公开(公告)号：EP2739623B1

公开(公告)日：2017-01-11

申请号：EP12746215.8

申请日：2012-08-01

申请人： Vertex Pharmaceuticals Incorporated

发明人： CHARIFSON, Paul, S. ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  BOYD, Michael, J. ,  DAVIES, Ioana ,  DENG, Hongbo ,  DUFFY, John, P. ,  FARMER, Luc, J. ,  GAO, Huai ,  GU, Wenxin ,  KENNEDY, Joseph, M. ,  LEDFORD, Brian ,  LEDEBOER, Mark, W. ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng

IPC分类号： C07D471/04 ,  A61K31/506 ,  A61K31/444 ,  A61P31/16

CPC分类号： C07D471/04 ,  A61K31/215 ,  A61K31/351 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K45/06 ,  C07F9/6561

摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A compound is represented by Structural Formula ( I ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( I ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

摘要翻译： 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（I）的值如本文所述。 化合物由结构式（I）或其药学上可接受的盐表示，其中结构式（I）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。

公开(公告)号：EP1931674B1

公开(公告)日：2012-12-12

申请号：EP06815526.6

申请日：2006-09-28

申请人： Vertex Pharmaceuticals Incorporated

发明人： SALITURO, Francesco ,  FARMER, Luc ,  WANG, Tiansheng ,  WANG, Jian ,  BETHIEL, Randy ,  WANNAMAKER, Marion ,  MARTINEZ-BOTELLA, Gabriel ,  DUFFY, John ,  ARONOV, Alexander ,  LAUFFER, David ,  PIERCE, Albert

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/495 ,  A61P29/00 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D487/04

公开(公告)号：EP2283013A1

公开(公告)日：2011-02-16

申请号：EP09733572.3

申请日：2009-04-14

申请人： Vertex Pharmaceuticals Incorporated

发明人： WANG, Tiansheng ,  ARONOV, Alexander ,  CORNEBISE, Mark ,  MALTAIS, Francois ,  LEDOBOER, Mark ,  LE TIRAN, Arnaud ,  MARONE, Valerie ,  MESSERSMITH, David ,  COTTRELL, Kevin ,  COME, Jon, H. ,  BOTELA, Gabriel, Martinez

IPC分类号： C07D417/04 ,  C07D513/04 ,  A61K31/428 ,  A61K31/4365 ,  A61P37/00

CPC分类号： C07D513/04 ,  C07D417/04

摘要： The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K ggr;. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

摘要翻译： 本发明涉及用作PI3K抑制剂的化合物，特别是PI3K ggr。的抑制剂。 本发明还提供了包含所述化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病，病症或障碍的方法。

公开(公告)号：EP1592686B1

公开(公告)日：2009-07-08

申请号：EP04775744.8

申请日：2004-01-29

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： CHARIFSON, Paul, S. ,  DEININGER, David, D. ,  GRILLOT, Anne-Laure ,  LIAO, Yusheng ,  RONKIN, Steven, M. ,  STAMOS, Dean ,  PEROLA, Emauele ,  WANG, Tiansheng ,  LE TIRAN, Arnaud ,  DRUMM, Joseph

IPC分类号： C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D403/10 ,  C07D491/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4184 ,  A61P31/04

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. Formula (I).

公开(公告)号：EP2061787A2

公开(公告)日：2009-05-27

申请号：EP07811661.3

申请日：2007-09-04

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： WANG, Tiansheng ,  GREEN, Jeremy ,  CORNEBISE, Mark ,  LEDFORD, Brian ,  PARSONS, Jonathan ,  TANNER, Adam ,  WESTCOTT, James

IPC分类号： C07D417/04 ,  A61K31/427 ,  A61P37/00 ,  A61P35/00

CPC分类号： C07D417/04

摘要： The present invention relates to compounds of formula (I) useful as inhibitors of P13K particularly of P13Kγ. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP4043460A1

公开(公告)日：2022-08-17

申请号：EP22161962.0

申请日：2019-04-23

申请人： Merck Patent GmbH ,  Vertex Pharmaceuticals Incorporated

发明人： KULKARNI, Shashank ,  YU, Henry ,  CLARK, Michael ,  BEMIS, Guy ,  BOYD, Michael ,  CHANDUPATLA, Kishan ,  COLLIER, Philip ,  DENG, Hongbo ,  DONG, Huijun ,  DORSCH, Warren ,  HOOVER, Russell, R. ,  JOHNSON, Mac, Arthur, JR. ,  PENNEY, Marina ,  RONKIN, Steven ,  TAKEMOTO, Darin ,  TANG, Qing ,  WAAL, Nathan, D. ,  WANG, Tiansheng ,  LAUFFER, David J. ,  LI, Pan

IPC分类号： C07D413/14 ,  C07D403/04 ,  C07D409/14 ,  C07D413/04 ,  A61K31/553 ,  A61P35/00

摘要： The present invention provides compounds of Formula (I'), or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g. cancer).

公开(公告)号：EP2442809B1

公开(公告)日：2016-08-31

申请号：EP10726760.1

申请日：2010-06-17

申请人： Vertex Pharmaceuticals Incorporated

发明人： CHARIFSON, Paul ,  CLARK, Michael, P. ,  BANDARAGE, Upul, K. ,  BETHIEL, Randy, S. ,  COURT, John, J. ,  DENG, Hongbo ,  DRUTU, Ioana ,  DUFFY, John, P. ,  FARMER, Luc ,  GAO, Huai ,  GU, Wenxin ,  JACOBS, Dylan, H. ,  KENNEDY, Joseph, M. ,  LEDEBOER, Mark, W. ,  LEDFORD, Brian ,  MALTAIS, Francois ,  PEROLA, Emanuele ,  WANG, Tiansheng ,  WANNAMAKER, M., Woods ,  BYRN, Randal ,  ZHOU, Yi ,  LIN, Chao ,  JIANG, Min ,  GERMANN, Ursula, A. ,  JONES, Steven ,  SALITURO, Francesco G. ,  KWONG, Ann Dak-Yee

IPC分类号： A61K31/506 ,  A61P31/16

CPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D239/30 ,  C07D401/04 ,  C07D401/10 ,  C07D471/04

摘要： Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula ( I ): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A compound is represented by Structural Formula ( IA ) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula ( IA ) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

摘要翻译： 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（IA）的值如本文所述。 化合物由结构式（IA）或其药学上可接受的盐表示，其中结构式（IA）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。

公开(公告)号：EP2144878A2

公开(公告)日：2010-01-20

申请号：EP08744172.1

申请日：2008-03-21

申请人： Vertex Pharmaceuticals Incorporated

发明人： WANNAMAKER, Marion ,  SALITURO, Francesco ,  PIERCE, Albert ,  ARONOV, Alexander ,  MARTINEZ-BOTELLA, Gabriel ,  WANG, Jian ,  FARMER, Luc ,  LEDEBOER, Mark ,  WANG, Tiansheng ,  BETHIEL, Randy ,  LEDFORD, Brian ,  PORTER, Emilie

IPC分类号： C07D213/74

CPC分类号： C07D401/14 ,  C07D213/74 ,  C07D239/42 ,  C07D401/04 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

公开(公告)号：EP1592686A1

公开(公告)日：2005-11-09

申请号：EP04775744.8

申请日：2004-01-29

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： CHARIFSON, Paul, S. ,  DEININGER, David, D. ,  GRILLOT, Anne-Laure ,  LIAO, Yusheng ,  RONKIN, Steven, M. ,  STAMOS, Dean ,  PEROLA, Emauele ,  WANG, Tiansheng ,  LETIRAN, Arnaud ,  DRUMM, Joseph

IPC分类号： C07D403/14 ,  C07D401/14 ,  C07D405/14 ,  C07D403/10 ,  C07D491/04 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4184 ,  A61P31/04

CPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04

摘要： The present invention relates to compounds which inhibit bacterial gyrase and/or Topo IV and pharmaceutically acceptable compositions comprising said compounds. These compounds, and compositions thereof, are useful in treating bacterial infection. Accordingly, the present invention also relates to methods for treating bacterial infections in mammals. Formula (I).

公开(公告)号：EP1581488A1

公开(公告)日：2005-10-05

申请号：EP03813772.5

申请日：2003-12-19

申请人： VERTEX PHARMACEUTICALS INCORPORATED

发明人： BANDARAGE, Upul ,  COME, Jon, H. ,  PEROLA, Emanuele ,  BHISETTI, Govinda, Rao ,  SAUNDERS, Jeffrey, O. ,  WANG, Tiansheng

IPC分类号： C07D207/12 ,  C07D261/04 ,  C07D205/04 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07C323/65 ,  A61K31/40 ,  A61P35/00

CPC分类号： C07D401/12 ,  C07C323/65 ,  C07C2601/08 ,  C07D205/04 ,  C07D207/12 ,  C07D261/04 ,  C07D403/12 ,  C07D413/12

摘要： The present invention relates to compounds that inhibit TACE, compositions thereof, and methods of using those compounds and compositions for treating diseases.

摘要翻译： 本发明涉及抑制TACE的化合物，其组合物以及使用这些化合物和组合物治疗疾病的方法。