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公开(公告)号：EP4385512A1
公开(公告)日：2024-06-19
申请号：EP24161602.8
申请日：2019-07-18
IPC分类号： A61K31/5415 , A61K45/06 , A61P25/28
CPC分类号： A61K31/5415 , A61K45/06 , A61P25/28
摘要： The invention provides novel dosing regimens for Leuco-Methylthioninium (LMT) compounds which maximise the proportion of subjects in which the MT concentration will exceed concentrations in which therapeutic efficacy in relation to treatment of neurodegenerative disorders such as Alzheimer's disease and rontotemporal dementias can be achieved, while maintaining a desirable clinical profile. Also provided are LMT-containing dosage units and other compositions.
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公开(公告)号：EP4146224A1
公开(公告)日：2023-03-15
申请号：EP21723700.7
申请日：2021-04-30
IPC分类号： A61K31/5415 , A61K31/4706 , A61K45/06 , A61P31/14
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公开(公告)号：EP2167095B1
公开(公告)日：2019-05-29
申请号：EP08762390.6
申请日：2008-06-17
发明人： WISCHIK, Claude Michel , HARBARAN, Dominic Venay , RIEDEL, Gernot , DEIANA, Serena , GOATMAN, Elizabeth Anne , WISCHIK, Damon Jude , MURRAY, Alison Dorothy , STAFF, Roger Todd
IPC分类号： A61K31/5415 , A61P25/28
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公开(公告)号：EP3112358A3
公开(公告)日：2017-01-11
申请号：EP16177114.2
申请日：2009-12-10
发明人： CLUNAS, Scott , STOREY, John Mervyn David , RICKARD, Janet Elizabeth , HORSLEY, David , HARRINGTON, Charles Robert , WISCHIK, Claude Michel
IPC分类号： C07D311/82 , C07D335/12 , C07D241/46 , C07D265/38 , C07D311/90 , C07D493/16 , A61K31/352 , A61K31/382 , A61K31/498 , A61K31/538 , A61P25/28
CPC分类号： C07D311/82 , A61K9/0053 , A61K31/352 , A61K31/382 , A61K31/4025 , A61K31/4545 , A61K31/4745 , A61K31/498 , A61K31/5377 , A61K31/538 , A61K45/06 , A61K49/00 , C07D241/46 , C07D265/38 , C07D311/84 , C07D311/90 , C07D335/12 , C07D335/14 , C07D335/20 , C07D491/16 , C07D491/22 , C07D493/16 , C09B11/24 , C09B11/28 , C09B17/00 , C09B19/00 , C09B21/00 , C09B57/00 , G01N33/6896 , G01N2800/7047
摘要： This invention pertains generally to processes, uses, methods and materials utilising xanthylium compounds of formula (II) as further defined herein. These compounds are useful as drugs, for example, in the treatment of tauopathies, such as Alzheimer's disease.
摘要翻译： 本发明一般涉及使用本文进一步定义的式（II）的呫吨化合物的方法，用途，方法和材料。 这些化合物可用作药物，例如治疗tau蛋白病，例如阿尔茨海默氏病。
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公开(公告)号：EP4223297A3
公开(公告)日：2023-11-15
申请号：EP23165202.5
申请日：2017-07-25
发明人： WISCHIK, Claude Michel , SCHELTER, Björn Olaf , WISCHIK, Damon Jude , STOREY, John Mervyn David
IPC分类号： A61K31/5415 , A61P25/28 , A61P9/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/02 , A61P3/02 , A61P25/14 , A61P25/16 , A61P43/00
摘要： The invention provides novel regimens for treatment of neurodegenerative disorders utilising methylthioninium (MT)-containing compounds. The regimens are based on novel findings in relation to the dosage of MT compounds, and their interaction with symptomatic treatments based on modulation of acetylcholinesterase levels.
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公开(公告)号：EP3993805A1
公开(公告)日：2022-05-11
申请号：EP20737381.2
申请日：2020-06-29
IPC分类号： A61K31/5415 , A61K45/06 , A61P25/28
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7.发明公开METHODS OF CHEMICAL SYNTHESIS AND PURIFICATION OF DIAMINOPHENOTHIAZINIUM COMPOUNDS INCLUDING METHYLTHIONINIUM CHLORIDE (MTC) 有权化学合成及DIAMINOPHENOTHIAZINIUMVERBINDUNGEN包括亚甲蓝纯化方法（MTC）
公开(公告)号：EP1799662A2
公开(公告)日：2007-06-27
申请号：EP05783989.6
申请日：2005-09-21
发明人： STOREY, John Mervyn David , SINCLAIR, James Peter , MARSHALL, Colin , TAN, Han Wan , WISCHIK, Claude Michel
IPC分类号： C07D279/18 , A61K31/54 , A61P35/00 , A61P25/28
CPC分类号： A61K31/5415 , A61K9/0019 , A61K49/006 , C07D279/18 , C09B19/02 , G01N33/52 , Y02A50/393
摘要： This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.
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公开(公告)号：EP4457838A1
公开(公告)日：2024-11-06
申请号：EP22839163.7
申请日：2022-12-13
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公开(公告)号：EP4146223A1
公开(公告)日：2023-03-15
申请号：EP21723699.1
申请日：2021-04-30
IPC分类号： A61K31/5415 , A61K45/06 , A61P31/14
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公开(公告)号：EP3487505A1
公开(公告)日：2019-05-29
申请号：EP17743330.7
申请日：2017-07-25
发明人： WISCHIK, Claude Michel , SCHELTER, Björn Olaf , WISCHIK, Damon Jude , STOREY, John Mervyn David
IPC分类号： A61K31/5415 , A61P25/28
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