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公开(公告)号:EP2569291A4
公开(公告)日:2013-10-16
申请号:EP11780012
申请日:2011-05-10
发明人: LI TONG-SHUANG , MCEACHERN ERNEST J , VOCADLO DAVID J , ZHOU YUANXI , ZHU YONGBAO , LIU KUN , SELNICK HAROLD G
IPC分类号: C07D263/52 , A61K31/423 , A61K31/428 , A61P25/28 , C07D263/54 , C07D277/60 , C07D277/82 , C07D413/04 , C07D417/04 , C12Q1/34
CPC分类号: C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
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公开(公告)号:EP2890679A4
公开(公告)日:2016-05-04
申请号:EP13833758
申请日:2013-08-29
IPC分类号: C07D211/60 , A61K31/445 , A61P25/28
CPC分类号: C07D211/60
摘要: The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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3.
公开(公告)号:EP2890678A4
公开(公告)日:2016-01-27
申请号:EP13833184
申请日:2013-08-29
IPC分类号: C07D211/56 , A61K31/445 , A61K31/4523 , A61P25/28 , C07D401/06 , C07D417/06 , C07H13/02 , C12N9/24
CPC分类号: C07D211/56 , A61K31/445 , A61K31/4523 , C07D401/06 , C07D417/06
摘要: The invention provides compounds of Formula (I) for inhibiting gh cosidases, prodrugs of the compounds, and pharmaceutical compositions comprising the compounds or prodrugs of the compounds. The invention also provides method of treating diseases and disorders related to deficiency or over-expression of O-gh coprotein 2-acetamido-2-deoxy-&bgr;-D-glucopyranosidase (O-GlcNAcase), accumulation or deficiency of 2-acetamido-2-deoxy-&bgr;-D-glucopyranoside (O-GlcNAc).
摘要翻译: 本发明提供式(I)化合物,其用于抑制gh辅酶,化合物的前药和包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-gh蛋白2-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖苷酶(O-GlcNAcase)的缺乏或过度表达相关的疾病和病症的方法,2-乙酰氨基-2- 2-脱氧-β-D-吡喃葡萄糖苷(O-GlcNAc)。
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公开(公告)号:EP2890675A4
公开(公告)日:2016-01-13
申请号:EP13834204
申请日:2013-08-29
发明人: MCEACHERN ERNEST J , SUN JIANYU , VOCADLO DAVID J , ZHOU YUANXI , ZHU YONGBAO , SELNICK HAROLD G
IPC分类号: C07D207/12 , A61K31/40 , A61K31/428 , A61K31/4439 , A61P25/28 , C07D401/06 , C07D417/06 , C07H13/02 , C12N9/24
CPC分类号: C07D207/12 , A61K31/40 , A61K31/428 , A61K31/4439 , C07D207/16 , C07D401/06 , C07D417/06 , C12N9/99 , C12Y302/01169
摘要: The invention provides compounds for inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号:EP2726492A4
公开(公告)日:2015-02-25
申请号:EP12805186
申请日:2012-06-27
发明人: LI TONG-SHUANG , MCEACHERN ERNEST J , VOCADLO DAVID J , ZHOU YUANXI , ZHU YONGBAO , SELNICK HAROLD G
IPC分类号: C07H9/06 , A61K31/7056 , C07D513/04 , C12Q1/34 , C12Q1/37 , G01N33/50
CPC分类号: C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N2333/924 , G01N2500/04
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6.SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF 有权
标题翻译: SEREKTIVE GLYCOSIDASEHEMMER UND IHRE VERWENDUNG公开(公告)号:EP2638052A4
公开(公告)日:2014-04-02
申请号:EP11839469
申请日:2011-11-08
发明人: COBURN CRAIG A , LIU KUN , MCEACHERN ERNEST J , MU CHANGWEI , SELNICK HAROLD G , VOCADLO DAVID J , WANG YAODE , WEI ZHONGYONG , ZHOU YUANXI
IPC分类号: C07H9/06 , A61K31/7052 , C07D513/04 , C07D513/14 , C07H13/02 , C07H13/04 , C07H13/12 , C07H15/18 , C12Q1/48 , G01N33/50
CPC分类号: C07D513/14 , C07D513/04 , C07H9/06 , C07H13/04 , C07H13/12 , C07H15/18 , C12Q1/48 , G01N2500/02
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公开(公告)号:EP2847199A4
公开(公告)日:2015-11-11
申请号:EP13787989
申请日:2013-05-03
发明人: SELNICK HAROLD G , LI WENPING , HOSTETLER ERIC , LIU KUN , MCEACHERN ERNEST J , ZHOU YUANXI , WEI ZHONGYONG , MU CHANGWEI , WANG YAODE , CHANG JIANG
IPC分类号: C07D513/04
CPC分类号: C07D513/04 , C07B59/005 , C07B2200/05 , C07H9/06
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公开(公告)号:EP2744338A4
公开(公告)日:2015-01-14
申请号:EP12823924
申请日:2012-08-10
发明人: SELNICK HAROLD G , LIU KUN , MCEACHERN ERNEST J , ZHOU YUANXI , ZHU YONGBAO
IPC分类号: A61K31/42 , C07D263/58 , C07D277/60 , C07D277/82 , C07D413/04 , C07D417/04
CPC分类号: C07D263/58 , A61K31/423 , A61K31/428 , C07D277/60 , C07D277/82 , C07D413/04 , C07D417/04
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公开(公告)号:EP2726468A4
公开(公告)日:2014-11-12
申请号:EP12805139
申请日:2012-06-27
IPC分类号: C07D263/58 , A61K31/423 , C07D277/82 , C12Q1/34 , G01N33/50
CPC分类号: C07D277/60 , C07D263/52 , C07D263/58 , C07D277/82 , C12Q1/37 , G01N2333/924 , G01N2500/04
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公开(公告)号:EP2688899A4
公开(公告)日:2014-08-27
申请号:EP12761443
申请日:2012-03-16
发明人: MCEACHERN ERNEST J , VOCADLO DAVID J , ZHOU YUANXI , COBURN CRAIG A , LIU KUN , SELNICK HAROLD G
IPC分类号: C07H9/06 , A61K31/7056 , C07D513/04 , C07H13/02 , C12N9/24 , C12Q1/34
CPC分类号: C07H9/06 , C07H13/04 , C12Q1/34 , G01N2333/924 , G01N2500/04
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