公开(公告)号：EP2170875A1

公开(公告)日：2010-04-07

申请号：EP08781841.5

申请日：2008-07-15

申请人： Wyeth LLC

发明人： GROSS, Jonathan Laird ,  ROBICHAUD, Albert Jean ,  MAZZACANI, Alessandro ,  WILLIAMS, Marla Jean

IPC分类号： C07D413/10 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/427 ,  A61K31/445 ,  A61K31/535 ,  A61P25/00

CPC分类号： C07D413/10 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.

摘要翻译： 本发明提供式（I）化合物及其用于治疗与组胺-3受体相关或受其影响的中枢神经系统疾病的用途。

公开(公告)号：EP2137161A1

公开(公告)日：2009-12-30

申请号：EP08727031.0

申请日：2008-03-20

申请人： Wyeth

发明人： MALAMAS, Michael Sotirios ,  ROBICHAUD, Albert Jean ,  PORTE, Alexander Michael ,  SOLVIBILE, William Ronald ,  MORRIS, Koi Michele ,  ANTANE, Schuyler Adam ,  KIM, Ji-ln ,  MCDEVITT, Robert Emmett

IPC分类号： C07D233/88

CPC分类号： C07D233/88

摘要： The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula (I) The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles.

公开(公告)号：EP2004659A1

公开(公告)日：2008-12-24

申请号：EP07755095.2

申请日：2007-04-09

申请人： Wyeth

发明人： ELOKDAH, Hassan, Mahmoud ,  GREENFIELD, Alexander, Alexei ,  GROSANU, Cristina ,  ROBICHAUD, Albert Jean

IPC分类号： C07D498/06 ,  A61K31/5383 ,  A61P25/00

CPC分类号： C07D498/06

摘要： The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor (I) .

公开(公告)号：EP2200998A1

公开(公告)日：2010-06-30

申请号：EP08830104.9

申请日：2008-09-11

申请人： Wyeth LLC

发明人： ZHOU, Dahui ,  GROSS, Jonathan Laird ,  ROBICHAUD, Albert Jean

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/4025 ,  A61K31/435 ,  A61P25/00

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14

摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.

摘要翻译： 本发明提供式（I）化合物及其用于治疗与组胺-3受体相关或受其影响的中枢神经系统疾病的用途。

公开(公告)号：EP2155719A1

公开(公告)日：2010-02-24

申请号：EP08769666.2

申请日：2008-05-23

申请人： Wyeth LLC

发明人： ZHOU, Dahui ,  SZE, Jean Y. ,  GROSS, Jonathan Laird ,  ROBICHAUD, Albert Jean

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D407/14 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4184 ,  A61P25/00

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D405/14

摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor, wherein R3 and R4 are taken together with the atom to which they are attached to form an optionally substituted monocyclic 5-membered aromatic ring system optionally containing one or two additional heteroatoms selected from N, O or S or an optionally substituted fused bicyclic or tricyclic 9- to 15-membered aromatic ring system optionally containing one to three additional heteroatoms selected from N, O or S; and where R1, R2, R5, R6 and x are as defined herein.

公开(公告)号：EP1928841A1

公开(公告)日：2008-06-11

申请号：EP06815185.1

申请日：2006-09-22

申请人： Wyeth

发明人： MALAMAS, Michael Sotirios ,  ERDEI, James Joseph ,  FOBARE, William Floyd ,  QUAGLIATO, Dominick Anthony ,  ANTANE, Schuyler Adam ,  ROBICHAUD, Albert Jean

IPC分类号： C07D233/88

CPC分类号： C07D233/88 ,  C07D401/12 ,  C07D409/12

摘要： The present invention provides a 2-amino-5-[4-(difluoromethoxy)phenyl]-5-3,5-dihydro-phenylimidazol-4-one compound of formula (I) The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles.

公开(公告)号：EP2144884A2

公开(公告)日：2010-01-20

申请号：EP08727089.8

申请日：2008-03-20

申请人： Wyeth

发明人： MALAMAS, Michael Sotirios ,  ROBICHAUD, Albert Jean ,  PORTE, Alexander, Michael ,  MORRIS, Koi, Michele ,  SOLVIBILE, William, Ronald ,  KIM, Ji-in

IPC分类号： C07D233/70

CPC分类号： C07D233/70 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： The present invention provides compounds and methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles.

公开(公告)号：EP1931640A2

公开(公告)日：2008-06-18

申请号：EP06801007.3

申请日：2006-08-08

申请人： Wyeth

发明人： ELOKDAH, Hassan, Mahmoud ,  GREENFIELD, Alexander Alexei ,  LIU, Kevin ,  MCDEVITT, Robert Emmett ,  MCFARLANE, Geraldine Ruth ,  GROSANU, Cristina ,  LO, Jennifer, Rebecca ,  LI, Yanfang ,  ROBICHAUD, Albert Jean ,  BERNOTAS, Ronald Charles

IPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D403/06 ,  A61K31/40 ,  A61P25/00

CPC分类号： C07D231/56 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12 ,  C07D413/12

摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

公开(公告)号：EP2064201A2

公开(公告)日：2009-06-03

申请号：EP07838193.6

申请日：2007-09-14

申请人： Wyeth

发明人： YAN, Yinfa ,  ZHOU, Ping ,  FAN, Yi ,  ROBICHAUD, Albert Jean ,  MALAMAS, Michael Sotirios

IPC分类号： C07D401/06

CPC分类号： C07D401/06

摘要： The present invention provides an indolylalkylpyridin-2-amine compound of formula I. The present invention also provides methods for the use thereof to inhibit ß-secretase (BACE) and treat ß-amyloid deposits and neurofibrillary tangles.

摘要翻译： 本发明提供式I的吲哚基烷基吡啶-2-胺化合物。本发明还提供了用于其抑制β-分泌酶（BACE）和治疗β-淀粉样沉积物和神经原纤维缠结的方法。

公开(公告)号：EP2029550A2

公开(公告)日：2009-03-04

申请号：EP07795389.1

申请日：2007-05-25

申请人： Wyeth

发明人： LIU, Kevin ,  LO, Jennifer Rebecca ,  ROBICHAUD, Albert Jean ,  ELOKDAH, Hassan Mahmoud

IPC分类号： C07D231/56 ,  C07D403/12 ,  A61K31/416 ,  A61K31/454 ,  A61P25/28

CPC分类号： C07D401/12 ,  C07D231/56

摘要： The present invention provides a compound of formula (I) and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.

摘要翻译： 本发明提供了式（I）化合物及其用于治疗与5-HT 6受体相关或受其影响的中枢神经系统病症的用途。