公开(公告)号：EP3256180A1

公开(公告)日：2017-12-20

申请号：EP16705218.2

申请日：2016-02-10

申请人： UPM-Kymmene Corporation

发明人： YLIPERTTULA, Marjo ,  LAUREN, Patrick ,  SOMERSALO, Petter ,  LOU, Yanru

IPC分类号： A61L27/26 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L29/08 ,  A61L29/14 ,  A61L29/16 ,  A61L31/04 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L17/14

CPC分类号： A61L17/145 ,  A61L27/26 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L29/085 ,  A61L29/145 ,  A61L29/148 ,  A61L29/16 ,  A61L31/041 ,  A61L31/10 ,  A61L31/145 ,  A61L31/148 ,  A61L31/16 ,  C08B1/003 ,  C08B37/0084 ,  C08L1/02 ,  C08L5/04

摘要： The present invention relates to the use of nanofibrillar cellulose hydrogel in cell culture and medical applications. The invention relates to a composition comprising nanofibrillar cellulose, cross linkable polymer and at least one bioactive agent. The invention also provides methods for producing the composition and uses thereof. The present invention further relates to the use of said composition for manufacturing of a shaped matrix, the method of preparing said matrix, the matrix and the use of said matrix in various applications.

公开(公告)号：EP3234600A1

公开(公告)日：2017-10-25

申请号：EP15823519.2

申请日：2015-12-18

申请人： UPM-Kymmene Corporation

发明人： YLIPERTTULA, Marjo ,  URTTI, Arto ,  LOU, Yan-Ru ,  MALINEN, Melina ,  LAURÉN, Patrick ,  KANNINEN, Liisa ,  NIKLANDER, Johanna ,  SOMERSALO, Petter ,  HARJUMÄKI, Riina

IPC分类号： G01N33/50 ,  G01N33/543

CPC分类号： G01N33/5082 ,  G01N33/5008 ,  G01N33/5014 ,  G01N33/5023 ,  G01N33/5026 ,  G01N33/5436 ,  G01N2800/52

摘要： optionally within another plant-derived NFC hydrogel; incubating the exposed in vivo like cells; detecting during or after incubating, the impact of the test chemical on the in vivo like cells by at least one detection; and removing the plant-derived NFC hydrogel at least once at any stage after obtaining the in vivo like cells and before at least one detection used for detecting the impact of the test chemical on the in vivo like cells. The invention further relates to the use of plant-derived NFC hydrogel in a method for chemical testing, the use of in vivo like cells obtained by culturing cells in plant-derived NFC hydrogel for chemical testing and to a kit for chemical testing comprising plant-derived NFC hydrogel, instructions and a cell or test chemical library.

摘要翻译： 本发明涉及用于化学测试的方法，包括在第一植物衍生的纳米纤维状纤维素（NFC）水凝胶中培养细胞以获得体内类似细胞; 将体内样细胞暴露于测试化学品; 任选地在另一植物衍生的NFC水凝胶内; 温育暴露的体内样细胞; 通过至少一次检测在培养期间或之后检测测试化学品对体内样细胞的影响; 以及在获得体内样细胞后以及在用于检测测试化学品对体内样细胞的影响的至少一种检测之前的任何阶段，将植物衍生的NFC水凝胶至少移除一次。 本发明进一步涉及植物衍生的NFC水凝胶在用于化学测试的方法中的用途，通过在源自植物的NFC水凝胶中培养细胞获得的体内用于化学测试的细胞的用途以及用于化学测试的用于化学测试的试剂盒， 衍生的NFC水凝胶，说明书和细胞或测试化学品库。