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公开(公告)号：EP1706390A2
公开(公告)日：2006-10-04
申请号：EP05702217.0
申请日：2005-01-12
发明人： SCILIMATI, Antonio , DI NUNNO, Leonardo , VITALE, Paola , PATRIGNANI, Paola , TACCONELLI, Stefania , PORRECA, Ettore , STUPPIA, Liborio
IPC分类号： C07D261/00
CPC分类号： C07D261/08 , C07D413/04
摘要： The present invention refers to isoxazole derivatives, in particular 3,4-diaryl isoxazole derivatives, to their pharmaceutical compositions, the process for preparing them and their use as inhibitors of cycloosygenase, in particular of cycloosygenase 1 and 2 (COX-1) (COX-2). The present invention also refers to a process for determining the potential toxicity of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) isoform, and to the use of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) and their pharmaceutical compositions, in subjects for whom the potential cardiovascular toxicity of said compounds is reduced.
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公开(公告)号：EP2948187B1
公开(公告)日：2019-10-16
申请号：EP14708640.9
申请日：2014-01-23
IPC分类号： A61K51/04 , A61K31/4155 , A61K31/42 , C07D261/08 , C07D261/14 , C07D405/04 , A61P35/00 , A61P29/00
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公开(公告)号：EP1706390B1
公开(公告)日：2010-05-19
申请号：EP05702217.0
申请日：2005-01-12
发明人： SCILIMATI, Antonio c/o Dipt. Farmaco-Chimico , DI NUNNO, Leonardo c/o Dipt. Farmaco-Chimico , VITALE, Paola , PATRIGNANI, Paola , TACCONELLI, Stefania , PORRECA, Ettore , STUPPIA, Liborio
IPC分类号： C07D261/00
CPC分类号： C07D261/08 , C07D413/04
摘要： The present invention refers to isoxazole derivatives, in particular 3,4-diaryl isoxazole derivatives, to their pharmaceutical compositions, the process for preparing them and their use as inhibitors of cycloosygenase, in particular of cycloosygenase 1 and 2 (COX-1) (COX-2). The present invention also refers to a process for determining the potential toxicity of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) isoform, and to the use of compounds that inhibit cycloosygenase (COX), in particular cycloosygenase-2 (COX-2) and their pharmaceutical compositions, in subjects for whom the potential cardiovascular toxicity of said compounds is reduced.
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公开(公告)号：EP4198027A1
公开(公告)日：2023-06-21
申请号：EP22213255.7
申请日：2022-12-13
发明人： QUIVELLI, Andrea Francesca , CAPRIATI, Vito , PERNA, Filippo Maria , VITALE, Paola , ROSSI, Federico Vittorio , GARCÍA - ÁLVAREZ, Joaquín
IPC分类号： C07D239/42 , C07D333/20 , C07D409/12
摘要： The present invention relates to a sustainable synthetic process for obtaining ethylenediamines molecules with antihistamine activity whose production costs are considerably reduced by employing unconventional biodegradable solvents, such as the Deep Eutectic Solvents, with considerable advantages from a point of view both of the environmental and economic impact.
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5.发明公开HETEROCYCLES AND THEIR RADIOLABELED ANALOGS USEFUL AS COX-1 SELECTIVE INHIBITORS 审中-公开杂环及其RADIO注明物作为选择性COX-1抑制剂
公开(公告)号：EP2948187A1
公开(公告)日：2015-12-02
申请号：EP14708640.9
申请日：2014-01-23
IPC分类号： A61K51/04 , A61K31/4155 , A61K31/42 , C07D231/10 , C07D261/08 , C07D261/14 , A61P35/00 , A61P29/00
摘要： The present invention relates to novel heterocycles which are potent and selective inhibitors of cyclooxygenase-1 (COX-1) and to their radiolabeled derivatives thereof which are both useful as theranostics of a number of pathologies.
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