公开(公告)号：EP2750754A4

公开(公告)日：2015-06-03

申请号：EP12842020

申请日：2012-08-31

申请人： UNIV CALIFORNIA ,  UNIV NORTH CAROLINA STATE ,  SANDIA CORP

发明人： NARAYAN ROGER ,  POLSKY RONEN ,  WANG JOSEPH ,  WINDMILLER JOSHUA RAY ,  MILLER PHILIIIP ,  EDWARDS THAYNE L

IPC分类号： A61M37/00 ,  A61B5/00 ,  A61B5/145 ,  A61M5/158 ,  G01N33/48 ,  G01N33/50

CPC分类号： A61B5/1473 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/150984 ,  A61B5/157 ,  A61B5/4845 ,  A61B5/6833 ,  A61B5/685 ,  A61B5/7282 ,  A61B10/0045 ,  A61B2010/008 ,  A61B2562/028 ,  A61B2562/046 ,  A61M5/158 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2037/0023 ,  A61M2037/003 ,  G01N33/48785

摘要： Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a^ device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.

公开(公告)号：EP2858554A4

公开(公告)日：2016-02-24

申请号：EP13804280

申请日：2013-06-11

申请人： UNIV CALIFORNIA

发明人： MATTREY ROBERT ,  WU ZHE ,  OLSON EMILIA ,  WANG JOSEPH ,  GAO WEI ,  MALONE CHRISTOPHER

IPC分类号： A61B5/0215 ,  A61B5/0245 ,  A61B5/04 ,  A61B5/042 ,  A61B8/00 ,  A61K49/22

CPC分类号： A61B8/481 ,  A61B8/0841 ,  A61B8/4483 ,  A61B90/39 ,  A61B2090/3925 ,  A61F2/0063 ,  A61F2/02 ,  A61F2250/0096 ,  A61K49/223 ,  A61K49/225 ,  A61M25/0108

摘要： A method and system are provided for detection of localized hydrogen peroxide within tissue by introducing a catalase-containing material into at location of interest, positioning an ultrasound transducer over the location, and generating an ultrasound image to detect microbubbles, where the presence of microbubbles indicate the presence of localized hydrogen peroxide. The catalase-coated surface may be the inner surface of a microtube, on the surface of or incorporated within a nanosphere or microsphere, or an implantable device.

摘要翻译： 提供了一种方法和系统，用于通过将含有过氧化氢酶的材料引入感兴趣的位置来检测组织内的局部过氧化氢，将超声换能器定位在该位置上，并产生超声图像以检测微泡，其中微泡的存在指示 局部过氧化氢的存在。 过氧化氢酶涂覆的表面可以是微管的内表面，在纳米球或微球的表面或纳入纳米球或微球体的内表面，或可植入装置。

公开(公告)号：EP3069401A4

公开(公告)日：2017-03-29

申请号：EP14861242

申请日：2014-11-17

申请人： UNIV CALIFORNIA

发明人： RUSTOMJI CYRUS ,  JIN SUNGHO ,  KIM TAEKYOUNG ,  YOU JUNGMIN ,  WANG JOSEPH ,  CHOI DUYOUNG

IPC分类号： H01M10/0569 ,  C25D3/42 ,  C25D3/44 ,  C25D3/50 ,  C25D3/54 ,  C25D5/00 ,  C25D9/08 ,  C25D17/02 ,  C25D21/00 ,  H01G11/60 ,  H01G11/62 ,  H01M4/38 ,  H01M10/052 ,  H01M10/0564

CPC分类号： H01M10/0569 ,  C25D3/42 ,  C25D3/44 ,  C25D3/50 ,  C25D3/54 ,  C25D5/003 ,  C25D9/08 ,  C25D17/02 ,  C25D21/00 ,  H01G11/22 ,  H01G11/46 ,  H01G11/60 ,  H01G11/62 ,  H01G11/78 ,  H01G11/86 ,  H01M4/382 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0564 ,  H01M2300/0028 ,  H01M2300/0031 ,  H01M2300/0034 ,  Y02E60/13

摘要： Disclosed are novel electrolytes, and techniques for making and devices using such electrolytes, which are based on compressed gas solvents. Unlike conventional electrolytes, disclosed electrolytes are based on “compressed gas solvents” mixed with various salts, referred to as “compressed gas electrolytes.” Various embodiments of a compressed gas solvent includes a material that is in a gas phase and has a vapor pressure above an atmospheric pressure at a room temperature. The disclosed compressed gas electrolytes can have wide electrochemical potential windows, high conductivity, low temperature capability and/or high pressure solvent properties.

摘要翻译： 本发明公开了基于压缩气体溶剂的新型电解质以及使用这种电解质的制造技术和装置。 与常规电解质不同，所公开的电解质基于与各种盐混合的“压缩气体溶剂”，称为“压缩气体电解质”。压缩气体溶剂的各种实施方案包括处于气相并且具有高于 在室温下的大气压。 所公开的压缩气体电解质可以具有宽的电化学电位窗口，高导电性，低温能力和/或高压溶剂性质。

公开(公告)号：EP3097411A4

公开(公告)日：2017-08-16

申请号：EP15740704

申请日：2015-01-21

申请人： UNIV CALIFORNIA

发明人： WANG JOSEPH ,  MERCIER PATRICK

IPC分类号： G01N27/327 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B10/00 ,  A61C19/04 ,  C23C28/00 ,  H01M8/16

CPC分类号： A61B5/1486 ,  A61B5/14507 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/6802 ,  A61B5/682 ,  A61B10/0051 ,  A61B2560/0214 ,  A61C19/04 ,  G01N27/3272 ,  H01M8/16 ,  Y02E60/527

摘要： Methods, systems, and devices are disclosed mouth-based biosensors and biofuel cells. In one aspect, an electrochemical sensor device for detecting analytes in saliva includes a substrate including an electrically insulative material, a first electrode disposed on the substrate at a first location, in which the first electrode includes a surface including a chemical agent (e.g., a catalyst or a reactant) corresponding to an analyte in saliva; and a second electrode disposed on the substrate at a second location separated from the first electrode by a spacing region, the first and second electrodes capable of sustaining a redox reaction involving the chemical agent and the analyte to produce an electrical signal, such that, when the device is present in the mouth of a user and electrically coupled to an electrical circuit, the device is operable to detect the analyte in the user's saliva.

摘要翻译： 公开的方法，系统和装置是基于口的生物传感器和生物燃料电池。 在一个方面，用于检测唾液中的分析物的电化学传感器装置包括：包含电绝缘材料的衬底;第一电极，其布置在衬底上的第一位置处，其中第一电极包括包含化学试剂（例如， 催化剂或反应物）对应于唾液中的分析物; 以及第二电极，所述第二电极在与所述第一电极隔开间隔区域的第二位置处设置在所述衬底上，所述第一和第二电极能够维持涉及所述化学试剂和所述分析物的氧化还原反应以产生电信号，使得当 该设备存在于用户的嘴中并且电耦合到电路，该设备可操作以检测用户唾液中的分析物。

公开(公告)号：EP2850421A4

公开(公告)日：2016-01-20

申请号：EP13827958

申请日：2013-05-10

申请人： UNIV CALIFORNIA

发明人： WANG JOSEPH ,  WINDMILLER JOSHUA RAY ,  BANDODKAR AMAY JAIRAJ

IPC分类号： G01N27/26 ,  G01N27/327 ,  G01N27/403

CPC分类号： A61B5/6833 ,  A61B5/14517 ,  A61B5/14539 ,  A61B5/1477 ,  A61B5/1486 ,  B32B37/1284 ,  B32B38/10 ,  B32B38/145 ,  B32B2255/12 ,  B32B2307/202 ,  B32B2307/206 ,  B32B2311/02 ,  B32B2323/04 ,  B32B2367/00 ,  B32B2383/00 ,  B32B2405/00 ,  B32B2556/00 ,  Y10T156/10