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1.发明公开IMMUNOGLOBULIN SUPERFAMILY VARIANTS EXPRESSED IN MESENCHYMAL CELLS AND THERAPEUTIC USES THEREOF 有权超表达了间充质细胞的免疫球蛋白的变体及其治疗用途
公开(公告)号：EP1389236A2
公开(公告)日：2004-02-18
申请号：EP02712231.6
申请日：2002-02-20
发明人： ZIPORI, Dov , SHAV-TAL, Yaron , BARDA-SAAD, Mira
IPC分类号： C12N15/13 , C12N15/63 , C12N15/11 , C12N5/10 , C07K14/705 , C07K16/28 , G01N33/68 , A61K35/28 , A61K31/7088 , A61P17/02 , A61P35/00
CPC分类号： C07K14/7051 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/70503 , C07K16/00
摘要： Mesenchymal cells are unexpectedly found to express specific truncated versions of immunoglobulin (Ig) superfamily members, namely T cell receptors and related proteins of the immunoglobulin superfamily, as exemplified by the ω heavy chain. Mesenchymal T cell receptor and Ig heavy chain gene products either directly or indirectly control hemopoetic stem cells. Antisense therapy and antibodies can be used to reduce TCR and Ig heavy chain mediated functions. Conversely, overexpression of the TCR and/or Ig heavy chain can be used to induce hemopoesis, for example in stem cell transplantation or following chemotherapy.
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公开(公告)号：EP2804944A1
公开(公告)日：2014-11-26
申请号：EP13705262.7
申请日：2013-01-14
发明人： ZIPORI, Dov , SHOSHANI, Ofer
IPC分类号： C12N5/071
CPC分类号： C12N5/0696 , C12N5/0663 , C12N13/00 , C12N2500/02 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2506/1353 , C12N2510/00
摘要： The invention relates to induction of reprogramming of somatic cells, by methods which require mild growth conditions. Disclosed are methods of inducing dedifferentiation of mesenchymal stromal cell (MSC), by seeding or incubating mesenchymal stromal cells (MSCs) at low density, and without introduction or expression of exogenous genes in the cells.
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3.发明授权IMMUNOGLOBULIN SUPERFAMILY VARIANTS EXPRESSED IN MESENCHYMAL CELLS AND THERAPEUTIC USES THEREOF 有权超表达了间充质细胞的免疫球蛋白的变体及其治疗用途
公开(公告)号：EP1389236B1
公开(公告)日：2006-10-18
申请号：EP02712231.6
申请日：2002-02-20
发明人： ZIPORI, Dov , SHAV-TAL, Yaron , BARDA-SAAD, Mira
IPC分类号： C12N15/13 , C12N15/63 , C12N15/11 , C12N5/10 , C07K14/705 , C07K16/28 , G01N33/68 , A61K35/28 , A61K31/7088 , A61P17/02 , A61P35/00 , C07K16/00
CPC分类号： C07K14/7051 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/70503 , C07K16/00
摘要： Mesenchymal cells are unexpectedly found to express specific truncated versions of immunoglobulin (Ig) superfamily members, namely T cell receptors and related proteins of the immunoglobulin superfamily, as exemplified by the upsilon heavy chain. Mesenchymal T cell receptor and Ig heavy chain gene products either directly or indirectly control hemopoetic stem cells. Antisense therapy and antibodies can be used to reduce TCR and Ig heavy chain mediated functions. Conversely, overexpression of the TCR and/or Ig heavy chain can be used to induce hemopoesis, for example in stem cell transplantation or following chemotherapy.
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