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    METHOD OF LABELLING INTERFERONS WITH PEG
    2.
    发明公开
    METHOD OF LABELLING INTERFERONS WITH PEG 审中-公开
    VERFAHREN ZUR MARKIERUNG VON干燥麻醉剂PEG

    公开(公告)号：EP2429567A1

    公开(公告)日：2012-03-21

    申请号：EP10720802.7

    申请日：2010-05-17

    申请人： Almac Sciences (Scotland) Limited

    发明人： ROBERTS, Jennifer ,  COTTON, Graham

    IPC分类号： A61K38/21 ,  C07K14/555

    CPC分类号： C07K14/56 ,  A61K38/00 ,  A61K47/60

    摘要： A method of site specific labelling of an interferon molecule is provided. The method comprises the steps: a) providing a label molecule comprising a PEG moiety having an aldehyde or ketone moiety; b) providing an interferon molecule having a C terminal hydrazide moiety; and c) allowing the aldehyde or ketone moiety of the PEG moiety to react with the C terminal hydrazide of the interferon molecule to form a labelled interferon molecule, which comprises a PEG moiety attached to the C terminus of the interferon molecule via a hydrazone bond. Interferon molecules labelled using such a method are also described.

    摘要翻译： 提供了干扰素分子的位点特异性标记方法。 该方法包括以下步骤：a）提供包含具有醛或酮部分的PEG部分的标记分子; b）提供具有C末端酰肼部分的干扰素分子; 和c）允许PEG部分的醛或酮部分与干扰素分子的C末端酰肼反应以形成标记的干扰素分子，其包含通过腙键连接至干扰素分子的C末端的PEG部分。 还描述了使用这种方法标记的干扰素分子。

    A TAG FOR PURIFICATION OF PEPTIDES
    8.
    发明授权
    A TAG FOR PURIFICATION OF PEPTIDES 有权
    每天用于清洁肽

    公开(公告)号：EP1628998B1

    公开(公告)日：2011-02-23

    申请号：EP04735606.8

    申请日：2004-06-01

    申请人： Almac Sciences (Scotland) Limited

    发明人： HAY, Alastair ,  COTTON, Graham ,  RAMAGE, Robert

    IPC分类号： C07K1/13 ,  C07K1/16

    CPC分类号： C07K1/13 ,  C07D213/38

    摘要： Disclosed is a tag for purification of peptides, The tag structure facilitates the easy cleavage of a bond formed between the tag molecule and a peptide to which it is bound under conditions which minimise, indeed preferably prevent, damage to the peptide. The tag molecules of the invention may be used to separate and/or purify a peptide from a mixture of peptides and/or other components.

    METHOD OF PEPTIDE SYNTHESIS
    10.
    发明授权
    METHOD OF PEPTIDE SYNTHESIS 有权
    肽合成方法

    公开(公告)号：EP1648930B1

    公开(公告)日：2009-07-01

    申请号：EP04767950.1

    申请日：2004-07-30

    申请人： Almac Sciences (Scotland) Limited

    发明人： STEWART, Andrew Smith Johnstone

    IPC分类号： C07K14/52 ,  C07K1/04

    CPC分类号： C07K1/042 ,  C07K14/521

    摘要： A method for synthesising a given peptide or its derivative which contains a proline residue or a proline derivative, at proximity to, or at, the C-terminal end of said peptide is provided. The method comprises a) synthesising on a first resin a C­terminal portion of said peptide, o r its derivative, comprising at least three successive amino acid residues or their derivatives, by successive coupling of selected amino acids, small peptides or their derivatives, b) cleaving the C-terminal portion from said first resin; c) reattaching said C-terminal portion to a second resin which is generally suitable for the synthesis of peptides but is unsuitable for the formation of peptides having a proline residue positioned atthe C-terminal end of said peptide; and d)coupling selected amino acids, small peptides or derivatives to the C-terminal portion.

    摘要翻译： 提供了在所述肽的C末端附近或其附近合成含有脯氨酸残基或脯氨酸衍生物的给定肽或其衍生物的方法。 该方法包括a）通过连续偶联选择的氨基酸，小肽或其衍生物，在第一树脂上合成包含至少三个连续氨基酸残基或其衍生物的所述肽或其衍生物的C端部分，b）裂解 来自所述第一树脂的C端部分; c）将所述C-末端部分重新连接至第二树脂，该第二树脂通常适用于肽的合成，但不适于形成位于所述肽的C-末端的具有脯氨酸残基的肽; 和d）将选择的氨基酸，小肽或衍生物偶联至C端部分。