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公开(公告)号：EP2311947A1
公开(公告)日：2011-04-20
申请号：EP09172961.6
申请日：2009-10-14
发明人： Carell, Thomas
CPC分类号： C12P21/005
摘要： The present invention refers to a method of incorporating non-genetically encoded amino acids at single or multiple positions of a protein and optionally the further modification of the side chains of said non-genetically encoded amino acids, e.g. by introduction of glycan groups. Further, the present invention refers to novel single or multiple glycosylated proteins.
摘要翻译： 本发明涉及在蛋白质的单个或多个位置掺入非遗传编码氨基酸的方法，以及任选地对所述非遗传编码氨基酸的侧链的进一步修饰，例如， 通过引入聚糖基团。 此外，本发明涉及新的单糖或多糖基化蛋白。
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2.发明公开HETEROARYL-SUBSTITUIERTE DICYANOPYRIDINE UND IHRE VERWENDUNG ZUR BEHANDLUNG KARDIOVASKULÄRER ERKRANKUNGEN 有权杂芳基取代dicyanopyridines和心血管疾病的治疗用途
公开(公告)号：EP2274299A1
公开(公告)日：2011-01-19
申请号：EP09720733.6
申请日：2009-02-26
发明人： MEIBOM, Daniel , VAKALOPOULOS, Alexandros , ALBRECHT-KÜPPER, Barbara , ZIMMERMANN, Katja , NELL, Peter , SÜSSMEIER, Frank
IPC分类号： C07D401/14 , C07D409/04 , C07D413/14 , C07D417/14 , A61K31/4427 , A61P9/00 , A61P3/00
CPC分类号： C07D417/14 , C07D401/14 , C07D409/04 , C07D413/14
摘要： The present application relates to new heteroaryl-substituted dicyanopyridines having formula (I), to a method for the production thereof, to the use thereof for treatment and/or prevention of diseases and also the use thereof for production of pharmaceuticals for treatment and/or prevention of diseases, preferably for treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：EP2221620A3
公开(公告)日：2010-11-24
申请号：EP10164475.5
申请日：2003-08-11
发明人： Yalkinoglu, Oezkan, Dr. , König, Gerhard, Dr. , Hochstrasser, Denis Francois, Prof.Dr. , Sanchez, Jean-Charles, Dr. , Carette, Odile, Dr.
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , C07K14/70539 , C07K14/805 , C07K14/8139 , G01N2800/2821
摘要： A method for assessing the state of Alzheimer's disease in patients is disclosed. A method for monitoring the progression of Alzheimer's disease in patients is also disclosed. The method applies detection of specific markers in body fluids (e.g. CSF), using mass spectrometric analysis (SELDI-TOF MS). The specific markers are: human cystatin C, human beta-2-microglobulin, human myoglobin neurosecretory protein VGF or fragments of these proteins.
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4.发明公开SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权取代的2,3-二氢[1,2-C]喹唑啉衍生物，其用于治疗过度增生性疾病和血管形成有关的疾病中，合适于治疗
公开(公告)号：EP2096919A4
公开(公告)日：2010-11-17
申请号：EP07862580
申请日：2007-12-05
发明人： HENTEMANN MARTIN , WOOD JILL , SCOTT WILLIAM , MICHELS MARTIN , CAMPBELL ANN-MARIE , BULLION ANN-MARIE , ROWLEY R BRUCE , REDMAN ANIKO
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： A61K31/5377 , A01N43/90 , A61K31/519 , C07D487/04
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公开(公告)号：EP2094284A2
公开(公告)日：2009-09-02
申请号：EP07869677.0
申请日：2007-12-20
发明人： HERMISTON, Terry , KUHN, Irene
IPC分类号： A61K35/76 , C12N7/00 , C12N15/861
CPC分类号： C12N15/86 , A61K35/13 , C12N7/00 , C12N2710/10343 , C12N2710/10351
摘要： The present invention relates to a method for the production of onolytic adenoviruses having increased potency and their therapeutic applications for cancer. Recombinant adenoviruses and methods to produce them are provided.
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公开(公告)号：EP2087359A1
公开(公告)日：2009-08-12
申请号：EP07818642.6
申请日：2007-10-02
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
CPC分类号： G01N33/573 , C12Q1/37 , G01N2333/948
摘要： The invention provides PRSS23 which is associated with the cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of PRSS23 as well as pharmaceutical compositions comprising such compounds. The invention also provides PRSS23 as a biomarker for diseases as cardiovascular diseases, hematological diseases, neurological diseases, respiratory diseases, gastroenterological diseases and urological diseases.
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公开(公告)号：EP2074429A1
公开(公告)日：2009-07-01
申请号：EP07818669.9
申请日：2007-10-04
发明人： GOLZ, Stefan , SUMMER, Holger , GEERTS, Andreas , BRÜGGEMEIER, Ulf , ALBRECHT-KÜPPER, Barbara , KLEIN, Martina , STEPPAN, Sonja , ELLINGHAUS, Peter , D'URSO, Donatella , SEEWALD, Michael , MILTING, Hendrik
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N2800/06 , G01N2800/12 , G01N2800/22 , G01N2800/28 , G01N2800/32 , G01N2800/34
摘要： The invention provides CTGF which is associated with the cardiovascular diseases and hematological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases and hematological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of CTGF as well as pharmaceutical compositions comprising such compounds. The invention also provides CTGF as a biomarker for diseases as cardiovascular diseases and hematological diseases
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公开(公告)号：EP2074135A2
公开(公告)日：2009-07-01
申请号：EP07818173.2
申请日：2007-09-07
发明人： SRINIVASAN, Ananth , LEHMANN, Lutz , RÖHN, Ulrike , STELLFELD, Timo , AMETAMEY, Simon , KLAR, Ulrich , HÖHNE, Aileen , MU, Linjing
CPC分类号： C07K1/13 , A61K49/085 , A61K49/10 , A61K49/14 , A61K51/0491 , C07B59/004 , C07B59/008 , C07F7/0834 , C07F7/0896 , C07F7/12 , C07K7/02 , C07K7/086
摘要： The present invention relates to novel compounds suitable for or already radiolabeled with 18F, methods of making such compounds and use of such compounds for diagnostic imaging. Such labeled vompounds are characerized by Formula II, wherein the moieties F, R1, R2, B1,2, Y1.2,, Z1.2 and E have the meaning as defined in the specification and claims.
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公开(公告)号：EP2070909A1
公开(公告)日：2009-06-17
申请号：EP07076093.9
申请日：2007-12-15
发明人： Kirkland, Thomas , Schwede, Wolfgang , Möller, Carsten , Bäurle, Stefan , Wyrwa, Ralf , Rotgeri, Andrea
IPC分类号： C07C255/58 , C07D211/34 , C07D265/02 , C07D309/14 , C07D335/02 , A61K31/167 , A61K31/536 , A61K31/351 , A61K31/435 , A61K31/382 , A61P5/24 , A61P15/08 , A61P35/00
CPC分类号： C07D317/30 , C07C255/60 , C07C317/46 , C07C2601/08 , C07C2601/14 , C07D211/22 , C07D211/32 , C07D211/34 , C07D213/30 , C07D213/56 , C07D261/20 , C07D265/02 , C07D295/13 , C07D295/155 , C07D295/18 , C07D295/192 , C07D309/06 , C07D317/20 , C07D333/16 , C07D335/02 , C07D401/06 , C07D401/10 , C07D405/06 , C07D405/10 , C07D407/06 , C07D407/10 , C07D409/06 , C07D409/10 , C07D413/12 , C07D413/14
摘要： Die vorliegende Erfindung betrifft nichtsteroidale Progesteronrezeptor-Modulatoren der allgemeinen Formel I,
die Verwendung der Progesteronrezeptor-Modulatoren zur Herstellung von Arzneimitteln sowie pharmazeutische Zusammensetzungen, die diese Verbindungen enthalten.
Die erfindungsgemäßen Verbindungen sind geeignet zur Therapie und Prophylaxe von gynäkologischen Erkrankungen wie Endometriose, Leiomyomen des Uterus, dysfunktionelle Blutungen und Dysmenorrhoe sowie für die Therapie und Prophylaxe von hormonabhängigen Tumoren und zur Verwendung für die weibliche Fertilitätskontrolle sowie für die Hormonersatztherapie.摘要翻译： 本发明涉及通式I，用于制备药物的用途黄体酮受体调节剂和含有这些化合物的药物组合物的非类固醇孕激素受体调节剂。 本发明的化合物适用于治疗和妇科疾病，例如子宫内膜异位症的预防，子宫，功能失调性出血和痛经的平滑肌瘤，以及用于激素依赖性肿瘤的治疗和预防以及用于使用用于女性生育力控制和用于激素替代疗法。
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10.发明公开N-(1-HETARYLPIPERIDIN-4-YL)(HET)ARYLAMIDES AS EP2 RECEPTOR MODULATORS 审中-公开N-（1- HETARYLPIPERIDIN -4-基）（HET）芳基酰胺AS EP2受体的调节剂
公开(公告)号：EP2066654A1
公开(公告)日：2009-06-10
申请号：EP07802347.0
申请日：2007-09-06
发明人： BRÄUER, Nico , BUCHMANN, Bernd , KOPPITZ, Marcus , TER LAAK, Antonius , LANGER, Gernot , LINDENTHAL, Bernhard , PETERS, Olaf , WINTERMANTEL, Tim
IPC分类号： C07D401/04 , C07D215/46 , C07D401/14 , C07D405/14 , C07D409/14 , C07D403/04 , C07D403/14 , A61K31/4709 , A61K31/4706 , A61K31/472 , A61K31/4725 , A61K31/517 , A61P19/10
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
摘要： The present invention relates to (het)aryl-3-[(het)arylpiperidin-4-yl]amides, to processes for their preparation and to their use for producing pharmaceutical compositions for treatment of disorders and indications connected to the EP2 receptor.
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