公开(公告)号：EP1082444B1

公开(公告)日：2007-08-08

申请号：EP99924404.9

申请日：1999-05-20

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： ENGELHARDT, John, F. ,  DUAN, Dongsheng

IPC分类号： C12N15/86 ,  C12N15/10 ,  C12N5/10 ,  C07K14/47 ,  A01K67/027 ,  A61K31/70 ,  A61K48/00

CPC分类号： C12N15/86 ,  A01K2217/05 ,  A61K48/00 ,  A61K48/0008 ,  C07K14/4712 ,  C12N15/10 ,  C12N15/64 ,  C12N2750/14143

摘要： The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.

公开(公告)号：EP1190249A2

公开(公告)日：2002-03-27

申请号：EP00944624.6

申请日：2000-06-08

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： ENGELHARDT, John, F. ,  DUAN, Dongsheng

IPC分类号： G01N33/50 ,  G01N33/569 ,  A61K38/55 ,  A61K48/00 ,  C12N15/86

CPC分类号： G01N33/5067 ,  A61K31/198 ,  A61K31/27 ,  A61K31/365 ,  A61K31/407 ,  A61K31/4184 ,  A61K31/4706 ,  A61K48/00 ,  C12N2799/025 ,  C12Q1/025 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5044 ,  G01N33/56983 ,  G01N2333/015 ,  G01N2333/075 ,  G01N2333/8139 ,  G01N2333/96466

摘要： Agents and methods to alter rAAV transduction are provided.

公开(公告)号：EP1224313A1

公开(公告)日：2002-07-24

申请号：EP00970689.6

申请日：2000-10-06

申请人： University of Iowa Research Foundation

发明人： ENGELHARDT, John, F. ,  DUAN, Dongsheng ,  YAN, Ziyang

IPC分类号： C12N15/864 ,  C12N7/01 ,  C12N5/10 ,  A61K48/00

CPC分类号： C12N15/86 ,  A61K48/00 ,  C12N2750/14143 ,  C12N2800/108 ,  C12N2830/38 ,  C12N2840/203 ,  C12N2840/44 ,  C12N2840/445

摘要： The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.

公开(公告)号：EP1082444A1

公开(公告)日：2001-03-14

申请号：EP99924404.9

申请日：1999-05-20

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION ,  Engelhardt, John F. ,  Duan, Dongsheng

发明人： ENGELHARDT, John, F. ,  DUAN, Dongsheng

IPC分类号： C12N15/86 ,  C12N15/10 ,  C12N5/10 ,  C07K14/47 ,  A01K67/027 ,  A61K31/70 ,  A61K48/00

CPC分类号： C12N15/86 ,  A01K2217/05 ,  A61K48/00 ,  A61K48/0008 ,  C07K14/4712 ,  C12N15/10 ,  C12N15/64 ,  C12N2750/14143

摘要： The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.