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公开(公告)号：EP3233897A1
公开(公告)日：2017-10-25
申请号：EP15816783.3
申请日：2015-12-21
申请人： Universite de Nantes , Chu Nantes , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： HEYMANN, Dominique , SEGALINY, Aude , BRION, Régis
IPC分类号： C07K14/54 , C07K14/715 , C07K16/24 , A61K39/00
CPC分类号： C07K16/244 , A01K67/0275 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/54
摘要： The present disclosure relates to novel anti IL-34 antibodies or antigen-binding fragments thereof specifically binding cytokine IL-34 with high affinity, the method of obtaining of these antibodies and their therapeutic use.
摘要翻译： 本公开涉及以高亲和力特异性结合细胞因子IL-34的新型抗IL-34抗体或其抗原结合片段，获得这些抗体的方法及其治疗用途。
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2.发明公开
公开(公告)号：EP4112060A1
公开(公告)日：2023-01-04
申请号：EP21183145.8
申请日：2021-07-01
申请人： Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER) , Institut de Cancérologie de l'Ouest (I.C.O) , Universite de Nantes , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： COLLIEC-JOUAULT, Sylvia , SINQUIN, Corinne , MUNOZ GARCIA, Javier , HEYMANN, Dominique , ZYKWINSKA, Agata
IPC分类号： A61K31/737 , A61P35/00
摘要： The invention provides low-molecular-weight non-sulfated or sulfated exopolysaccharide derivatives prepared from a marine native exopolysaccharide excreted by a mesophilic marine bacterium from a deep-sea hydrothermal environment (the HE800 strain, a Vibrio diabolicus species of the Vibrio genus), and relates to the use of such low-molecular-weight exopolysaccharide derivatives for the treatment of cancer.
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3.发明公开
公开(公告)号：EP4362956A1
公开(公告)日：2024-05-08
申请号：EP22733682.3
申请日：2022-07-01
申请人： Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) , Institut de Cancérologie de l'Ouest , Nantes Université , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： COLLIEC-JOUAULT, Sylvia , SINQUIN, Corinne , MUNOZ GARCIA, Javier , HEYMANN, Dominique , ZYKWINSKA, Agata
IPC分类号： A61K31/737 , A61P35/00 , A61K31/704
CPC分类号： A61K31/737 , A61P35/00 , A61K31/704
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4.发明授权PEPTIDES TARGETING RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B (RANK) AND THEIR APPLICATIONS 有权ON RANK（核因子κB受体激活）靶向的肽及其应用
公开(公告)号：EP2812015B1
公开(公告)日：2016-04-13
申请号：EP12810302.5
申请日：2012-12-21
申请人： Universite de Nantes , Chu Nantes
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5.发明公开PEPTIDES TARGETING RECEPTOR ACTIVATOR OF NUCLEAR FACTOR -KAPPA B (RANK) AND THEIR APPLICATIONS 有权ON RANK（核因子κB受体激活）靶向的肽及其应用
公开(公告)号：EP2812015A1
公开(公告)日：2014-12-17
申请号：EP12810302.5
申请日：2012-12-21
申请人： Universite de Nantes , Chu Nantes
CPC分类号： C07K7/06 , A61K38/04 , A61K38/08 , A61K38/10 , A61K45/06 , A61K47/48215 , A61K47/60 , C07K7/08
摘要： The present invention relates to a polypeptide for use as a medicament in the treatment and/or prevention of a disease wherein the RANKL-RANK signaling pathway is involved, in particular a bone resorptive disease.
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6.发明公开DERIVES D'ACIDE HYDROXY-BISPHOSPHONIQUE COMME VECTEUR CIBLANT LE TISSU OSSEUX 有权羟基二膦酸衍生物比骨组织LOOKING VECTORS
公开(公告)号：EP2240501A1
公开(公告)日：2010-10-20
申请号：EP09700113.5
申请日：2009-01-05
申请人： Université de Nantes , Chu Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： EGOROV, Maxim , FORTUN, Yannick , HEYMANN, Dominique , LEBRETON, Jacques , MATHE, Monique , PADRINES, Marc , REDINI, Françoise
IPC分类号： C07F9/38 , A61K31/663 , A61P35/00 , A61P19/10 , A61P3/14
CPC分类号： C07F9/3873 , C07F9/5728
摘要： The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: - n and m denote, independently of one another, an integer ranging from 1 to 4, - X denotes an oxygen atom or an N-R3 group, - R1 and R3 denote, independently of one another, a linear or branched C1 to C6 alkyl group, and - R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof.
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7.发明授权DERIVES D'ACIDE HYDROXY-BISPHOSPHONIQUE COMME VECTEUR CIBLANT LE TISSU OSSEUX 有权羟基二膦酸衍生物比骨组织LOOKING VECTORS
公开(公告)号：EP2240501B1
公开(公告)日：2015-10-14
申请号：EP09700113.5
申请日：2009-01-05
申请人： Université de Nantes , CHU Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： EGOROV, Maxim , FORTUN, Yannick , HEYMANN, Dominique , LEBRETON, Jacques , MATHE, Monique , PADRINES, Marc , REDINI, Françoise
IPC分类号： C07F9/38 , A61K31/663 , A61P35/00 , A61P19/10 , A61P3/14
CPC分类号： C07F9/3873 , C07F9/5728
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公开(公告)号：EP2240500B1
公开(公告)日：2014-10-01
申请号：EP09700083.0
申请日：2009-01-05
申请人： Université de Nantes , CHU Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： EGOROV, Maxim , FORTUN, Yannick , HEYMANN, Dominique , LEBRETON, Jacques , MATHE, Monique , PADRINES, Marc , REDINI, Françoise
IPC分类号： C07F9/38
CPC分类号： C07F9/386 , C07F9/3873 , C07F9/5728
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公开(公告)号：EP2240500A1
公开(公告)日：2010-10-20
申请号：EP09700083.0
申请日：2009-01-05
申请人： Université de Nantes , Chu Nantes , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Centre National de la Recherche Scientifique (CNRS)
发明人： EGOROV, Maxim , FORTUN, Yannick , HEYMANN, Dominique , LEBRETON, Jacques , MATHE, Monique , PADRINES, Marc , REDINI, Françoise
IPC分类号： C07F9/38
CPC分类号： C07F9/386 , C07F9/3873 , C07F9/5728
摘要： The present invention relates to a method for preparing a hydroxy-bisphosphonic acid derivative or a salt thereof, from the corresponding carboxylic acid, comprising the following steps: - activation of the carboxylic acid function in the form of the boronate derivative thereof through the action of a borane, then - reaction with tris(trimethylsilyl)phosphite, under Arbuzov conditions - treatment with an alcohol, chosen in particular from an aliphatic alcohol or trifluoromethanol, and - separation of the hydroxy-bisphosphonic acid derivative formed, from the reaction medium.
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