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公开(公告)号：EP0690712A4
公开(公告)日：1995-11-20
申请号：EP94912838
申请日：1994-03-21
申请人： UNIV FLORIDA STATE
发明人： HOLTON ROBERT A , RENGAN KASTHURI
IPC分类号： A61K31/44 , A61P35/00 , A61P35/02 , C07D205/08 , C07D305/14 , C07D401/04 , C07D405/12 , C07D407/12 , C07F7/08 , C07F7/18 , A61K31/335
CPC分类号： C07D405/12 , C07D205/08 , C07D305/14 , C07D407/12 , C07F7/1856 , C07F7/186 , Y02P20/55
摘要： Taxane derivatives having a pyridyl substituted C13 side-chain.
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2.发明公开FURYL OR THIENYL CARBONYL SUBSTITUTED TAXANES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. 失效呋喃基或噻吩基，取代的紫杉烷类化合物及含有药物。
公开(公告)号：EP0669918A4
公开(公告)日：1995-07-10
申请号：EP94900474
申请日：1993-11-01
申请人： UNIV FLORIDA STATE
IPC分类号： A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61P35/00 , A61P35/02 , C07C227/22 , C07C231/12 , C07C233/87 , C07D305/14 , C07D407/12 , C07D409/12 , C07F7/18 , C07D333/10 , A61K31/335 , C07D307/12
CPC分类号： C07D407/12 , C07C227/22 , C07C231/12 , C07C233/87 , C07C2601/14 , C07C2601/16 , C07C2603/62 , C07D305/14 , C07D409/12 , C07F7/1856 , C07F7/186 , Y02P20/55
摘要： Taxane derivatives of formula (3) wherein R1 is phenyl or p-nitrophenyl, R3 is furyl or thienyl, T1 is hydrogen, hydroxyl protecting group, or -COT2, T2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or monocyclic aryl, Ac is acetyl, and E1 and E2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
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3.发明公开TAXANES HAVING FURYL OR THIENYL SUBSTITUTED SIDE-CHAIN 失效紫杉烷MIT FuryL-ODER THIENYL SUBSTITUIERTEN SEITENKETTEN
公开(公告)号：EP0690867A4
公开(公告)日：1996-03-20
申请号：EP94911675
申请日：1994-03-21
申请人： UNIV FLORIDA STATE
发明人： HOLTON ROBERT A , NADIZADEH HOSSAIN , BIEDIGER RONALD J , RENGAN KASTHURI , SUZUKI YUKIO , TAO CHUNLIN , CHAI KI-BYUNG , IDMOUMAZ HAMID
IPC分类号： C07D333/20 , A61K31/335 , A61K31/337 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61P35/00 , A61P35/02 , C07C227/22 , C07C231/12 , C07C233/87 , C07D205/08 , C07D205/085 , C07D205/09 , C07D305/14 , C07D307/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/00 , C07D407/12 , C07D407/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07F7/08 , C07F7/18
CPC分类号： C07D407/12 , C07C227/22 , C07C231/12 , C07C233/87 , C07C2601/14 , C07C2601/16 , C07C2603/62 , C07D205/08 , C07D305/14 , C07D405/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07F7/1856 , C07F7/186 , Y02P20/55
摘要： Taxane derivatives having a C13 side chain which includes a furyl or thienyl substituent.
摘要翻译： 具有包含呋喃基或噻吩基取代基的C13侧链的紫杉烷衍生物。
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公开(公告)号：EP0690711A4
公开(公告)日：1996-03-20
申请号：EP94912286
申请日：1994-03-21
申请人： UNIV FLORIDA STATE
IPC分类号： A61K31/335 , A61K31/337 , A61P35/00 , C07C227/22 , C07C231/12 , C07C233/87 , C07D205/08 , C07D205/085 , C07D305/14 , C07D407/12 , C07D409/12 , C07F7/18
CPC分类号： C07D407/12 , C07C227/22 , C07C231/12 , C07C233/87 , C07C2601/14 , C07C2601/16 , C07C2603/62 , C07D205/08 , C07D305/14 , C07D409/12 , C07F7/1856 , C07F7/186
摘要： Taxanes having side-chain substituted by a group CONX8X10 wherein X8 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterosubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, and X10 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterosubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl. The taxanes are useful anti-cancer and anti-leukemia agents.
摘要翻译： 其中X 8为氢，烷基，烯基，炔基，芳基，杂芳基或杂取代的烷基，烯基，炔基，芳基，杂芳基和X 10为烷基，烯基，炔基，芳基，杂芳基， 或杂取代的烷基，烯基，炔基，芳基，杂芳基。 紫杉烷类是有用的抗癌和抗白血病剂。
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