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    ANTIMALARIAL DRUG COMPRISING ALAREMYCIN OR DERIVATIVE THEREOF AS ACTIVE INGREDIENT
    3.
    发明公开
    ANTIMALARIAL DRUG COMPRISING ALAREMYCIN OR DERIVATIVE THEREOF AS ACTIVE INGREDIENT 有权
    抗真菌药物 - 阿兹美尼亚麻醉品麻醉科精神病药物EINEM DERIVAT DARAUS ALS WIRKSTOFF

    公开(公告)号：EP2638902A1

    公开(公告)日：2013-09-18

    申请号：EP11840434.2

    申请日：2011-11-09

    申请人： Tokyo Institute of Technology ,  SBI Pharmaceuticals Co., Ltd.

    发明人： WACHI, Masaaki ,  SATO, Shigeharu ,  TANAKA, Tohru ,  TAKAHASHI, Kiwamu

    IPC分类号： A61K31/16 ,  A61K31/197 ,  A61K31/221 ,  A61P33/06

    CPC分类号： A61K31/197 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/2018 ,  A61K9/2027 ,  A61K31/16 ,  A61K31/221 ,  Y02A50/411

    摘要： Provided is a preventive and/or therapeutic agent for malaria, comprising, as an active ingredient, 5-acetamido-4-oxo-5-hexenoic acid (Alaremycin) or a derivative thereof. A preventive and/or therapeutic agent for malaria is used which comprises, as an active ingredient, Alaremycin or a derivative thereof represented by formula (I) (wherein R 1 represents a hydroxy group, an amino group, or a substituted or unsubstituted straight chain or branched alkoxy group or alkylamino group having 1 to 8 carbons; R 2 represents hydrogen, a substituted or unsubstituted straight chain or branched alkyl group having 1 to 8 carbons, or a substituted or unsubstituted aromatic group having 4 to 10 carbons; and R 3 represents hydrogen or a methyl group).

    摘要翻译： 本发明提供疟疾的预防和/或治疗剂，其包含作为活性成分的5-乙酰氨基-4-氧代-5-己烯酸（阿拉霉霉素）或其衍生物。 使用疟疾的预防和/或治疗剂，其包含作为活性成分的由式（I）表示的阿拉霉霉素或其衍生物（其中R 1表示羟基，氨基或取代或未取代的直链 或支链烷氧基或碳原子数为1〜8的烷基氨基; R 2表示氢，取代或未取代的碳原子数1〜8的直链或支链烷基，或取代或未取代的碳原子数4〜10的芳基，R 3 表示氢或甲基）。

    CANCER HEAT THERAPY-ENHANCING AGENT
    7.
    发明公开
    CANCER HEAT THERAPY-ENHANCING AGENT 有权
    MITTEL ZURVERSTÄRKUNGEINERKREBSWÄRMETHERAPIE

    公开(公告)号：EP2617416A1

    公开(公告)日：2013-07-24

    申请号：EP11824763.4

    申请日：2011-09-12

    申请人： Tokyo University of Agriculture Educational Corporation ,  SBI Pharmaceuticals Co., Ltd.

    发明人： CHIBAZAKURA, Taku ,  TANAKA, Tohru ,  TAKAHASHI, Kiwamu ,  NAKAJIMA, Motowo ,  ABE, Fuminori

    IPC分类号： A61K31/197 ,  A61P35/00 ,  A61P43/00

    CPC分类号： C07C229/22 ,  A61K31/197

    摘要： Provided is an enhancer for cancer thermotherapy not combined with photodynamic therapy. Cancer treatment not combined with photodynamic therapy is made available by using, as an enhancer for cancer thermotherapy, 5-aminolevulinic acids represented by formula (1):

            R 2 R 1 NCH 2 COCH 2 CH 2 COR 3      (1)

    [wherein R 1 and R 2 each independently represent a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; and R 3 represents a hydroxy group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group] or a salt thereof.

    摘要翻译： 提供了不与光动力疗法结合的癌症热疗的增强剂。 通过使用作为癌症热疗的增强剂，通过式（1）表示的5-氨基乙酰丙酸可以获得不与光动力疗法组合的癌症治疗：€ƒ€ƒ€ƒ€ƒ€ƒ€ƒR2 R 1 NCH 2 COCH 2 CH 2 COR 3€ƒ€ƒ€ƒ（1）[其中R 1和R 2各自独立地表示氢原子，烷基，酰基，烷氧基羰基，芳基 ，或芳烷基; R 3表示羟基，烷氧基，酰氧基，烷氧基羰氧基，芳氧基，芳烷氧基或氨基]或其盐。

    METHOD FOR ELIMINATING STEM CELLS, METHOD FOR PROTECTING DIFFERENTIATED CELLS, AND CULTURE MEDIUM COMPOSITION
    10.
    发明公开
    METHOD FOR ELIMINATING STEM CELLS, METHOD FOR PROTECTING DIFFERENTIATED CELLS, AND CULTURE MEDIUM COMPOSITION 审中-公开
    消除干细胞的方法，保护分化细胞的方法以及培养基培养基组合物

    公开(公告)号：EP3282011A1

    公开(公告)日：2018-02-14

    申请号：EP16776540.3

    申请日：2016-04-06

    申请人： Reprocell Incorporated ,  SBI Pharmaceuticals Co., Ltd.

    发明人： YOSHIDA, Shunsuke ,  INAMURA, Mitsuru ,  TANAKA, Tohru ,  ISHIKAWA, Hiroyuki ,  ITO, Hidenori

    IPC分类号： C12N5/10 ,  C12N1/00 ,  C12N1/02 ,  C12N5/0735

    CPC分类号： C12N5/16 ,  C07C233/56 ,  C12N1/00 ,  C12N1/02 ,  C12N5/10 ,  C12N2500/32 ,  C12N2529/10

    摘要： A stem cell removing method that certainly-removes an undifferentiated stem cell is provided. For this object, a cell group including a stem cell and a somatic cell performed differentiation induction is cultivated in culture medium composition including photosensitizer. Light of a specific wavelength is irradiated with the cell group, and the stem cell is removed, selectively. The stem cell is a pluripotent stem cell or a somatic stem cell. The pluripotent stem cell includes either an ES cell (Embryonic Stem Cell) or an iPS cell (induced Pluripotent Stem Cell). Also, somatic stem cell includes any one of a germ stem cell, a productive cell, a pluripotent stem cell and a stem cell having unipotency.

    摘要翻译： 提供确实除去未分化干细胞的干细胞除去方法。 为了该目的，在包含光敏剂的培养基组合物中培养包含干细胞和体细胞的细胞组进行分化诱导。 用细胞组照射特定波长的光，并选择性地去除干细胞。 干细胞是多能干细胞或成体干细胞。 多能干细胞包括ES细胞（胚胎干细胞）或iPS细胞（诱导多能干细胞）。 此外，体干细胞包括生殖干细胞，生产细胞，多能干细胞和具有单能性的干细胞中的任一种。