公开(公告)号：EP2861188A4

公开(公告)日：2016-01-27

申请号：EP13803422

申请日：2013-06-14

申请人： UNIV HONG KONG

发明人： CHAN PUI BARBARA ,  CHIK TSZ KIT ,  CHOY TSZ HANG ANDREW ,  MA XUANYI ,  CHEUNG MAN CHEE KENNETH

IPC分类号： A61F2/44 ,  A61L27/20 ,  A61L27/24 ,  A61L27/38 ,  A61L27/50 ,  A61L27/54

CPC分类号： A61B17/0057 ,  A61B17/00491 ,  A61B17/34 ,  A61B2017/00893 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/64 ,  A61L2400/06 ,  A61M5/31

摘要： The subject invention pertains to medical apparatuses and methods for reducing or preventing leakage of injected therapeutic agents (including liquid-containing substances, cells) into a solid or hollow tissue/organ after puncturing.

公开(公告)号：EP2175978A4

公开(公告)日：2014-08-27

申请号：EP08773021

申请日：2008-07-07

申请人： UNIV HONG KONG

发明人： CHAN PUI BARBARA ,  CHAN CHEUKMING ,  SO KWOKFAI

IPC分类号： B01J13/14 ,  A61K9/16

CPC分类号： B01J13/06 ,  A61K9/1658 ,  A61K9/1694 ,  A61L27/3633 ,  B01J13/14

摘要： A method of manufacture of ECM microparticles incorporating bioactive molecules for drug delivery has been developed, using a modified emulsification method or a water-in-oil-phase-separation method. The microspheres are photochemically crosslinked to control the release of the bioactive molecules for better drug delivery usage without compromising the biocompatibility of the crosslinked structures. The method uses mild fabrication conditions and simple processes, no toxic chemical crosslinking reagent, which may cause cytotoxicity and calcification after implantation, no organic solvents, which may reduce drug availability and bioactivity, and no vigorous stirring action, which may fragmentize material with poor shape and mechanical stability and thus destabilize the emulsion. The resulting microparticles or microspheres are of controlled size, controlled release, highly biocompatible, and useful for drug delivery as well as cell culture.

公开(公告)号：EP2582410A4

公开(公告)日：2014-08-06

申请号：EP11795024

申请日：2011-06-15

申请人： UNIV HONG KONG

发明人： CHAN PUI BARBARA ,  CHENG HIUWA ,  CHIK TSZKIT DANIEL ,  CHEUNG MANCHEE KENNETH ,  LUK DIPKEI KEITH

IPC分类号： A61L27/40 ,  A61L27/38 ,  C12N5/07 ,  C12N5/0735 ,  C12N5/0775 ,  C12N5/0789

CPC分类号： A61L27/3891 ,  A61K35/28 ,  A61K35/51 ,  A61K35/545 ,  A61L27/3834 ,  C12N5/0012 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0697 ,  C12N2502/1311 ,  C12N2502/1317 ,  C12N2502/1358 ,  C12N2527/00 ,  C12N2533/54

摘要： A simple, highly flexible and scalable platform for making functional complex tissues with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naïve subunits, exposing the undifferentiated or naïve subunits to different cell culture environments for induction of differentiation towards different lineages as required by that complex tissue, and combining the then functional subunits with or without the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. The bioengineered tissue graft can then used to replace dysfunctional tissue.