公开(公告)号：EP2077779A4

公开(公告)日：2012-07-25

申请号：EP07816327

申请日：2007-09-13

申请人： UNIV HONG KONG

发明人： YEUNG WAIKWOK KELVIN ,  LU WEIJIA WILLIAM ,  LUK DIPKEI KEITH ,  CHEUNG MANCHEE

IPC分类号： A61B17/70 ,  A61B17/78 ,  C22C19/03 ,  C22F1/10

CPC分类号： A61B17/7032 ,  A61B17/7034 ,  A61B2017/00867

摘要： A mechanism to connect the supporting portions of orthopaedic implants such as in the head, spine, upper limb and lower limb and thereby prevent loosening and fretting at the implant interface of an orthopaedic implant construct has been developed based on shape memory effect and super-elasticity of shape memory materials such as nickel-titanium (nitinol or NiTi) shape-memory-alloy, without the use of typical threaded fastening technique. Advantages are conferred by making the entire device, not just connecting pieces, out of shape memory alloy and having shape memory effect and super-elasticity. Heating the memory head of the device will compress the connection portion without the use of an auxiliary device (e.g. coupling member) so that the connection portion can be completely clamped down by the memory head. Further advantages are provided through the use of a two-way shape memory effect in which the memory device can be closed or tightened by heating up the ambient temperature, and re-opened by cooling down the temperature.

公开(公告)号：EP2164533A4

公开(公告)日：2012-11-28

申请号：EP08772971

申请日：2008-06-23

申请人： UNIV HONG KONG

发明人： LU WEIJIA WILLIAM ,  LI ZHAOYANG ,  LAM WINGMOON RAYMOND ,  LUK DIPKEI KEITH

IPC分类号： A61L27/30 ,  A61K9/14 ,  A61K9/16 ,  A61K33/14 ,  A61L24/00 ,  A61L27/50

CPC分类号： A61K9/1611 ,  A61K9/141 ,  A61K9/143 ,  A61K33/24 ,  A61L24/0068 ,  A61L27/306 ,  A61L27/50 ,  A61L2400/12

公开(公告)号：EP2582410A4

公开(公告)日：2014-08-06

申请号：EP11795024

申请日：2011-06-15

申请人： UNIV HONG KONG

发明人： CHAN PUI BARBARA ,  CHENG HIUWA ,  CHIK TSZKIT DANIEL ,  CHEUNG MANCHEE KENNETH ,  LUK DIPKEI KEITH

IPC分类号： A61L27/40 ,  A61L27/38 ,  C12N5/07 ,  C12N5/0735 ,  C12N5/0775 ,  C12N5/0789

CPC分类号： A61L27/3891 ,  A61K35/28 ,  A61K35/51 ,  A61K35/545 ,  A61L27/3834 ,  C12N5/0012 ,  C12N5/0654 ,  C12N5/0655 ,  C12N5/0697 ,  C12N2502/1311 ,  C12N2502/1317 ,  C12N2502/1358 ,  C12N2527/00 ,  C12N2533/54

摘要： A simple, highly flexible and scalable platform for making functional complex tissues with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naïve subunits, exposing the undifferentiated or naïve subunits to different cell culture environments for induction of differentiation towards different lineages as required by that complex tissue, and combining the then functional subunits with or without the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. The bioengineered tissue graft can then used to replace dysfunctional tissue.