公开(公告)号：EP2142660A4

公开(公告)日：2012-05-30

申请号：EP07872469

申请日：2007-12-13

申请人： UNIV ALBERTA

发明人： FELDMAN MARIO ,  FARIDMOAYER AMIRREZA

IPC分类号： C12P21/02 ,  A61K38/16 ,  A61K39/02 ,  A61K39/095 ,  A61P31/04 ,  A61P37/04 ,  C07K9/00 ,  C12N15/00 ,  C12N15/63

CPC分类号： C12P21/005 ,  C07K14/22

公开(公告)号：EP2841559A4

公开(公告)日：2015-12-16

申请号：EP13782478

申请日：2013-04-26

申请人： UNIV ALBERTA

发明人： FELDMAN MARIO ,  PRICE NANCY ,  GARCIA-QUINTANILLA FATIMA ,  IELMINI MARIA VERONICA

IPC分类号： C12N1/21 ,  A61K39/00 ,  A61K39/02 ,  A61K39/09 ,  A61K39/116 ,  A61P31/04 ,  A61P37/04 ,  C12N15/52 ,  C12N15/63 ,  C12N15/70 ,  C12P19/00 ,  C12P19/04 ,  C12P21/00

CPC分类号： A61K39/092 ,  A61K39/0208 ,  A61K2039/55555 ,  A61K2039/6018 ,  C12N15/52 ,  C12N15/70 ,  C12P19/04

公开(公告)号：EP2742355A4

公开(公告)日：2014-12-31

申请号：EP12824498

申请日：2012-08-13

申请人： UNIV ALBERTA ,  INST DE INVESTIGACIONES BIOTECNOLOGICAS INST TECNOLOGICO DE CHASCOMUS CONSEJO DE INVESTIGACIONES CIE

发明人： FELDMAN MARIO ,  IWASHKIW JEREMY ,  UGALDE JUAN ESTEBAN ,  CIOCCHINI ANDRÉS EDUARDO ,  COMERCI DIEGO JOSÉ

IPC分类号： G01N33/564

CPC分类号： G01N33/56916 ,  C07K14/205 ,  G01N33/56911 ,  G01N2333/23 ,  G01N2333/245 ,  G01N2400/00

摘要： The present application provides a method of diagnosing bacterial infections using engineered glycoproteins in an immunoassay. The engineered bacterial glycoproteins used in the immunoassay comprise a bacterial antigen covalently attached to a protein via polysaccharyltransferase (PTase)-mediated glycosylation, wherein the bacterial antigen is selected based on the bacterial infection of interest. Antibodies in a bodily fluid of subjects infected with a bacteria will bind to the engineered glycoprotein, and the resulting binding complexes are detected or quantitated.