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公开(公告)号：EP0981600A1
公开(公告)日：2000-03-01
申请号：EP99907641.7
申请日：1999-03-11
发明人： ARISTIDOU, Aristos , LONDESBOROUGH, John , PENTTILÄ, Merja , RICHARD, Peter , RUOHONEN, Laura , SÖDERLUND, Hans , TELEMAN, Anita , TOIVARI, Mervi
CPC分类号： C12N9/0016 , C12N9/0006 , C12N9/1025 , C12N9/1205 , C12P7/06 , C12P7/18 , C12P7/625 , C12P13/04 , C12P13/08 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to genetic engineering of production microorganisms used in biotechnology to improve their properties so that they produce useful products more efficiently. The microorganisms express at least one enzyme that causes the functional coupling of the oxidation and reduction of substrates by two pyridine nucleotide-linked dehydrogenase reactions with different specificities for the NAD/NADH and NADP/NADPH coenzyme couples and so facilitates the transfer of electrons between the two coenzyme couples through the said substrates. In particular the invention relates to increasing the yields of products such as ethanol or amino acids from carbon and nitrogen sources such as biomass comprising hexoes, pentoses or their polymers.
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公开(公告)号：EP0981600B1
公开(公告)日：2006-12-13
申请号：EP99907641.7
申请日：1999-03-11
发明人： ARISTIDOU, Aristos , LONDESBOROUGH, John , PENTTILÄ, Merja , RICHARD, Peter , RUOHONEN, Laura , SÖDERLUND, Hans , TELEMAN, Anita , TOIVARI, Mervi
CPC分类号： C12N9/0016 , C12N9/0006 , C12N9/1025 , C12N9/1205 , C12P7/06 , C12P7/18 , C12P7/625 , C12P13/04 , C12P13/08 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to genetic engineering of production microorganisms used in biotechnology to improve their properties so that they produce useful products more efficiently. The microorganisms express at least one enzyme that causes the functional coupling of the oxidation and reduction of substrates by two pyridine nucleotide-linked dehydrogenase reactions with different specificities for the NAD/NADH and NADP/NADPH coenzyme couples and so facilitates the transfer of electrons between the two coenzyme couples through the said substrates. In particular the invention relates to increasing the yields of products such as ethanol or amino acids from carbon and nitrogen sources such as biomass comprising hexoes, pentoses or their polymers.
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