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1.发明公开
公开(公告)号：EP4380600A1
公开(公告)日：2024-06-12
申请号：EP22757593.3
申请日：2022-07-29
申请人： Universidade de Santiago de Compostela , Centre National de la Recherche Scientifique (CNRS) , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Université d'Angers
发明人： MILBANK, Edward , LÓPEZ PÉREZ, Miguel Antonio , MARTINEZ MARTINEZ, María Del Carmen , ANDRIANTSITOHAINA, Ramaroson
IPC分类号： A61K38/45 , A61P3/04 , A61K35/15 , C12N15/52 , C12N5/0784
CPC分类号： A61K38/45 , C12Y207/11026 , A61P3/04 , A61K35/15 , C12N5/0639 , A61K48/0041 , A01K2227/10520130101 , A01K2217/07520130101
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2.发明公开
公开(公告)号：EP4137148A1
公开(公告)日：2023-02-22
申请号：EP21382763.7
申请日：2021-08-17
申请人： Universidade de Santiago de Compostela , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université d'Angers
发明人： MILBANK, Edward , LÓPEZ PÉREZ, Miguel Antonio , MARTINEZ MARTINEZ, María Del Carmen , ANDRIANTSITOHAINA, Ramaroson
IPC分类号： A61K38/45 , A61P3/04 , A61K35/15 , C12N15/52 , C12N5/0784
摘要： The present invention relates to a population of small extracellular vesicles (sEVs) for use in the treatment of obesity in a subject in need thereof, wherein the sEVs comprise at least one polynucleotide encoding a dominant negative AMP-activated protein kinase alpha 1 (AMPKα1-DN) mutant protein operably linked and under the control of a steroidogenic factor 1 (SF1) promoter, wherein the sEVs are engineered to transiently express in their outer membrane at least one fusion protein comprising the neurotrophic rabies virus (RVG) peptide fused to lysosome-associated membrane protein 2b. Said population is highly safe and effective, as the sEVs, when administered systematically, are capable of exert their effect in the SF1 expressing neurons located in the ventromedial nucleus of the hypothalamus.
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3.发明公开METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE CARDIOPROTECTION 有权VERFAHREN UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN ZUR KARDIOPROTEKTION
公开(公告)号：EP2943212A1
公开(公告)日：2015-11-18
申请号：EP14700845.2
申请日：2014-01-14
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , UNIVERSITE DE MONTPELLIER , Université Montpellier 2, Sciences et Techniques , Assistance Publique Hôpitaux De Paris , Université d'Angers , Université Paris-Est Créteil Val de Marne
发明人： LACAMPAGNE, Alain , THIREAU, Jérôme , CAZORLA, Olivier , LE GUENNEC, Jean-Yves , FAUCONNIER, Jérémy , MARTINEZ, Maria Del Carmen , ANDRIANTSITOHAINA, Ramaroson , GALEH-MARZBAN, Bijan , SOLETI, Raffaella
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/16 , A61P9/06 , A61P9/10 , C07K14/47 , C07K14/4705 , C07K2319/30
摘要： The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
摘要翻译： 本发明涉及心脏保护用于经历心肌梗塞的受试者的方法和药物组合物。 特别地，本发明涉及用于经历心肌梗塞的受试者的心脏保护的声音刺猬蛋白信号传导途径的配体。
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公开(公告)号：EP2943212B8
公开(公告)日：2018-05-16
申请号：EP14700845.2
申请日：2014-01-14
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , UNIVERSITE DE MONTPELLIER , Assistance Publique Hôpitaux De Paris , Université d'Angers , Université Paris-Est Créteil Val de Marne
发明人： LACAMPAGNE, Alain , THIREAU, Jérôme , CAZORLA, Olivier , LE GUENNEC, Jean-Yves , FAUCONNIER, Jérémy , MARTINEZ, Maria Del Carmen , ANDRIANTSITOHAINA, Ramaroson , GALEH-MARZBAN, Bijan , SOLETI, Raffaella
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/16 , A61P9/06 , A61P9/10 , C07K14/47 , C07K14/4705 , C07K2319/30
摘要： The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
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公开(公告)号：EP2943212B1
公开(公告)日：2018-03-28
申请号：EP14700845.2
申请日：2014-01-14
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , UNIVERSITE DE MONTPELLIER , Université Montpellier 2, Sciences et Techniques , Assistance Publique Hôpitaux De Paris , Université d'Angers , Université Paris-Est Créteil Val de Marne
发明人： LACAMPAGNE, Alain , THIREAU, Jérôme , CAZORLA, Olivier , LE GUENNEC, Jean-Yves , FAUCONNIER, Jérémy , MARTINEZ, Maria Del Carmen , ANDRIANTSITOHAINA, Ramaroson , GALEH-MARZBAN, Bijan , SOLETI, Raffaella
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/16 , A61P9/06 , A61P9/10 , C07K14/47 , C07K14/4705 , C07K2319/30
摘要： The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
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