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公开(公告)号：EP3860712A1
公开(公告)日：2021-08-11
申请号：EP19848828.0
申请日：2019-10-04
发明人： BLIGH, Cavan McKeon , BRODNEY, Michael Aaron , ECCLES, Mary Elizabeth , GAGNON, Kevin James , HOOD, Sarah Carol , HUSSEY, Joshua Kennedy , LOOKER, Adam , MAXWELL, John Patrick , MEDEK, Ales , NAVAMAL, Mettachit , RODAY, Setu , ROEPER, Stefanie , SAWANT, Rupa , SHI, Yi , TANG, Qing , WALDO, Michael , BANDARAGE, Upul Keerthi , BOUCHER, Diane M. , BOYD, Michael John , DAMAGNEZ, Veronique , DEWEY FANNING, Lev Tyler , FIMOGNARI Jr., Robert Francis , GARCIA BARRANTES, Pedro M. , GIROUX, Simon , GREY Jr., Ronald Lee , HALL, Amy Beth , HURLEY, Dennis James , JOHNSON, Jr., Mac Arthur , JONES, Peter , KESAVAN, Sarathy , NUHANT, Philippe Marcel , SWETT, Rebecca Jane , TAPLEY, Timothy Lewis , THOMSON, Stephen A. , XU, Jinwang , MAXWELL, Brad D. , COTTRELL, Kevin Michael
IPC分类号： A61P1/16 , A61P11/00 , C07D471/14 , C07D487/04 , C07D487/14 , C07D519/00 , A61K31/5377 , A61K31/4985 , A61K31/496 , A61K31/4162 , A61K31/4439 , A61K31/427 , A61K31/4178 , A61K31/4196 , A61K31/437
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公开(公告)号：EP4126877A1
公开(公告)日：2023-02-08
申请号：EP21722013.6
申请日：2021-04-02
发明人： GIROUX, Simon , BOYD, Michael John , FIMOGNARI, JR., Robert Francis , ZAKY, Mariam , GREY, JR., Ronald Lee , XU, Jinwang , KESAVAN, Sarathy , NUHANT, Philippe Marcel , GARCIA BARRANTES, Pedro Manuel , JONES, Peter , BRODNEY, Michael Aaron , BOUCHER, Diane Marie , FANNING, Lev T., D. , HALL, Amy B. , HURLEY, Dennis James , JOHNSON, JR., Mac Arthur , MAXWELL, John Patrick , SWETT, Rebecca Jane , TAPLEY, Timothy Lewis , THOMSON, Stephen A. , DAMAGNEZ, Veronique , COTTRELL, Kevin Michael
IPC分类号： C07D487/04 , C07D471/14 , A61K31/4162 , A61K31/437 , A61K31/407 , A61P1/00 , A61P1/14 , A61P1/16 , A61P11/00 , A61P11/08 , A61P11/10 , A61P17/00 , A61P31/00 , A61P31/02 , A61P35/00
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公开(公告)号：EP3412668A2
公开(公告)日：2018-12-12
申请号：EP18180366.9
申请日：2014-09-25
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P1/00 , A61P35/00 , A61K31/4439
CPC分类号： C07D471/04
摘要： The present invention relates to a compound having the formula:
or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising said compound or the salt thereof
for use in the treatment of a cancer that is associated with dysregulation of the PI3K signaling pathway.-
公开(公告)号：EP3969440A1
公开(公告)日：2022-03-23
申请号：EP20780387.5
申请日：2020-05-14
发明人： BANDARAGE, Upul Keerthi , BLIGH, Cavan McKeon , BOUCHER, Diane , BOYD, Michael John , BRODNEY, Michael Aaron , CLARK, Michael Philip , DAMAGNEZ, Veronique , FANNING, Lev Tyler Dewey , FIMOGNARI, Robert Francis , FLEMING, Gabrielle Simone , GAGNON, Kevin James , GARCIA BARRANTES, Pedro Manuel , GIACOMETTI, Robert Daniel , GIROUX, Simon , GREY JR., Ronald Lee , GUIDO, Samantha , HALL, Amy Beth , HOOD, Sarah Carol , HURLEY, Dennis James , JOHNSON, JR., Mac Arthur , JONES, Peter , KESAVAN, Sarathy , LAI, Mei-Hsiu , LIU, Siying , LOOKER, Adam , MAXWELL, Brad , MAXWELL, John Patrick , MEDEK, Ales , NUHANT, Philippe Marcel , OVERHOFF, Kirk Alan , RODAY, Setu , ROEPER, Stefanie , RONKIN, Steven M. , SAWANT, Rupa , SHI, Yi , SHRESTHA, Muna , SPOSATO, Marisa , STAVROPOULOS, Kathy , SWETT, Rebecca Jane , TANG, Qing , TAPLEY, Timothy Lewis , THOMSON, Stephen , XU, Jinwang , ZAKY, Mariam , COTTRELL, Kevin Michael
IPC分类号： C07D231/56 , C07D487/04 , C07D498/18 , C07D513/04 , A61P11/00 , A61P1/16 , A61K31/4162 , A61K31/429
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公开(公告)号：EP3412668B1
公开(公告)日：2020-02-05
申请号：EP18180366.9
申请日：2014-09-25
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P1/00 , A61P35/00 , A61K31/4439
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6.发明公开
公开(公告)号：EP4132908A1
公开(公告)日：2023-02-15
申请号：EP21725849.0
申请日：2021-04-02
发明人： GIROUX, Simon , CLARK, Michael Philip , BRODNEY, Michael Aaron , NUHANT, Philippe Marcel , ALLEN, Emily Elizabeth , FIMOGNARI, JR., Robert Francis , ZAKY, Mariam , BOYD, Michael John , DEININGER, David D. , ZHANG, Hu , DENG, Hongbo , COLLIER, Philip Noel , MAXWELL, Brad , WAAL, Nathan D. , RONKIN, Steven M. , WANG, Jian , TANG, Qing , FLEMING, Gabrielle Simone , JONES, Peter , BOUCHER, Diane Marie , FANNING, Lev T.D. , HALL, Amy B. , HURLEY, Dennis James , JOHNSON, JR., Mac Arthur , MAXWELL, John Patrick , SWETT, Rebecca Jane , TAPLEY, Timothy Lewis , THOMSON, Stephen A. , DAMAGNEZ, Veronique , COTTRELL, Kevin Michael , BANDARAGE, Upul Keerthi
IPC分类号： C07D209/08 , C07D209/18 , C07D209/30 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D471/04 , C07D493/08 , A61K31/404 , A61K31/35 , A61K31/381 , A61P1/00 , A61P1/14 , A61P1/16
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公开(公告)号：EP4126817A1
公开(公告)日：2023-02-08
申请号：EP21732608.1
申请日：2021-04-02
发明人： GIROUX, Simon , CLARK, Michael Philip , TANG, Qing , NUHANT, Philippe Marcel , JONES, Peter , MESSERSMITH, David , BANDARAGE, Upul Keerthi , COTTRELL, Kevin Michael , BRODNEY, Michael Aaron , FLEMING, Gabrielle Simone , WANG, Jian , XU, Jinwang , DANIEL, Kevin Brett , BOYD, Michael John , MORRIS, Mark A. , WAAL, Nathan D. , COLLIER, Philip Noel , KESAVAN, Sarathy , RONKIN, Steven M. , DENG, Hongbo , BOUCHER, Diane Marie , FANNING, Lev T.D. , HALL, Amy B. , HURLEY, Dennis James , JOHNSON, JR., Mac Arthur , MAXWELL, John Patrick , SWETT, Rebecca Jane , TAPLEY, Timothy Lewis , THOMSON, Stephen A. , DAMAGNEZ, Veronique
IPC分类号： C07D209/10 , A61P11/00 , A61K31/404 , A61P29/00 , A61P43/00 , C07D209/12 , C07D209/14 , C07D209/22 , C07D209/24 , C07D209/42 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04
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公开(公告)号：EP3049415B1
公开(公告)日：2018-07-04
申请号：EP14789651.8
申请日：2014-09-25
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P1/00
CPC分类号： C07D471/04
摘要： The present invention relates to a compound useful as a selective inhibitor of PI3Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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