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公开(公告)号：EP3246035A1
公开(公告)日：2017-11-22
申请号：EP17154220.2
申请日：2011-01-26
IPC分类号： A61K31/7048 , A61K31/198 , A61K31/55 , A61K45/06 , A61M25/06 , A61M25/00 , A61K39/00 , A61P9/12
CPC分类号： A61M25/0084 , A61B5/0215 , A61B5/4094 , A61B5/4839 , A61B2017/22054 , A61B2017/22061 , A61B2017/22067 , A61B2090/378 , A61B2090/3784 , A61K31/198 , A61K31/55 , A61K31/7048 , A61K45/06 , A61M25/04 , A61M2025/0086 , A61M2025/0087 , A61M2025/1047 , A61K2300/00
摘要： Various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue.
摘要翻译： 描述了各种递送装置以将药剂局部递送至肾神经。 输送装置位于肾动脉中并渗入肾动脉的壁中以将药剂递送至肾神经。 递送装置可以用于根据肾神经相对于肾动脉的纵向位置，径向位置和深度递送药剂。 另外，描述了各种方法去除神经，调节或以其他方式影响肾神经和其他神经组织。 而且，描述了各种试剂去神经，调节或以其他方式影响肾神经和其他神经组织。
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公开(公告)号：EP2968380A4
公开(公告)日：2017-03-22
申请号：EP14763047
申请日：2014-03-17
CPC分类号： A61K31/7048 , A61L29/16 , A61L31/16 , A61L2300/416
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公开(公告)号：EP2770992A1
公开(公告)日：2014-09-03
申请号：EP12844191.2
申请日：2012-10-25
申请人： Stein, Emily A. , Swanson, Christina D. , Evans, Michael A. , Venkateswara-Rao, Kondapavulur T.
发明人： Stein, Emily A. , Swanson, Christina D. , Evans, Michael A. , Venkateswara-Rao, Kondapavulur T.
IPC分类号： A61K31/401 , A61K31/405 , A61K31/704 , A61P9/02
CPC分类号： A61K31/7048 , A61K9/0012 , A61K31/401 , A61K31/405 , A61K31/4166 , A61K31/55 , A61K33/14 , A61K38/1787 , A61K45/06 , A61M25/0084 , A61M25/10 , A61M2025/0086 , A61M2025/1093 , A61K2300/00
摘要： Agents, methods, and devices for affecting nerve function are described. One embodiment of an agent includes a cardiac glycoside, an ACE inhibitor, and an NSAID. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One embodiment of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing.
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4.发明公开METHODS AND DEVICES FOR AFFECTING NERVE FUNCTION 审中-公开VERFAHREN UND VORRICHTUNGEN ZUR BEEINFLUSSUNG DER NERVENFUNKTION
公开(公告)号：EP2968380A2
公开(公告)日：2016-01-20
申请号：EP14763047.9
申请日：2014-03-17
IPC分类号： A61K31/704
CPC分类号： A61K31/7048 , A61L29/16 , A61L31/16 , A61L2300/416
摘要： Various methods and devices are described for affecting nerve function in the carotid body, renal nerves, and other nerves. Syringes, endovascular catheters, drug-eluting balloons, drug-eluting stents, and agent delivery patches are used to deliver a neuromodulatory agent to one or more nerves in order to treat a disease state.
摘要翻译： 描述了影响颈动脉体，肾神经和其他神经中的神经功能的各种方法和装置。 使用注射器，血管内导管，药物洗脱球囊，药物洗脱支架和药剂递送贴剂将神经调节剂递送至一个或多个神经以治疗疾病状态。
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5.发明公开AGENTS, METHODS, AND DEVICES FOR AFFECTING NERVE FUNCTION 审中-公开MITTEL，VERFAHREN，UND VORRICHTUNGEN ZUR BEEINFLUSSUNG DER NERVENFUNKTION
公开(公告)号：EP2770992A4
公开(公告)日：2015-12-30
申请号：EP12844191
申请日：2012-10-25
IPC分类号： A61K31/401 , A61K31/405 , A61K31/704 , A61P9/02
CPC分类号： A61K31/7048 , A61K9/0012 , A61K31/401 , A61K31/405 , A61K31/4166 , A61K31/55 , A61K33/14 , A61K38/1787 , A61K45/06 , A61M25/0084 , A61M25/10 , A61M2025/0086 , A61M2025/1093 , A61K2300/00
摘要： Agents, methods, and devices for affecting nerve function are described. One embodiment of an agent includes a cardiac glycoside, an ACE inhibitor, and an NSAID. The agent may be delivered locally in a site-specific manner to a targeted nerve or portion of a nerve. For example, the agent may be delivered locally to the renal nerves to impair their function and treat hypertension. One embodiment of a delivery device includes one or more needle housings supported by a balloon. A delivery needle is slidably disposed within a needle lumen of each needle housing.
摘要翻译： 描述了影响神经功能的药剂，方法和装置。 药剂的一个实施方案包括心脏糖苷，ACE抑制剂和NSAID。 药剂可以局部特异性方式局部递送至目标神经或神经的一部分。 例如，该药物可以局部递送至肾神经以损害其功能并治疗高血压。 输送装置的一个实施例包括由气囊支撑的一个或多个针壳体。 输送针可滑动地设置在每个针壳体的针内腔内。
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公开(公告)号：EP2528649A1
公开(公告)日：2012-12-05
申请号：EP11703963.6
申请日：2011-01-26
CPC分类号： A61M25/0084 , A61B5/0215 , A61B5/4094 , A61B5/4839 , A61B2017/22054 , A61B2017/22061 , A61B2017/22067 , A61B2090/378 , A61B2090/3784 , A61K31/198 , A61K31/55 , A61K31/7048 , A61K45/06 , A61M25/04 , A61M2025/0086 , A61M2025/0087 , A61M2025/1047 , A61K2300/00
摘要： Various delivery devices are described to deliver an agent locally to the renal nerves. The delivery devices are positioned in the renal artery and penetrate into the wall of the renal artery to deliver the agent to the renal nerves. The delivery devices may be used to deliver the agent according to longitudinal position, radial position, and depth of the renal nerves relative to the renal artery. In addition, various methods are described to denervate, modulate, or otherwise affect the renal nerves and other neural tissue. Also, various agents are described to denerve, modulate, or otherwise affect the renal nerves and other neural tissue.
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