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1.发明授权MINIATURIZED OPTICAL TWEEZER ARRAY WITH AN ARRAY OF REFLECTIVE ELEMENTS FOR REFLECTING THE LIGHT BACK TO A FOCAL AREA 有权以与阵列ARRAY小型化光学镊子反射元件以将光反射回用焦区
公开(公告)号：EP1934645B1
公开(公告)日：2011-08-17
申请号：EP06809533.0
申请日：2006-10-07
发明人： BOER, Gerben , MERENDA, Fabrice , DELACRETAZ, Guy , SALATHE, René
CPC分类号： G02B21/32
摘要： Apparatus for forming a single or a plurality of threedimensional optical traps, the apparatus comprising: a. A collimated light source that is directed onto an array of focalizing refractive or diffractive elements providing a single or a plurality of focal areas, and b. An array of reflective elements, placed opposite to the said focalizing elements described in a), which reflect back the light into the said focal area. The invention also relates to a method for using this apparatus.
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公开(公告)号：EP1601438B1
公开(公告)日：2009-10-07
申请号：EP03816151.9
申请日：2003-03-08
发明人： FERNANDEZ, Victor , RIDA, Amar , GIJS, Martin
IPC分类号： B01D35/06
CPC分类号： B03C1/035 , B01F13/0059 , B01F13/0818 , B01F2215/0037 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0838 , B01L2400/0406 , B01L2400/043 , B03C1/288 , G01N27/745 , G01N35/0098 , G01N2035/00574 , Y10T436/2575
摘要： A device for transporting magnetic or magnetisable microbeads (25) in a capillary chamber (14) comprises a permanent magnet (10) or an electromagnet (11) for subjecting the capillary chamber to a substantially uniform magnetic field, to apply a permanent magnetic moment to the microbeads (25). At least one planar coil (22) and preferably an array of overlapping coils are located adjacent to the capillary chamber (14) for applying a complementary magnetic field on the microbeads parallel or antiparallel to said substantially uniform magnetic field, to drive the microbeads. An arrangement is provided for switching the current applied to the coil(s) (22) to invert the field produced thereby, to selectively apply an attractive or repulsive driving force on the microbeads (25). The device is usable to transport microbeads for performing chemical and biochemical reactions or assay, as is done for instance in clinical chemistry assays for medical diagnostic purposes.
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公开(公告)号：EP1283869A2
公开(公告)日：2003-02-19
申请号：EP01967602.2
申请日：2001-02-16
发明人： SPERTINI, Francois
IPC分类号： C12N1/00
CPC分类号： C07K14/43572 , A61K38/00
摘要： The present invention provides novel protein named Api m 6. Api m 6 was identified in bee venom and is found in four isoforms, each about 8 kD. The purified Api m 6 can be used to modulate immune responses, e.g., in individuals hypersensitive to bee venom.
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4.发明公开MINIATURIZED OPTICAL TWEEZER ARRAY WITH AN ARRAY OF REFLECTIVE ELEMENTS FOR REFLECTING THE LIGHT BACK TO A FOCAL AREA 有权以与阵列ARRAY小型化光学镊子反射元件以将光反射回用焦区
公开(公告)号：EP1934645A1
公开(公告)日：2008-06-25
申请号：EP06809533.0
申请日：2006-10-07
发明人： BOER, Gerben , MERENDA, Fabrice , DELACRETAZ, Guy , SALATHE, René
CPC分类号： G02B21/32
摘要： Apparatus for forming a single or a plurality of threedimensional optical traps, the apparatus comprising: a. A collimated light source that is directed onto an array of focalizing refractive or diffractive elements providing a single or a plurality of focal areas, and b. An array of reflective elements, placed opposite to the said focalizing elements described in a), which reflect back the light into the said focal area. The invention also relates to a method for using this apparatus.
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公开(公告)号：EP1601438A1
公开(公告)日：2005-12-07
申请号：EP03816151.9
申请日：2003-03-08
发明人： FERNANDEZ, Victor , RIDA, Amar , GIJS, Martin
IPC分类号： B01D35/06
CPC分类号： B03C1/035 , B01F13/0059 , B01F13/0818 , B01F2215/0037 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0838 , B01L2400/0406 , B01L2400/043 , B03C1/288 , G01N27/745 , G01N35/0098 , G01N2035/00574 , Y10T436/2575
摘要： A device for transporting magnetic or magnetisable microbeads (25) in a capillary chamber (14) comprises a permanent magnet (10) or an electromagnet (11) for subjecting the capillary chamber to a substantially uniform magnetic field, to apply a permanent magnetic moment to the microbeads (25). At least one planar coil (22) and preferably an array of overlapping coils are located adjacent to the capillary chamber (14) for applying a complementary magnetic field on the microbeads parallel or antiparallel to said substantially uniform magnetic field, to drive the microbeads. An arrangement is provided for switching the current applied to the coil(s) (22) to invert the field produced thereby, to selectively apply an attractive or repulsive driving force on the microbeads (25). The device is usable to transport microbeads for performing chemical and biochemical reactions or assay, as is done for instance in clinical chemistry assays for medical diagnostic purposes.
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6.发明公开APPARATUS FOR MANIPULATING, MODIFYING AND CHARACTERIZING PARTICLES IN A MICRO CHANNEL 审中-公开VORRICHTUNG ZUR MANIPULATION，MODIFIKATION UND CHARAKTERISIERUNG VON PARTIKELN IN EINEM MIKROKANAL
公开(公告)号：EP1984723A2
公开(公告)日：2008-10-29
申请号：EP07705760.2
申请日：2007-02-01
IPC分类号： G01N15/12 , B01L3/00 , G01N27/447 , B03C5/00
CPC分类号： G01N15/12 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2200/12 , B01L2200/147 , B01L2300/0645 , B01L2300/0864 , B01L2400/0415 , B01L2400/0424 , B01L2400/086 , B03C5/026
摘要： Microfluidic system comprising a space for containing a liquid and at least one lateral chamber in communication with said space, said lateral chamber containing a metal electrode. The lateral chamber and the space are designed to be filled by the same or different liquid when the system is active.
摘要翻译： 微流体系统包括用于容纳液体的空间和与所述空间连通的至少一个横向室，所述侧室包含金属电极。 侧室和空间设计成当系统活动时由相同或不同的液体填充。
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公开(公告)号：EP1981642A1
公开(公告)日：2008-10-22
申请号：EP06707847.7
申请日：2006-01-26
发明人： LACHARME, Frédéric , GIJS, Martin
IPC分类号： B03C1/28
CPC分类号： B03C1/288 , B03C2201/26
摘要： An apparatus for retaining magnetic particles in self-assembled magnetic particle structures in a liquid flow, comprises a micro-channel (5) and magnets (1,2) for generating a substantially static magnetic field across the micro-channel (5) such that magnetic particles (12) suspended in a liquid in the micro-channel (5) form magnetic particle structures (15). The micro-channel (5) has along its length transverse large sections (8) alternating with narrow sections (9). The large sections (8) are periodically distributed along and on either side of the narrow sections (9) so that in use magnetic particle structures (15) form across the large sections (8) of the micro-channel (5), the magnetic particle structures being retained by engagement of end parts (18) of the magnetic particle structures in the large sections (8) of the cell or channel (5). The apparatus is useful in particular in life science, chemistry and microfiltration applications by flowing through the micro-channel (5) a fluid carrying molecules or particles to be captured, filtered or activated by the magnetic structures (15).
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8.发明公开Device for cell culture on deformable surfaces 审中-公开VorrichtungfürZellkulturen auf verformbarenOberflächen
公开(公告)号：EP1679366A1
公开(公告)日：2006-07-12
申请号：EP05100076.8
申请日：2005-01-07
发明人： Quinn, Thomas , Majd, Hicham
IPC分类号： C12M3/00
摘要： Device for the in vitro culture of cells comprising :
a planar deformable substrate (3) with a culture surface (4),
substrate deforming means for modifying the size of said culture surface (4), characterized by the fact that it furthermore comprises :
substrate holding elements (5) which are located near the periphery of said culture surface (4),
a frame (6,8) surrounding and directly or indirectly fixing said substrate holding elements (5), in such a way as to allow microscope viewing of the culture surface (4) and to avoid mechanical parts directly above or below the culture surface (4), said frame (6,8) being adapted to move said substrate holding elements (5) away from the center of said culture surface (4).摘要翻译： 用于体外培养细胞的装置包括：具有培养表面（4）的平面可变形基底（3），用于改变所述培养表面（4）尺寸的基底变形装置，其特征在于，其还包括：基底 位于所述培养表面（4）的周边附近的保持元件（5），围绕并直接或间接固定所述基板保持元件（5）的框架（6,8），以允许显微镜观察 培养表面（4）并且避免直接在培养表面（4）上方或下方的机械部分，所述框架（6,8）适于将所述基底保持元件（5）移动离开所述培养表面（4）的中心 ）。
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