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    PERCUTANEOUSLY ABSORBABLE PREPARATION, PERCUTANEOUSLY ABSORBABLE PREPARATION HOLDING SHEET, AND PERCUTANEOUSLY ABSORBABLE PREPARATION HOLDING EQUIPMENT
    1.
    发明公开
    PERCUTANEOUSLY ABSORBABLE PREPARATION, PERCUTANEOUSLY ABSORBABLE PREPARATION HOLDING SHEET, AND PERCUTANEOUSLY ABSORBABLE PREPARATION HOLDING EQUIPMENT 审中-公开
    制备的经皮吸收，薄膜的经皮吸收和支持研制的经皮吸收研制

    公开(公告)号：EP1844763A1

    公开(公告)日：2007-10-17

    申请号：EP06712623.5

    申请日：2006-01-30

    申请人： BioSerenTach Co., Ltd.

    发明人： TAKADA, Kanji

    IPC分类号： A61K9/00 ,  A61K38/00 ,  A61K38/21 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/42 ,  A61K48/00 ,  A61P37/00 ,  A61M37/00

    CPC分类号： A61K9/7007 ,  A61K9/0021 ,  A61K31/375 ,  A61K31/727 ,  A61K38/21 ,  A61K38/28 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0061

    摘要： Self-dissolving needle-like or filamentous shape percutaneously absorbable preparations, by which inherently poorly absorbable drugs into the body through the skin is efficiently administered. The preparations are made of at least one material selected from the group consisting of proteins, polysaccharides, polyvinyl alcohols, carboxyvinyl polymers and sodium polyacrylic acids. An active substance contained therein is released in a sustained-release fashion (1) by forming a water-insoluble layer on its surface, (2) by holding the active substance in porous materials, or (3) by imparting a long-acting characteristic to the active substance. The present invention also provides a sheet-like carrier for holding the preparations on at least one of the sides thereof, and a piece of equipment for holding the preparations so as to facilitate the administration of them.

    摘要翻译： 自溶针状或丝状形状透皮吸收制剂，通过其固有的吸收差的药物进入通过皮肤身体管理工作效率。 这些制剂是由选自蛋白质，多糖，聚乙烯醇，羧乙烯基聚合物和钠聚丙烯酸中的至少一种材料制成。 其中所含的活性物质是在持续释放的方式（1）通过在其表面上形成一个水不溶性层，（2）由保持在多孔材料的活性物质，或释放（3）通过赋予长效特性 到的活性物质。 本发明因此提供了用于保持在其侧面中的至少一个的准备的片状的载体，和用于保持制剂，以便于它们的施用一台设备。

    MICRO-NEEDLE PREPARATION ADMINISTRATION MEMBER FOR INTRADERMAL PLACEMENT OF TARGET SUBSTANCE AND APPARATUS FOR RAPID ADMINISTRATION OF MICRO-NEEDLE PREPARATION
    2.
    发明公开
    MICRO-NEEDLE PREPARATION ADMINISTRATION MEMBER FOR INTRADERMAL PLACEMENT OF TARGET SUBSTANCE AND APPARATUS FOR RAPID ADMINISTRATION OF MICRO-NEEDLE PREPARATION 审中-公开
    微针制剂施用组元素微针制剂的快速交付的目标物质的皮内布置和设备

    公开(公告)号：EP3117867A1

    公开(公告)日：2017-01-18

    申请号：EP14885596.8

    申请日：2014-03-12

    申请人： BioSerenTach Co., Ltd. ,  Labo Juversa Co., Ltd.

    发明人： TAKADA, Kanji ,  ONO, Ichiro

    IPC分类号： A61M37/00 ,  A61K38/00

    CPC分类号： A61M37/0015 ,  A61K9/0014 ,  A61K38/00 ,  A61K38/1825 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2202/07 ,  A61M2202/097

    摘要： The problem of the invention is to provide a microneedle preparation administration apparatus that prevents overdosing caused by duplicate administration within a treatment range of skin, more reliably administers a prescribed dose of a growth factor at an intended optional depth in the dermis, exhibits an intended effect, and avoids pigmentation side effects. The solution to the problem is a microneedle preparation administration apparatus comprising: a guide tube; a pedestal in which at least a part thereof including a front end surface is housed within the guide tube and slides in length direction; and driving means for driving the pedestal toward a front end part of the guide tube, and microneedle preparations being to be attached to the front end surface of the pedestal, and the microneedle preparations being to be pressed out from a front end part of the guide tube, wherein the microneedle preparation has a first portion having a tip end part and containing an objective substance, and a second portion having a bottom part and not containing the objective substance, and the front end surface of the pedestal is struck on skin at a collision pressure of 30 N to 200 N per 1 cm 2 .

    摘要翻译： 该发明的问题是提供一种微针制备给药装置并防止过量给药通过重复给药皮肤的治疗范围内造成的，更可靠地在负责管理的生长因子的预定用量在真皮预期任意深度，在预期的效果展品 ，避免色素沉着的副作用。 到该溶液问题是微针制备给药装置，包括：引导管; 基座，其中至少包括其前端面的一部分被引导管和在长度方向上滑动，内坐落; 和驱动装置，用于驱动所述基座向所述引导管的前端部，以及微针制剂是将被安装在台座的前端面，和微针的制剂是为从导向件的前端部压出 管，worin微针制备具有包括前端部和目标物质的含，和具有第二部分的底部部分和不包含目标物质，和台座的前端面在被击打在皮肤上的第一部分 的30 N至200N碰撞压力每1cm 2。

    MICRONEEDLE PATCH, METHOD FOR MANUFACTURING SAME, AND APPARATUS FOR MANUFACTURING MICRONEEDLE ARRAY
    4.
    发明公开
    MICRONEEDLE PATCH, METHOD FOR MANUFACTURING SAME, AND APPARATUS FOR MANUFACTURING MICRONEEDLE ARRAY 审中-公开
    MICRONEEDLE PATCH，其制造方法及用于制造MICRONEEDLE ARRAY的装置

    公开(公告)号：EP3235538A1

    公开(公告)日：2017-10-25

    申请号：EP15869985.0

    申请日：2015-12-15

    申请人： Labo Juversa Co., Ltd. ,  BioSerenTach Co., Ltd.

    发明人： ONO, Ichiro ,  YAMADA, Shinya ,  CHIYAMA, Masateru ,  AKITA, Kensaku ,  UENO, Takako ,  IDE, Yuko ,  NAGAI, Sachi ,  AKAO, Osanobu ,  TAKADA, Kanji

    IPC分类号： A61M37/00 ,  B81B1/00

    CPC分类号： B29C39/24 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0053 ,  B05B12/122 ,  B29C65/004 ,  B29L2031/7544 ,  B81B1/00

    摘要： A microneedle patch with which a treatment is reliably completed in a short time when a microneedle is administered into skin or mucous membrane is provided. A microneedle patch (100F) includes a base member (101) and a plurality of microneedles (103g) supported by the base member (101). Each microneedle (103g) includes a top-section layer (104) comprising a biologically active substance to be inserted in dermis (310), and an intermediate layer (106) provided between the top-section layer (104) and the base member (101), having a composition having breaking strength weaker than breaking strength of a composition of the top-section layer (104), and having a thickness of 5 µm and 100 µm inclusive.

    摘要翻译： 本发明提供一种微针贴片，该微针贴片在向皮肤或粘膜给予微针时能够在短时间内可靠地完成治疗。 微针贴片（100F）包括基座构件（101）和由基座构件（101）支撑的多个微针（103g）。 每个微针103g包括包含待插入真皮310中的生物活性物质的顶层部分104以及设置在顶层部分104和基底部件103之间的中间层106。 101），其组成具有断裂强度弱于顶部层（104）的组成的断裂强度，并且具有5μm和100μm（包括端值）的厚度。

    STAMPER FOR MICRONEEDLE SHEET, METHOD FOR MANUFACTURING THE STAMPER, AND METHOD FOR MANUFACTURING MICRONEEDLE USING THE STAMPER
    6.
    发明公开
    STAMPER FOR MICRONEEDLE SHEET, METHOD FOR MANUFACTURING THE STAMPER, AND METHOD FOR MANUFACTURING MICRONEEDLE USING THE STAMPER 审中-公开
    DIE微针板，用于生产和微针法利用母

    公开(公告)号：EP2343101A1

    公开(公告)日：2011-07-13

    申请号：EP10703212.0

    申请日：2010-01-15

    申请人： BioSerenTach Co., Ltd.

    发明人： MOTOI, Masashi ,  HONDA, Kenshin ,  TERADA, Toyoharu ,  OKADA, Tatsuya ,  SATOUCHI, Yoshitomo ,  TAKADA, Kanji

    IPC分类号： A61M37/00 ,  B29C59/02 ,  B81B1/00 ,  B81C1/00

    CPC分类号： A61M37/0015 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C59/02

    摘要： Microneedle sheets are produced by injecting a needle raw material into a stamper formed with a concavity in a base material. However, because the stamper concavity is very small, there is the problem that air cannot escape due to air and surface tension of the material, thereby preventing a needle from being formed in part. The present invention provides a stamper for producing a microneedle sheet. The stamper comprises a sheet-like base material including a conical concavity formed from a first surface of the sheet-like base material toward a second surface thereof; and a through-hole formed from a bottom of the concavity toward the second surface. Air can escape via this through-hole, allowing a microneedle sheet which is filled with a needle raw material as far as the bottom of the concavity to be obtained.

    摘要翻译： 微针片材通过注入针原料与在基体材料的凹部形成的压模制造。 然而，由于压模凹部是非常小的，有问题的并空气不能逸出由于材料的空气和表面张力，由此从部分形成防止针。 本发明提供一种生产微针片材的压模。 压模包括片状基体材料包括从朝向其第二表面的片状基体材料的第一表面上形成的锥状凹部; 和通孔从朝着第二表面的凹部的底部形成。 空气可以通过该通孔逸出，允许微针片材的所有其远填充有针原料作为凹部的底面到获得。