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公开(公告)号：EP1424897A2
公开(公告)日：2004-06-09
申请号：EP02775172.6
申请日：2002-09-12
IPC分类号： A01N43/04
CPC分类号： C07K14/005 , A61K35/768 , A61K48/00 , C12N7/00 , C12N2760/18122 , C12N2760/18132 , C12N2760/18164
摘要： The present invention discloses lentogenic viral strains useful in the treatment of cancer. A preferred viral strain of Newcastle disease Virus (NDV) is specifically characterized in terms of biological activities. The present invention further discloses treatment of cancer by application of a clonal NDV strain to tumors. According to an alternative preferred embodiment the use of at least one isolated viral protein or subunit or analog thereof, or an isolated polynucleotide encoding same, is used in the treatment of cancer.
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2.发明授权
公开(公告)号：EP0693925B1
公开(公告)日：2002-02-13
申请号：EP94914102.2
申请日：1994-04-08
申请人： BIO-TECHNOLOGY GENERAL CORPORATION , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
发明人： WERBER, Moshe M. , ZEELON, Elisha P. , LEVANON, Avigdor , GUY, Rachel , GOLDLUST, Arie , RIGBI, Meir , PANET, Amos , FISCHER, Meir
CPC分类号： C07K14/815 , A61K38/00 , C07K16/38
摘要： The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr - gly where tyr - gly is identical to the sequence shown in Figure 10, and wherein X is methionine or absent and wherein asn may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.
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公开(公告)号：EP1737957A1
公开(公告)日：2007-01-03
申请号：EP05735708.9
申请日：2005-04-21
发明人： HONIGMAN, Alik , PANET, Amos , LEVAOT, Noam
IPC分类号： C12N15/11 , A61K31/713
CPC分类号： C12N15/111 , C12N2310/14 , C12N2330/30
摘要： The present invention provides methods for designing a sequence for efficient short interference RNA molecules. In particular, the present invention defines a universal target for siRNA derived from the consensus sequence of the polyadenylation signal in conjunction with unique sequences for gene silencing and inhibition of viral replication in a eukaryotic host cell. The present invention further provides methods for the treatment and prevention of diseases and disorders by silencing a gene of a virus, an oncogene, genes encoding transcription factors and many other diseases related genes.
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公开(公告)号：EP0693925A1
公开(公告)日：1996-01-31
申请号：EP94914102.0
申请日：1994-04-08
申请人： BIO-TECHNOLOGY GENERAL CORP. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
发明人： WERBER, Moshe M. , ZEELON, Elisha P. , LEVANON, Avigdor , GUY, Rachel , GOLDLUST, Arie , RIGBI, Meir , PANET, Amos , FISCHER, Meir
IPC分类号： C12N15 , A61K38 , A61P7 , A61P31 , A61P43 , C07K1 , C07K14 , C07K16 , C12N1 , C12N9 , C12P21 , C12R1
CPC分类号： C07K14/815 , A61K38/00 , C07K16/38
摘要： The present invention provides a recombinant polypeptide having the amino acid sequence X-tyr?26 - gly110¿ where tyr?26 - gly110¿ is identical to the sequence shown in Figure 10, and wherein X is methionine or absent and wherein asn72 may be substituted by pro. The invention further provides a method of producing the polypeptide which comprises transforming a host cell with an expression plasmid encoding the polypeptide, culturing the transformed host cell so that the cell produces the polypeptide encoded by the plasmid, and a method of recovering the polypeptide so produced.
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