公开(公告)号：EP2890699A1

公开(公告)日：2015-07-08

申请号：EP13756985.1

申请日：2013-08-28

申请人： Zoetis LLC

发明人： BILLEN, Denis ,  BIRCHMEIER, Matthew Joseph ,  VANDERROEST, Ronald J.

IPC分类号： C07D491/107 ,  A61P33/00 ,  A61K31/4155

CPC分类号： C07D491/107 ,  A61K31/422 ,  A61K45/06 ,  C07B2200/13

摘要： The present invention relates to novel crystalline modifications of 1-(5′-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoro-methyl)-4,5-dihydroisoxazol-3-yl)-3′H-spiro[azetidine-3,1′-isobenzofuran]-1-yl)-2-(methylsulfonyl)ethanone. The present invention also describes compositions and methods of treating a parasitic infection or infestation in an animal in need thereof. The present invention also relates to processes for making the crystalline forms.

摘要翻译： 本发明涉及1-（5' - （5-（3,5-二氯-4-氟苯基）-5-（三氟甲基）-4,5-二氢异恶唑-3-基）-3 'H-螺[吖丁啶-3,1'-异苯并呋喃] -1-基）-2-（甲基磺酰基）乙酮。 本发明还描述了在有需要的动物中治疗寄生虫感染或侵染的组合物和方法。 本发明还涉及制备结晶形式的方法。

公开(公告)号：EP2822934A1

公开(公告)日：2015-01-14

申请号：EP13710219.0

申请日：2013-03-01

申请人： Zoetis LLC

发明人： CURTIS, Michael ,  DUCLOS, Brian, A. ,  EWIN, Richard, A. ,  JOHNSON, Paul, D. ,  JOHNSON, Timothy, A. ,  VAIRAGOUNDAR, Rajendran ,  BILLEN, Denis ,  GOODWIN, Richard, M. ,  HABER-STUK, Andrea, K. ,  KYNE, Graham, M. ,  SHEEHAN, Susan, M. K.

IPC分类号： C07D333/20 ,  C07D401/06 ,  C07D239/26 ,  C07D413/06 ,  C07D241/12 ,  C07D417/06 ,  C07D271/06 ,  C07D277/28 ,  C07D285/12 ,  C07D213/38 ,  A61K31/4995 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/4245 ,  A61K31/4418

CPC分类号： C07F9/58 ,  C07D213/16 ,  C07D213/38 ,  C07D213/40 ,  C07D239/26 ,  C07D241/12 ,  C07D271/06 ,  C07D277/28 ,  C07D285/12 ,  C07D333/20 ,  C07D401/04 ,  C07D401/06 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/10 ,  C07D491/107 ,  C07D495/10 ,  C07D513/04 ,  C07F9/582

摘要： The present invention provides novel phenicol derivatives of formula I, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.

公开(公告)号：EP2809667A1

公开(公告)日：2014-12-10

申请号：EP13703287.6

申请日：2013-01-29

申请人： Zoetis LLC

发明人： BILLEN, Denis ,  GREENWOOD, Sean David William ,  STUK, Timothy Lee

IPC分类号： C07D413/10

CPC分类号： C07D413/10

摘要： The invention recites a chiral process for the synthesis of isoxazoline azetidine phenyl substituted derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, processes for making, and their use as a parasiticide in an animal. The variables
* , R
1a , R
1b , R
1c , R
2 , and R
3 are as described herein

公开(公告)号：EP2683723A1

公开(公告)日：2014-01-15

申请号：EP12709376.3

申请日：2012-02-23

申请人： Zoetis LLC

发明人： BILLEN, Denis ,  CHUBB, Nathan Anthony Logan ,  CURTIS, Michael ,  GREENWOOD, Sean DW ,  MENON, Sanjay ,  STUK, Timothy ,  VAILLANCOURT, Valerie A.

IPC分类号： C07D491/10 ,  A01N43/80

CPC分类号： C07D491/10 ,  A01N43/90

摘要： The invention recites spirocyclic isoxazoline derivatives of Formula (V.1), Formula (V.2), Formula (V.1.1), and Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use as a parasiticide in an animal. The variables A, V, Z, W
1 , W
2 , W
3 , W, Y, X, R
1a , R
1b , R
1c , R
2 , R
3 , R
4 , n, and --- are as described herein.