公开(公告)号：EP1161523A4

公开(公告)日：2003-04-02

申请号：EP00916410

申请日：2000-03-17

申请人： WELLSTAT BIOLOGICS CORP ,  US GOV HEALTH & HUMAN SERV

发明人： MAJOR EUGENE O ,  BARKER JEFFERY L ,  MARIC DRAGAN ,  RABIN HARVEY ,  SANDLER ABBY

IPC分类号： G01N33/50 ,  A61K35/12 ,  A61K35/30 ,  A61P25/00 ,  A61P25/16 ,  C12N5/0797 ,  C12N5/10 ,  C12Q1/04 ,  G01N33/15 ,  G01N33/53 ,  C12N5/06 ,  C12N5/08

CPC分类号： C12N5/0623 ,  A61K35/12 ,  C12N7/00 ,  C12N2510/00 ,  C12N2510/04 ,  C12N2710/22051

摘要： The present invention generally relates to stem cells, including progenitor and precursor cells, which are preferably immortalized, and have been derived from the central nervous system (CNS); methods for treating a host by implanting the disclosed cells, and genetically altered forms of the disclosed cells in the host, and methods for making same.

公开(公告)号：EP1390046A4

公开(公告)日：2005-04-20

申请号：EP00922256

申请日：2000-04-17

申请人： WELLSTAT BIOLOGICS CORP

发明人： ROBERTS MICHAEL S ,  LORENCE ROBERT M ,  GROENE WILLIAM S ,  RABIN HARVEY ,  VON BORSTEL REID W

IPC分类号： A61K45/00 ,  A61K31/282 ,  A61K31/573 ,  A61K35/76 ,  A61K38/00 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P43/00 ,  C07J5/00 ,  C07K16/24 ,  C12N7/02 ,  G01N33/50 ,  A61K31/70 ,  A01N63/00 ,  A01N65/00

CPC分类号： G01N33/5011 ,  A61K31/4164 ,  A61K35/76 ,  A61K38/191 ,  A61K38/2013 ,  A61K38/21 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/241 ,  C12N7/00 ,  C12N2760/18132 ,  C12N2760/18151 ,  A61K2300/00

摘要： The subject invention relates to viruses that are able to replicate and thereby kill neoplastic cells with a deficiency in the IFN-mediated antiviral response, and their use in treating neoplastic disease including cancer and large tumors. RNA and DNA viruses are useful in this regard. The invention also relates to methods for the selection, design, purification and use of such viruses for cancer therapy.