公开(公告)号：EP2999494A4

公开(公告)日：2017-01-18

申请号：EP14800261

申请日：2014-05-19

申请人： UNIV YALE

发明人： DIMITRIEVSKA SASHKA ,  NIKLASON LAURA

IPC分类号： A61L31/08

CPC分类号： A61L27/507 ,  A61K31/727 ,  A61K35/44 ,  A61L27/34 ,  A61L27/3625 ,  A61L27/52 ,  A61L27/54 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0064 ,  A61L33/08 ,  A61L2300/236 ,  A61L2300/42 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  A61L2430/40 ,  B05D7/54 ,  C08L5/08

摘要： The present invention provides anti-thrombogenic compositions, including anti-thrombogenic vascular grafts. In certain embodiments, the compositions comprise decellularized tissue coated with an anti-thrombogenic coating. The present invention also provides methods of preparing anti-thrombogenic compositions and methods of treatment comprising implanting the anti-thrombogenic compositions into a subject in need thereof.

摘要翻译： 本发明提供抗血栓形成组合物，包括抗血栓形成血管移植物。 在某些实施方案中，组合物包含涂有抗血栓形成包衣的脱细胞组织。 本发明还提供了制备抗血栓形成组合物和治疗方法的方法，包括将抗血栓形成组合物植入有需要的受试者。

公开(公告)号：EP3094720A4

公开(公告)日：2017-08-02

申请号：EP15737803

申请日：2015-01-14

申请人： UNIV YALE

发明人： GHAEDI MAHBOOBE ,  NIKLASON LAURA

IPC分类号： C12N5/071 ,  A61K35/36 ,  A61P11/00 ,  C12N5/074

CPC分类号： C12N5/0688 ,  A61K35/36 ,  C12N5/0689 ,  C12N2500/99 ,  C12N2501/115 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/415 ,  C12N2506/45

摘要： The present invention provides compositions and methods of preparing airway cells. In one aspect, an epithelial airway cell derived from an induced pluripotent stem (iPS) cell characterized by expression of airway cell surface markers and an ability to proliferate is described. In another aspect, methods of differentiating an iPS into an epithelial airway cell is provided. Engineered lungs, methods of making such engineered lungs comprising the epithelial airway cells and treating respiratory disorders are also disclosed.

摘要翻译： 本发明提供了制备气道细胞的组合物和方法。 在一个方面，描述了来自诱导多能干（iPS）细胞的上皮细胞气道细胞，其特征在于气道细胞表面标记的表达和增殖能力。 另一方面，提供了将iPS分化成上皮细胞气道细胞的方法。 也公开了工程化的肺，制造包含上皮细胞气道细胞和治疗呼吸系统疾病的工程化肺的方法。

公开(公告)号：EP2943208A4

公开(公告)日：2016-09-21

申请号：EP14738132

申请日：2014-01-08

申请人： UNIV YALE ,  RAREDON RESOURCES INC

发明人： RAREDON MICHA SAM BRICKMAN ,  RAREDON TOM ,  NIKLASON LAURA

IPC分类号： A61K35/42 ,  A01N1/00 ,  A01N63/00 ,  A61L27/38 ,  C12M1/00 ,  C12M3/00 ,  G01N33/50

CPC分类号： A01N1/0263 ,  A61K35/42 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  A61L2430/40 ,  C12M21/08 ,  C12M23/00 ,  C12M23/50 ,  C12M23/52 ,  C12M25/14 ,  C12M29/10 ,  C12M41/46 ,  C12M41/48 ,  C12N5/0688 ,  C12N2533/90 ,  G01N33/5088

摘要： The present invention provides a bioreactor for large-mammal lung tissue. The bioreactor is capable of hydraulic driven negative-pressure and positive-pressure perfusion and ventilation. Perfusion and ventilation is delivered at physiological rates and is easily controllable. In one embodiment, the bioreactor comprises a support scaffold to support the size of a large-mammal lung tissue. In another embodiment, the bioreactor comprises a pleural sack that provides a small isolated fluid chamber which surrounds an engineered lung, thereby minimizing the amount of culture media needed. The present invention also provides an in vitro model for examining the function of a test agent and compositions and methods for alleviating a lung defect in a large-mammal.