，以便即使在癌症手术或预后之前也可以确定癌细胞转移的存在或不存在。
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公开(公告)号：EP2888988A1
公开(公告)日：2015-07-01
申请号：EP13831452.1
申请日：2013-08-21
CPC分类号： A61B5/0071 , A61B1/00096 , A61B1/00167 , A61B1/043 , A61B1/0607 , A61B1/063 , A61B1/07 , A61B5/0084 , A61B5/7282 , A61B5/7405 , A61B2562/0238 , G01N21/645 , G01N2021/6484 , G02B21/0012 , G02B23/2469 , G02B23/26
摘要： An object of the present invention is to provide a PDD diagnosis apparatus that even if there is a distance from an irradiation portion of an optical fiber to a diseased tissue, enables provision of a fluorescence detection sensitivity equivalent to that in a case where irradiation is provided in such a manner that the irradiation portion of the optical fiber is brought close to the diseased tissue. A diagnosis apparatus including: a light source unit that emits excitation light to a photosensitizing substance accumulated in a diseased tissue; a detection unit that detects fluorescence produced from the photosensitizing substance; and an excitation light irradiation/fluorescence detection optical fiber including an output/input end with a collimator connected thereto, in which the excitation light emitted from the light source unit is guided to the excitation light irradiation/fluorescence detection optical fiber, and the excitation light output from the output/input end is provided in such a manner that the excitation light is collimated by the collimator and excites the photosensitizing substance accumulated in the diseased tissue; and the fluorescence produced by the photosensitizing substance excited by the excitation light is input from the output/input end via the collimator, and the input fluorescence is guided to the excitation light irradiation/fluorescence detection optical fiber and the fluorescence produced from the photosensitizing substance is detected in the detection unit is used.
摘要翻译： 本发明的目的是提供一种PDD诊断装置，即使距离光纤的照射部分到患病组织有距离，能够提供与提供照射的情况相同的荧光检测灵敏度 使得光纤的照射部分靠近病变组织。 一种诊断装置，包括：光源单元，其向累积在患病组织中的光敏物质发射激发光; 检测单元，其检测由所述光敏物质产生的荧光; 以及激励光照射/荧光检测光纤，其包括具有连接到其上的准直器的输出端，其中从光源单元发射的激发光被引导到激发光照射/荧光检测光纤，并且激发光 以使得激发光被准直仪准直并激发累积在病变组织中的光敏物质的方式提供从输出/输入端输出; 并且通过准直器从输出输入端输入由激发光激发的光敏物质产生的荧光，并将输入荧光引导至激发光照射/荧光检测光纤，由光敏物质产生的荧光为 使用在检测单元中检测到的。
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公开(公告)号：EP2722041B1
公开(公告)日：2018-10-24
申请号：EP12801049.3
申请日：2012-06-15
发明人： TANAKA, Tohru , INOUE, Katsushi , TAKAHASHI, Kiwamu , ISHII, Takuya , NUMATA, Tsutomu , SHIBUYA, Mariko , SUZUKI, Takeshi
CPC分类号： A61N5/062 , A61K9/0043 , A61K9/06 , A61K41/0061 , F04C2270/0421
摘要： Provided is a therapeutic agent capable of treating allergic rhinitis in a safe, simple, and noninvasive manner substantially without side effects and physical distress to patients. Provided is a therapeutic agent for allergic rhinitis for 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) comprising 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of the 5-aminolevulinic acid or the derivative as an active ingredient, and used in ALA-PDT in which light having a wavelength of 400 nm to 700 nm is irradiated; and particularly provided is a therapeutic agent for allergic rhinitis in a locally applied solution form, a water-soluble ointment-dissolved form, a jelly-dissolved form, or the like. The therapeutic agent does not require the conduct of 5-aminolevulinic acid-based photodynamic diagnosis (ALA-PDD) for detecting a site of protoporphyrin IX (PpIX) accumulation radiating light having a wavelength of 610 nm to 650 nm under irradiation of excitation light having a wavelength of 380 nm to 420 nm before ALA-PDT.
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6.发明公开PHOTODYNAMIC THERAPY USING PHOTOSENSITIZING AGENT OR 5-AMINOLEVULINIC ACID 审中-公开荧光素酶治疗麻醉剂EINEM FOTOSENBILATOR ODER 5-AMINOLÄVULINSÄURE
公开(公告)号：EP2727603A1
公开(公告)日：2014-05-07
申请号：EP12807976.1
申请日：2012-06-20
发明人： TANAKA, Tohru , INOUE, Katsushi , ISHII, Takuya , YOSHIDA, Takato
IPC分类号： A61K41/00 , A61K31/197 , A61N5/067 , A61P35/00
CPC分类号： A61N5/062 , A61K31/197 , A61K41/0061 , A61K41/0071 , A61K49/0052
摘要： It is to provide photodynamic therapy (PDT) and photodynamic diagnosis (PDD) which are suitable for the diagnosis and therapy of a part requiring a certain degree of deep penetration, such as subcutaneous cancer and lymph nodes surrounded by blood vessels and fat. This is solved by performing PDT and PDD targeting cancer by administering a composition comprising a photosensitizing agent such as a tetrapyrrole-based compound (photofrin, protoporphyrin IX, etc.) or ALAs such as 5-aminolevulinic acid (ALA), ALA methyl ester, ALA ethyl ester, ALA propyl ester, ALA butyl ester, ALA pentyl ester, or a hydrochloride, phosphate, or sulfate thereof followed by irradiation with excitation light at a wavelength of 480 to 580 nm.
摘要翻译： 提供光动力治疗（PDT）和光动力诊断（PDD），适用于需要一定程度深度穿透的部位的诊断和治疗，如皮下癌和由血管和脂肪包围的淋巴结。 这可以通过施用包含光敏剂如四吡咯基化合物（光调节素，原卟啉IX等）或ALA的组合物，例如5-氨基乙酰丙酸（ALA），ALA甲酯， ALA乙酯，ALA丙酯，ALA丁酯，ALA戊酯或其盐酸盐，磷酸盐或硫酸盐，随后用波长480〜580nm的激发光照射。
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公开(公告)号：EP2722041A1
公开(公告)日：2014-04-23
申请号：EP12801049.3
申请日：2012-06-15
发明人： TANAKA, Tohru , INOUE, Katsushi , TAKAHASHI, Kiwamu , ISHII, Takuya , NUMATA, Tsutomu , SHIBUYA, Mariko , SUZUKI, Takeshi
CPC分类号： A61N5/062 , A61K9/0043 , A61K9/06 , A61K41/0061 , F04C2270/0421
摘要： Provided is a therapeutic agent capable of treating allergic rhinitis in a safe, simple, and noninvasive manner substantially without side effects and physical distress to patients. Provided is a therapeutic agent for allergic rhinitis for 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) comprising 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of the 5-aminolevulinic acid or the derivative as an active ingredient, and used in ALA-PDT in which light having a wavelength of 400 nm to 700 nm is irradiated; and particularly provided is a therapeutic agent for allergic rhinitis in a locally applied solution form, a water-soluble ointment-dissolved form, a jelly-dissolved form, or the like. The therapeutic agent does not require the conduct of 5-aminolevulinic acid-based photodynamic diagnosis (ALA-PDD) for detecting a site of protoporphyrin IX (PpIX) accumulation radiating light having a wavelength of 610 nm to 650 nm under irradiation of excitation light having a wavelength of 380 nm to 420 nm before ALA-PDT.
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8.发明公开EXCITATION, DETECTION, AND PROJECTION SYSTEM FOR VISUALIZING TARGET CANCER TISSUE 审中-公开激发，检测和投影系统可视化有针对性的癌组织
公开(公告)号：EP2515761A1
公开(公告)日：2012-10-31
申请号：EP10842672.7
申请日：2010-12-20
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0064 , A61B5/0071 , A61B5/0077 , A61B2018/00904 , A61N5/062 , A61N2005/0626
摘要： A system visually distinguishes diseased tissue from healthy tissue after a treatment is administered to a patient to provide different concentrations of a fluorescent marking substance between the diseased tissue and the healthy tissue. A light source illuminates the tissue with excitation light. A detector detects light returning from the tissue, and a controller characterizes the returning light according to a measured property indicative of the different concentrations. A light projector projects light having a predetermined cue in response to the characterization of the returning light.
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