利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

24 条记录 (耗时 0.013 秒)

    ARYLOXY PIPERIDINYL INDOLES FOR TREATING DEPRESSION
    2.
    发明公开
    ARYLOXY PIPERIDINYL INDOLES FOR TREATING DEPRESSION 审中-公开
    芳PIPERIDINYLINDOLE用于治疗抑郁症

    公开(公告)号：EP1349848A2

    公开(公告)日：2003-10-08

    申请号：EP01985615.2

    申请日：2001-11-09

    申请人： Wyeth

    发明人： MEWSHAW, Richard, Eric ,  ZHOU, Ping ,  ZHOU, Dahui

    IPC分类号： C07D401/00

    CPC分类号： C07D401/14

    摘要： This invention provides aryloxy indole derivatives which are useful for the treatment of diseases affected by disorders of the serotonin-affected neurological systems, such as depression and anxiety, the compounds having formula (I) wherein R1 is H or alkyl; R2, R3, and R4 are H, alkyl, or halogen; X is H, halogen, CN, or C1-C6 alkoxy; Z is (CH2)n or carbonyl; n is 1 or 2; and the dashed line indicates an optional double bond; or a pharmaceutically acceptable salt thereof.

    N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION
    3.
    发明授权
    N-ARYLOXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF DEPRESSION 有权
    N-二ARYLOXYETHYLAMINDERIVATE治疗抑郁症

    公开(公告)号：EP1068184B1

    公开(公告)日：2002-09-04

    申请号：EP99915318.2

    申请日：1999-04-07

    申请人： Wyeth

    发明人： MEWSHAW, Richard, Eric ,  ZHOU, Dahui ,  ZHOU, Ping

    IPC分类号： C07D209/16 ,  C07D405/12 ,  C07D403/12 ,  A61K31/40

    CPC分类号： C07D403/12 ,  C07D209/14 ,  C07D405/12

    摘要： Compounds effective in treating disorders of the serotonin-affected neurological systems are provided, such compounds having (I), wherein: R1 and R2 are each, independently, hydrogen, halogen, CF3, lower alkyl, lower alkoxy, MeSO2, or together can form a 5-7 membered carbocyclic or heterocyclic ring; R3 is alkoxy, halogen, hydrogen or carbamoyl; R4 is hydrogen, hydroxy, lower alkyl, or lower alkoxy; R5 is hydrogen, lower alkyl, or halogen; R6 is hydrogen, lower alkyl, or phenyl; R7 is hydrogen, loyer alkyl, lower alkoxy, halogen, CN, CF3, or hydroxy; and X is (CH2)n, wherein n is 0 to 3; or pharmaceutically acceptable salts thereof.

    INDOLYLALKYLPYRIDIN-2-AMINES FOR THE INHIBITION OF BETA-SECRETASE
    7.
    发明公开
    INDOLYLALKYLPYRIDIN-2-AMINES FOR THE INHIBITION OF BETA-SECRETASE 审中-公开
    用于抑制β-分泌酶的吲哚基木糖基吡啶-2-胺

    公开(公告)号：EP2064201A2

    公开(公告)日：2009-06-03

    申请号：EP07838193.6

    申请日：2007-09-14

    申请人： Wyeth

    发明人： YAN, Yinfa ,  ZHOU, Ping ,  FAN, Yi ,  ROBICHAUD, Albert Jean ,  MALAMAS, Michael Sotirios

    IPC分类号： C07D401/06

    CPC分类号： C07D401/06

    摘要： The present invention provides an indolylalkylpyridin-2-amine compound of formula I. The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles.

    摘要翻译： 本发明提供式I的吲哚基烷基吡啶-2-胺化合物。本发明还提供了用于其抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。