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公开(公告)号：EP2521563B1
公开(公告)日：2016-12-07
申请号：EP11732058.0
申请日：2011-01-05
CPC分类号： A61K39/145 , A61K38/164 , A61K39/12 , A61K39/385 , A61K2039/545 , A61K2039/55 , A61K2039/55516 , A61K2039/6068 , C07K2319/00 , C12N2760/16034
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2.发明授权
公开(公告)号：EP1991264B1
公开(公告)日：2015-01-07
申请号：EP07752324.9
申请日：2007-03-06
发明人： SONG, Langzhou , NAKAAR, Valerian , PRICE, Albert, E. , TUSSEY, Lynda, G. , HULEATT, James, W. , POWELL, Thomas, J. , EVANS, Robert, K.
IPC分类号： A61K39/02 , A61K39/145 , A61P31/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/02 , A61K39/0258 , A61K39/12 , A61K39/385 , A61K2039/543 , A61K2039/575 , A61K2039/6018 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , C07K14/005 , C07K14/11 , C07K14/195 , C07K14/255 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/16322 , C12N2760/16334 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/41 , Y02A50/412 , Y02A50/472 , Y02A50/474
摘要： Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the portion includes at least a portion of a globular head, includes at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.
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公开(公告)号：EP2521563A2
公开(公告)日：2012-11-14
申请号：EP11732058.0
申请日：2011-01-05
CPC分类号： A61K39/145 , A61K38/164 , A61K39/12 , A61K39/385 , A61K2039/545 , A61K2039/55 , A61K2039/55516 , A61K2039/6068 , C07K2319/00 , C12N2760/16034
摘要： Compositions that include a flagellin/antigen protein comprising at least a portion of at least one flagellin and at least a portion of at least one antigen and methods of administering these compositions to humans at least 49 years old. The compositions stimulate immune response to the antigen, in particular, a protective immune response to the antigen, in the human, such as an elderly human.
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公开(公告)号：EP2280991B1
公开(公告)日：2016-06-22
申请号：EP09732473.5
申请日：2009-04-17
发明人： SONG, Langzhou , TUSSEY, Lynda, G. , SHAW, Alan, R. , BECKER, Robert, S. , ZHANG, Yi , UMLAUF, Scott, W. , TAYLOR, David, N. , LIU, Ge , YEAGER, Mark, D. , POWELL, Thomas, J.
IPC分类号： C07K14/255 , A61K39/00 , A61K39/112 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K39/39 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/32 , C07K19/00 , C12N7/00
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one influenza antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.
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公开(公告)号：EP2280991A2
公开(公告)日：2011-02-09
申请号：EP09732473.5
申请日：2009-04-17
发明人： SONG, Langzhou , TUSSEY, Lynda, G. , SHAW, Alan, R. , BECKER, Robert, S. , ZHANG, Yi , UMLAUF, Scott, W. , TAYLOR, David, N. , LIU, Ge , YEAGER, Mark, D. , POWELL, Thomas, J.
IPC分类号： C07K14/255
CPC分类号： A61K39/39 , A61K9/127 , A61K9/5153 , A61K39/00 , A61K39/0005 , A61K39/0275 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/295 , A61K47/6937 , A61K2039/55516 , A61K2039/55544 , A61K2039/55555 , A61K2039/6031 , A61K2039/6068 , C07K14/005 , C07K14/11 , C07K14/205 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/32 , C07K19/00 , C07K2319/40 , C07K2319/75 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071 , C12N2760/16122 , C12N2760/16134 , C12N2760/16162 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/18522 , C12N2760/18534 , C12N2760/18571 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/394 , Y02A50/412
摘要： Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one influenza antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.
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6.发明公开
公开(公告)号：EP1991264A2
公开(公告)日：2008-11-19
申请号：EP07752324.9
申请日：2007-03-06
发明人： SONG, Langzhou , NAKAAR, Valerian , PRICE, Albert, E. , TUSSEY, Lynda, G. , HULEATT, James, W. , POWELL, Thomas, J. , EVANS, Robert, K.
IPC分类号： A61K39/02 , A61K39/145 , A61P31/00
CPC分类号： A61K39/145 , A61K39/00 , A61K39/02 , A61K39/0258 , A61K39/12 , A61K39/385 , A61K2039/543 , A61K2039/575 , A61K2039/6018 , A61K2039/6037 , A61K2039/6068 , A61K2039/6075 , C07K14/005 , C07K14/11 , C07K14/195 , C07K14/255 , C07K2319/00 , C12N7/00 , C12N15/62 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171 , C12N2760/16222 , C12N2760/16234 , C12N2760/16271 , C12N2760/16322 , C12N2760/16334 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/41 , Y02A50/412 , Y02A50/472 , Y02A50/474
摘要： Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the portion includes at least a portion of a globular head, includes at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.
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