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    COMPOSITIONS THAT INCLUDE HEMAGGLUTININ, METHODS OF MAKING AND METHODS OF USE THEREOF
    6.
    发明公开
    COMPOSITIONS THAT INCLUDE HEMAGGLUTININ, METHODS OF MAKING AND METHODS OF USE THEREOF 审中-公开
    含HA，方法组成用于生产和及其方法使用

    公开(公告)号：EP3011969A1

    公开(公告)日：2016-04-27

    申请号：EP15180367.3

    申请日：2007-03-06

    申请人： Vaxinnate Corporation

    发明人： SONG, Langzhou ,  NAKAAR, Valerian ,  PRICE, Albert E ,  TUSSEY, Lynda G ,  HULEATT, James W. ,  POWELL, Thomas ,  EVANS, Robert

    IPC分类号： A61K39/02 ,  A61K39/145 ,  A61P31/00

    CPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/02 ,  A61K39/0258 ,  A61K39/12 ,  A61K39/385 ,  A61K2039/543 ,  A61K2039/575 ,  A61K2039/6018 ,  A61K2039/6037 ,  A61K2039/6068 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/11 ,  C07K14/195 ,  C07K14/255 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/62 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16271 ,  C12N2760/16322 ,  C12N2760/16334 ,  C12N2770/24122 ,  C12N2770/24134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/472 ,  Y02A50/474

    摘要： Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the portion includes at least a portion of a globular head, includes at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.

    摘要翻译： 制备和组合物的方法做了刺激受试者中的保护性免疫应答包括来自天然存在的病毒血凝素蛋白质的一部分，worin所述部分包括至少一个球状头部的一部分，包括至少至少一个次要的一部分 结构也使球状头部基本上保留其三级结构和缺少膜融合结构域，跨膜结构域和胞质结构域。 组合物包含鞭毛蛋白组分或Toll样受体激动剂组分所做的是至少一个鞭毛蛋白或Toll样受体激动剂的一部分，worin鞭毛蛋白组分或Toll样受体激动剂组分包括至少一个半胱氨酸残基，并且其中所述 鞭毛蛋白组分或Toll样受体激动剂组分激活Toll样受体5或Toll样受体。 组合物包含鞭毛蛋白成分确实被至少一个鞭毛蛋白的部分，所述鞭毛蛋白组分worin至少一个赖氨酸已经substituiertem与至少一种精氨酸，丝氨酸和组氨酸，由此鞭毛部件的激活Toll样受体5的组合物可以 进一步包括抗原检查，以流感病毒抗原，黄病毒抗原，病原体相关抗原，细菌荚膜抗原和载体蛋白。 所述组合物用于刺激免疫反应和在受试者中产生保护性免疫应答。