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1.发明公开BIODEGRADABLE CROSS-LINKED CATIONIC MULTI-BLOCK COPOLYMERS FOR GENE DELIVERY AND METHODS OF MAKING THEREOF 审中-公开可生物降解，交联阳离子多嵌段共聚物基因传递及其制造方法
公开(公告)号：EP1807054A4
公开(公告)日：2008-07-23
申请号：EP05824081
申请日：2005-11-03
发明人： SLOBODKIN GREGORY , MATAR MAJED , FEWELL JASON , ANWER KHURSHEED
IPC分类号： A61K9/14
CPC分类号： C08G73/0206 , A61K47/34 , A61K48/00
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2.发明公开COMBINATION OF IMMUNO GENE THERAPY AND CHEMOTHERAPY FOR TREATMENT OF CANCER AND HYPERPROLIFERATIVE DISEASES 有权免疫基因疗法治疗癌症和疾病的过度增生疗法相结合，化疗后
公开(公告)号：EP1827101A2
公开(公告)日：2007-09-05
申请号：EP05851858.0
申请日：2005-11-17
IPC分类号： A01N43/04 , A61K31/70 , A61K39/395
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0085 , A61K31/17 , A61K31/28 , A61K31/337 , A61K31/4745 , A61K31/664 , A61K31/704 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K38/208 , A61K39/39558 , A61K47/10 , A61K47/6951 , A61K48/0041 , A61K48/005 , B82Y5/00 , C12N15/87 , A61K2300/00
摘要： Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
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3.发明公开A NOVEL CATIONIC LIPOPOLYMER AS A BIOCOMPATIBLE GENE DELIVERY AGENT 审中-公开NEW阳离子脂质聚合物作为生物相容性GENZUFUHRMITTEL
公开(公告)号：EP1680085A1
公开(公告)日：2006-07-19
申请号：EP03796920.1
申请日：2003-12-10
IPC分类号： A61K9/127
CPC分类号： C08G73/0206 , A61K9/1272 , A61K47/645 , A61K48/0041
摘要： A biodegradable cationic lipopolymer comprising a polyethylenimine (PEI), a lipid, and a biocompatible hydrophilic polymer, wherein 1) the lipid and the biocompatible hydrophilic polymer are directly linked to the PEI backbone or 2) the lipid is linked to the PEI backbone through the biocompatible hydrophilic polymer. The cationic lipopolymers of the present invention can be used for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.
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公开(公告)号：EP1320386A4
公开(公告)日：2005-01-26
申请号：EP01968346
申请日：2001-08-31
发明人： MAHATO RAM I , HAN SANG-OH , FURGESON DARIN Y
IPC分类号： C12N15/09 , A61K9/127 , A61K38/00 , A61K45/00 , A61K47/34 , A61K47/48 , A61K48/00 , C08G73/04 , C08L101/16 , A61K47/32 , A61K31/7105 , A61K31/711
CPC分类号： A61K9/1272 , A61K47/645
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5.发明公开A NOVEL CATIONIC LIPOPOLYMER AS A BIOCOMPATIBLE GENE DELIVERY AGENT 审中-公开NEW阳离子脂质聚合物作为生物相容性GENZUFUHRMITTEL
公开(公告)号：EP1680085A4
公开(公告)日：2006-10-18
申请号：EP03796920
申请日：2003-12-10
发明人： MAHATO RAM I , HAN SANG-OH , FURGESON DARIN Y , ANWER KHURSHEED
CPC分类号： C08G73/0206 , A61K9/1272 , A61K47/645 , A61K48/0041
摘要： A biodegradable cationic lipopolymer comprising a polyethylenimine (PEI), a lipid, and a biocompatible hydrophilic polymer, wherein 1) the lipid and the biocompatible hydrophilic polymer are directly linked to the PEI backbone or 2) the lipid is linked to the PEI backbone through the biocompatible hydrophilic polymer. The cationic lipopolymers of the present invention can be used for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.
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6.发明公开CELLULAR TARGETING POLY(ETHYLENE GLYCOL)-GRAFTED POLYMERIC GENE CARRIER 审中-公开聚（乙二醇）聚合物-GEPFROPFTER基因携带者FOR细胞靶向
公开(公告)号：EP1416969A2
公开(公告)日：2004-05-12
申请号：EP02753396.7
申请日：2002-07-19
发明人： SAGARA, Kazuyoshi
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/61 , A61K48/0041
摘要： Polymeric conjugates that can be used for targeted gene delivery comprising a poly(ethylene glycol) (PEG) grafted cationic polymer and a targeting moiety (TM), wherein 0.1 to 10 mole percent of the cationic groups of the cationic polymer are substituted with said PEG-TM.
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7.发明公开COMBINATION OF IMMUNO GENE THERAPY AND CHEMOTHERAPY FOR TREATMENT OF CANCER AND HYPERPROLIFERATIVE DISEASES 有权免疫基因疗法治疗癌症和疾病的过度增生疗法相结合，化疗后
公开(公告)号：EP1827101A4
公开(公告)日：2009-04-29
申请号：EP05851858
申请日：2005-11-17
发明人： FEWELL JASON G , MATAR MAJED , RICE JENNIFER , LEWIS DANNY H , ANWER KHURSHEED
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0085 , A61K31/17 , A61K31/28 , A61K31/337 , A61K31/4745 , A61K31/664 , A61K31/704 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K38/208 , A61K39/39558 , A61K47/10 , A61K47/6951 , A61K48/0041 , A61K48/005 , B82Y5/00 , C12N15/87 , A61K2300/00
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8.发明公开BIODEGRADABLE CROSS-LINKED CATIONIC MULTI-BLOCK COPOLYMERS FOR GENE DELIVERY AND METHODS OF MAKING THEREOF 审中-公开可生物降解，交联阳离子多嵌段共聚物基因传递及其制造方法
公开(公告)号：EP1807054A2
公开(公告)日：2007-07-18
申请号：EP05824081.3
申请日：2005-11-03
IPC分类号： A61K9/14
CPC分类号： C08G73/0206 , A61K47/34 , A61K48/00
摘要： A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks is linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.
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9.发明公开CELLULAR TARGETING POLY(ETHYLENE GLYCOL)-GRAFTED POLYMERIC GENE CARRIER 审中-公开聚（乙二醇）聚合物-GEPFROPFTER基因携带者FOR细胞靶向
公开(公告)号：EP1416969A4
公开(公告)日：2006-05-10
申请号：EP02753396
申请日：2002-07-19
发明人： SAGARA KAZUYOSHI
CPC分类号： C12N15/87 , A61K47/59 , A61K47/60 , A61K47/61 , A61K48/0041
摘要： Polymeric conjugates that can be used for targeted gene delivery comprising a poly(ethylene glycol) (PEG) grafted cationic polymer and a targeting moiety (TM), wherein 0.1 to 10 mole percent of the cationic groups of the cationic polymer are substituted with said PEG-TM.
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10.发明公开BIODEGRADABLE CATIONIC COPOLYMERS OF POLY(ALKYLENIMINE) AND POLY(ETHYLENE GLYCOL) FOR THE DELIVERY OF BIOACTIVE AGENTS 审中-公开生物降解的阳离子聚（亚烷基亚胺） - 和聚（乙二醇）共聚物TO MAKE生物活性剂
公开(公告)号：EP1365716A1
公开(公告)日：2003-12-03
申请号：EP02720996.4
申请日：2002-02-14
发明人： AHN, Cheol-Hee , KIM, Sung, Wan
CPC分类号： A61K9/5146 , A61K47/59 , A61K47/593 , A61K47/595 , A61K47/60 , Y10S977/773 , Y10S977/906
摘要： A biodegradable, novel cationic copolymer comprising a poly(alkylenimine)(PAI), a hydrophilic polymer, and a biodegradable linker, wherein the biodegradable linker covalently links the PAI and the hydrophilic polymer. The biodegradable cationic copolymers in the present invention can be used in drug delivery and are especially useful for delivery of a nucleic acid or any anionic bioactive agent to various organs and tissues after local or systemic administration.
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