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1.发明公开DELETION MUTANTS OF FLAGELLIN AND METHODS OF USE 审中-公开FLAGELLIN DELETIONSMUTANTEN UND DEREN VERWENDUNG
公开(公告)号：EP3115060A1
公开(公告)日：2017-01-11
申请号：EP16163252.6
申请日：2009-04-17
发明人： SONG, Langzhou , TUSSEY, Lynda G. , SHAW, Alan R. , BECKER, Robert S. , ZHANG, Yi , UMLAUF, Scott W. , TAYLOR, David N. , LIU, Ge , YEAGER, Mark D. , POWELL, Thomas J.
IPC分类号： A61K39/12 , A61K39/145 , A61K39/295 , A61K9/127 , A61K9/51 , C07K14/11 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/005 , C07K14/205 , C07K14/32 , C07K19/00 , C12N7/00
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one influenza antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.
摘要翻译： 包括Toll样受体5激动剂和至少一部分至少一种流感抗原的组合物可以用于刺激受试者中的免疫应答的方法，特别是受试者中的保护性免疫应答。 组合物可以与颗粒结合，并且在相对较低剂量的方法中使用，以提供对病毒感染的保护性免疫。
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公开(公告)号：EP2280991B1
公开(公告)日：2016-06-22
申请号：EP09732473.5
申请日：2009-04-17
发明人： SONG, Langzhou , TUSSEY, Lynda, G. , SHAW, Alan, R. , BECKER, Robert, S. , ZHANG, Yi , UMLAUF, Scott, W. , TAYLOR, David, N. , LIU, Ge , YEAGER, Mark, D. , POWELL, Thomas, J.
IPC分类号： C07K14/255 , A61K39/00 , A61K39/112 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K39/39 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/32 , C07K19/00 , C12N7/00
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one influenza antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.
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公开(公告)号：EP2280991A2
公开(公告)日：2011-02-09
申请号：EP09732473.5
申请日：2009-04-17
发明人： SONG, Langzhou , TUSSEY, Lynda, G. , SHAW, Alan, R. , BECKER, Robert, S. , ZHANG, Yi , UMLAUF, Scott, W. , TAYLOR, David, N. , LIU, Ge , YEAGER, Mark, D. , POWELL, Thomas, J.
IPC分类号： C07K14/255
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one influenza antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.
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