公开(公告)号：EP2373980B1

公开(公告)日：2014-03-12

申请号：EP09796423.3

申请日：2009-12-15

申请人： University College Cardiff Consultants, Ltd.

发明人： BORRI, Paola ,  LANGBEIN, Wolfgang ,  MASIA, Francesco

IPC分类号： G01N21/55 ,  B82Y20/00 ,  G01B11/24 ,  G02B21/00 ,  G02B5/00 ,  G01N33/543

CPC分类号： G01N33/54373 ,  B82Y20/00 ,  G01B11/2441 ,  G01N21/554 ,  G02B5/008 ,  G02B21/00 ,  G02F1/33 ,  G02F1/3526 ,  G02F1/3536 ,  G02F2202/36 ,  G02F2203/10

公开(公告)号：EP3658894A1

公开(公告)日：2020-06-03

申请号：EP18749071.9

申请日：2018-07-19

申请人： University College Cardiff Consultants Ltd

发明人： BORRI, Paola ,  LANGBEIN, Wolfgang Werner ,  ZILLI, Attilio ,  PAYNE, Lukas Menezes

IPC分类号： G01N21/31 ,  G02B21/12 ,  G01N15/14 ,  G01N21/53 ,  G01N21/21 ,  G01N21/64

公开(公告)号：EP2409140B1

公开(公告)日：2016-05-04

申请号：EP10711255.9

申请日：2010-03-19

申请人： University College Cardiff Consultants Ltd

发明人： LANGBEIN, Wolfgang ,  BORRI, Paola

IPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/44

CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/44 ,  G01N2021/653

公开(公告)号：EP2409140A1

公开(公告)日：2012-01-25

申请号：EP10711255.9

申请日：2010-03-19

申请人： University College Cardiff Consultants, Ltd.

发明人： LANGBEIN, Wolfgang ,  BORRI, Paola

IPC分类号： G01N21/65 ,  G01J3/44

CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0224 ,  G01J3/44 ,  G01N2021/653

摘要： A coherent anti-Stokes Raman spectroscopy (CARS) system (10) comprises a laser light source (14) for emitting pulsed light, a dichroic beam splitter (18) for splitting a light pulse from the light source into a pump pulse (22) and a Stokes pulse (20) and directing these pulses along respective distinct paths, chirping means, e.g. dispersive glass blocks (24, 30), for chirping the pump and Stokes pulses, directing means for directing the chirped pump and Stokes samples to a sample in time overlap, and detecting means for detecting light stimulated from the sample by the interaction of the pump and Stokes pulses. The system may comprise means, e.g. a reflector (32) connected to a linear motor (34), for adjusting the period between the arrival at the sample of the starts of the chirped pump and Stokes pulses. The system may further comprise a pulse replicating unit for converting a pulse from the light source into a plurality of pulses distributed in time.

公开(公告)号：EP2373980A1

公开(公告)日：2011-10-12

申请号：EP09796423.3

申请日：2009-12-15

申请人： University College Cardiff Consultants, Ltd.

发明人： BORRI, Paola ,  LANGBEIN, Wolfgang ,  MASIA, Francesco

IPC分类号： G01N21/55 ,  G01N33/543 ,  G01N21/65

CPC分类号： G01N33/54373 ,  B82Y20/00 ,  G01B11/2441 ,  G01N21/554 ,  G02B5/008 ,  G02B21/00 ,  G02F1/33 ,  G02F1/3526 ,  G02F1/3536 ,  G02F2202/36 ,  G02F2203/10

摘要： Laser pulses are applied to surface plasmon resonant articles such as gold nanoparticles within a microscopy sample to generate a four-wave mixing signal that is detected as the output of the microscopy process.

公开(公告)号：EP1949104A2

公开(公告)日：2008-07-30

申请号：EP06808501.8

申请日：2006-11-10

申请人： University College Cardiff Consultants, Ltd.

发明人： DALE, Trevor, Clive ,  HARWOOD, Adrian, John ,  BORRI, Paola

IPC分类号： G01N33/53

CPC分类号： G01N33/557 ,  B82Y15/00 ,  B82Y30/00 ,  C12N15/1055 ,  G01N33/5306 ,  G01N33/543 ,  G01N33/54373

摘要： The invention provides a method of measuring the affinity of first and second biomolecules in which a first biomolecule is tethered by a first tether portion having a first tether portion length and a second biomolecule is tethered by a second tether portion having a second tether portion length, the method comprising determining binding of adjacent first and second biomolecules to each other, varying at least one of the first and second tether lengths and determining binding of the first and second biomolecules. The invention also provides apparatus suitable for use in the method of the invention.