公开(公告)号：EP2968380A4

公开(公告)日：2017-03-22

申请号：EP14763047

申请日：2014-03-17

申请人： VENKATESWARA-RAO KONDAPAVULUR T ,  STEIN EMILY A ,  EVANS MICHAEL A ,  WHOLEY MARK H

发明人： VENKATESWARA-RAO KONDAPAVULUR T ,  STEIN EMILY A ,  EVANS MICHAEL A ,  WHOLEY MARK H

IPC分类号： A61K9/70 ,  A61K31/7048 ,  A61M25/01 ,  A61P5/50 ,  A61P9/04 ,  A61P9/06 ,  A61P9/12 ,  A61P13/12

CPC分类号： A61K31/7048 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/416

公开(公告)号：EP2770992A4

公开(公告)日：2015-12-30

申请号：EP12844191

申请日：2012-10-25

申请人： STEIN EMILY A ,  SWANSON CHRISTINA D ,  EVANS MICHAEL A ,  VENKATESWARA-RAO KONDAPAVULUR T

发明人： STEIN EMILY A ,  SWANSON CHRISTINA D ,  EVANS MICHAEL A ,  VENKATESWARA-RAO KONDAPAVULUR T

IPC分类号： A61K31/401 ,  A61K31/405 ,  A61K31/704 ,  A61P9/02

CPC分类号： A61K31/7048 ,  A61K9/0012 ,  A61K31/401 ,  A61K31/405 ,  A61K31/4166 ,  A61K31/55 ,  A61K33/14 ,  A61K38/1787 ,  A61K45/06 ,  A61M25/0084 ,  A61M25/10 ,  A61M2025/0086 ,  A61M2025/1093 ,  A61K2300/00

摘要： Agents, methods, and devices for affecting nerve function are described. One embodiment of an agent includes a cardiac glycoside, an ACE inhibitor, and an NSAID. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One embodiment of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing.

摘要翻译： 描述了影响神经功能的药剂，方法和装置。 药剂的一个实施方案包括心脏糖苷，ACE抑制剂和NSAID。 药剂可以局部特异性方式局部递送至目标神经或神经的一部分。 例如，该药物可以局部递送至肾神经以损害其功能并治疗高血压。 输送装置的一个实施例包括由气囊支撑的一个或多个针壳体。 输送针可滑动地设置在每个针壳体的针内腔内。

公开(公告)号：EP2968083A4

公开(公告)日：2016-12-07

申请号：EP14775784

申请日：2014-03-12

申请人： STEIN EMILY A

发明人： STEIN EMILY A

IPC分类号： A61K8/18 ,  A61K9/06 ,  A61Q11/00

CPC分类号： A61K8/738 ,  A61K8/11 ,  A61K8/19 ,  A61K8/365 ,  A61K8/41 ,  A61K8/44 ,  A61K8/4926 ,  A61K8/55 ,  A61K8/64 ,  A61K8/66 ,  A61K8/67 ,  A61K8/73 ,  A61K9/0063 ,  A61K2800/51 ,  A61K2800/592 ,  A61Q11/00 ,  A61Q17/005

摘要： Non-toxic consumable compositions and formulations having chelator and base are disclosed with synergistic effects on microbial metabolism and/or growth and/or pathogenic effectors and their use to promote and maintain health in mammals. The non-toxic consumable compositions have more than one chelator and/or more than one base. Methods for selecting said chelator and base composition and methods for detecting conditions in which selected compositions may be used are also disclosed. The synergistic compositions and methods can be used for maintaining health, promoting health and treating diseases.