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公开(公告)号：EP1592686A1
公开(公告)日：2005-11-09
申请号：EP04775744.8
申请日：2004-01-29
发明人： CHARIFSON, Paul, S. , DEININGER, David, D. , GRILLOT, Anne-Laure , LIAO, Yusheng , RONKIN, Steven, M. , STAMOS, Dean , PEROLA, Emauele , WANG, Tiansheng , LETIRAN, Arnaud , DRUMM, Joseph
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D403/10 , C07D491/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/4184 , A61P31/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. Formula (I).
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公开(公告)号：EP1948635A1
公开(公告)日：2008-07-30
申请号：EP06827594.0
申请日：2006-11-06
发明人： CHARIFSON, Paul , DEININGER, David , DRUMM, Joseph , GRILLOT, Anne-Laure , LeTIRAN, Arnaud , LIAO, Yusheng , PEROLA, Emanuele , RONKIN, Steven , STAMOS, Dean , WANG, Tiansheng
IPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , A61K31/4184 , A61P31/04
CPC分类号： C07D403/04 , C07D401/04 , C07D403/14
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals.
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3.发明公开2-UREIDO-6-HETEROARYL-3H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND RELATED COMPOUNDS AS GYRASE AND/OR TOPOISOMERASE IV INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS 有权2脲基 - 6 - 杂芳基-3H-苯并咪唑-4-羧酸衍生物和相关化合物ALS促旋酶和/或拓扑异构酶IV的抑制剂用于细菌感染的治疗
公开(公告)号：EP1511482A1
公开(公告)日：2005-03-09
申请号：EP03739082.0
申请日：2003-06-11
发明人： CHARIFSON, Paul , DEININGER, David, D. , DRUMM, Joseph , GRILLOT, Anne-Laure , LIAO, Yusheng , OLIVER-SHAFFER, Patricia , STAMOS, Dean
IPC分类号： A61K31/4439 , A61K31/506 , A61K31/444 , C07D401/04 , C07D403/04 , C07D401/14 , C07C275/64
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07C275/06 , C07D401/14 , C07D403/04 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.
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公开(公告)号：EP1341769A2
公开(公告)日：2003-09-10
申请号：EP01994269.7
申请日：2001-12-12
发明人： GRILLOT, Anne-Laure , CHARIFSON, Paul , STAMOS, Dean , LIAO, Yusheng , BADIA, Michael , TRUDEAU, Martin
IPC分类号： C07D235/30 , C07D263/58 , C07D403/04 , C07D413/04 , A61K31/00 , A61K31/4184 , A61K31/4439 , A61K31/506 , A61K31/437 , A61K31/4709 , A61K31/55 , A61K31/5377 , A61K31/423 , A61K45/06 , A61P31/04
CPC分类号： C07D403/12 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D235/30 , C07D249/08 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07F9/65583 , C07F9/6561 , Y02A50/393 , Y02A50/473 , A61K2300/00
摘要： The present invention relates to compounds of the formula I or a pharmaceutically acceptable derivative thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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公开(公告)号：EP2350045A1
公开(公告)日：2011-08-03
申请号：EP09744003.6
申请日：2009-10-20
发明人： LAUFFER, David , LI, Pan , MCGINTY, Kira , RONKIN, Steven , TANG, Qing , GRILLOT, Anne-Laure , WAAL, Nathan
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/06
CPC分类号： C07D401/14 , C07D401/04 , C07D405/14 , C07D409/14 , C07D451/06
摘要： The present invention relates to compounds of formula (I) useful in the inhibition of c- Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.
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公开(公告)号：EP1592686B1
公开(公告)日：2009-07-08
申请号：EP04775744.8
申请日：2004-01-29
发明人： CHARIFSON, Paul, S. , DEININGER, David, D. , GRILLOT, Anne-Laure , LIAO, Yusheng , RONKIN, Steven, M. , STAMOS, Dean , PEROLA, Emauele , WANG, Tiansheng , LE TIRAN, Arnaud , DRUMM, Joseph
IPC分类号： C07D403/14 , C07D401/14 , C07D405/14 , C07D403/10 , C07D491/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/4184 , A61P31/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. Formula (I).
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公开(公告)号：EP1064298B1
公开(公告)日：2008-10-08
申请号：EP99912662.6
申请日：1999-03-19
发明人： WANNAMAKER, Marion, W. , BEMIS, Guy, W. , CHARIFSON, Paul, S. , LAUFFER, David, J. , MULLICAN, Michael, D. , MURCKO, Mark, A. , WILSON, Keith, P. , JANETKA, James, W. , DAVIES, Robert, J. , GRILLOT, Anne-Laure , SHI, Zhan , FORSTER, Cornelia, J.
CPC分类号： C07K5/0202 , A61K38/00 , C07D401/12 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/475
摘要： The present invention relates to novel classes of compounds which are caspase inhibitors, in particular interleukin-1² converting enzyme ("ICE") inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting caspase activity and consequently, may be advantageously used as agents against interleukin-1- ("IL-1"), apoptosis-, interferon-³ inducing factor-(IGIF), or interferon-³-("IFN-³") mediated diseases, including inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, and degenerative diseases. This invention also relates to methods for inhibiting caspase activity and decreasing IGIF production and IFN-³ production and methods for treating interleukin-1, apoptosis-, and interferon-³ mediated diseases using the compounds and compositions of this invention. This invention also relates to methods of preparing the compounds of this invention.
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公开(公告)号：EP1341769B1
公开(公告)日：2007-10-17
申请号：EP01994269.7
申请日：2001-12-12
发明人： GRILLOT, Anne-Laure , CHARIFSON, Paul , STAMOS, Dean , LIAO, Yusheng , BADIA, Michael , TRUDEAU, Martin
IPC分类号： C07D235/30 , C07D263/58 , C07D403/04 , C07D413/04 , A61K31/00 , A61K31/4184 , A61K31/4439 , A61K31/506 , A61K31/437 , A61K31/4709 , A61K31/55 , A61K31/5377 , A61K31/423 , A61K45/06 , A61P31/04
CPC分类号： C07D403/12 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D235/30 , C07D249/08 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07F9/65583 , C07F9/6561 , Y02A50/393 , Y02A50/473 , A61K2300/00
摘要： The present invention relates to compounds of the formula I or a pharmaceutically acceptable derivative thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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9.发明授权2-UREIDO-6-HETEROARYL-3H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID DERIVATIVES AND RELATED COMPOUNDS AS GYRASE AND/OR TOPOISOMERASE IV INHIBITORS FOR THE TREATMENT OF BACTERIAL INFECTIONS 有权2脲基 - 6 - 杂芳基-3H-苯并咪唑-4-羧酸衍生物和相关化合物ALS促旋酶和/或拓扑异构酶IV的抑制剂用于细菌感染的治疗
公开(公告)号：EP1511482B1
公开(公告)日：2006-11-15
申请号：EP03739082.0
申请日：2003-06-11
发明人： CHARIFSON, Paul , DEININGER, David, D. , DRUMM, Joseph , GRILLOT, Anne-Laure , LIAO, Yusheng , OLIVER-SHAFFER, Patricia , STAMOS, Dean
IPC分类号： A61K31/4439 , A61K31/506 , A61K31/444 , C07D401/04 , C07D403/04 , C07D401/14 , C07C275/64
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/444 , A61K31/506 , A61K45/06 , C07C275/06 , C07D401/14 , C07D403/04 , Y02A50/473 , Y02A50/478 , A61K2300/00
摘要： The present invention relates to compounds which inhibit bacterial gyrase and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to a method for preparing these compounds.
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10.发明公开INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES 有权c-Jun N-末端激酶（JNK）AND OTHER蛋白抑制剂KINASES-
公开(公告)号：EP1218369A1
公开(公告)日：2002-07-03
申请号：EP00957485.6
申请日：2000-08-11
发明人： GREEN, Jeremy , BEMIS, Guy , GRILLOT, Anne-Laure , LEDEBOER, Mark , SALITURO, Francis , HARRINGTON, Edmund , GAO, Huai , BAKER, Christopher , CAO, Jingrong , HALE, Michael
IPC分类号： C07D401/04 , C07D405/04 , C07D403/04 , C07D413/04 , A61K31/341 , A61K31/4155 , A61K31/4192 , A61K31/42
CPC分类号： C07D413/04 , A61K31/341 , A61K31/4155 , A61K31/4192 , A61K31/42 , C07D413/14
摘要： The present invention provides compounds of formula (I) where R1 is H, CONH¿2?, T(n)-R, or T(n)-Ar?2¿, n may be zero or one, and G, XYZ, and Q are as described below. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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