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公开(公告)号：EP2336764A1
公开(公告)日：2011-06-22
申请号：EP09811272.5
申请日：2009-09-01
发明人： ZHOU, Xiaojing , UZU, Hideyuki
CPC分类号： G01N30/24 , G01N30/6047
摘要： A liquid chromatograph provided here is adapted to enable the lengths of tubings for connecting the respective constituent elements thereof to be minimized by making the positions of the respective constituent elements including a detector and a column movable and adjustable in order to reduce the dead volume in a liquid chromatograph system in plumbing and increase the analytical precision through prevention of diffusion of samples and rapid sending of a mixed liquid solvent. Furthermore, in order to prevent cross-contamination due to residues of samples and cleaning liquid in a flow channel of the liquid chromatograph system, an injection port in which a needle can be inserted is so provided as to communicate directly with a flow channel of an injection valve.
摘要翻译： 这里提供的液相色谱仪适用于通过使包括检测器和柱的各个组成元件的位置可移动和可调整以使得用于连接各个组成元件的管的长度最小化，以便减小 通过防止样品扩散和快速输送混合液体溶剂来提高分析精度。 此外，为了防止由于液体色谱系统的流路中的样品和清洗液的残留物引起的交叉污染，设置了可供针插入的注射口，以直接与液体流路的流路 喷射阀。
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2.发明公开DIRECT HEATING TUBE AND METHOD OF HEATING FLUID USING THE SAME 有权DIREKTHEIZROHR UND VERFAHREN ZUMERWÄRMENEINES FLUIDS UNTER VERWENDUNG DESSELBEN
公开(公告)号：EP1719958A1
公开(公告)日：2006-11-08
申请号：EP04710997.0
申请日：2004-02-13
IPC分类号： F24H1/10
摘要： Provided is a direct heating tube which has a sufficient heating rate and a sufficient cooling rate, and has no cold spots therein, making it possible to ensure a uniform temperature distribution in the whole part thereof or a temperature distribution having a desired temperature gradient, and making it possible to keep constant the temperature of a fluid which is caused to flow through the tube or to give a desired change to the temperature of the fluid. Provided also is a direct heating tube which does not exert an adverse influence on devices near the tube, such as a detector and an oven, even by heating the tube. In a desired portion of the tube to be heated, a second heated tube connected to a first heated tube is provided outside the first heated tube, and an electrode portion is connected to the second heated tube.
摘要翻译： 提供一种具有足够的加热速率和足够的冷却速度的直接加热管，并且其中没有冷点，使得可以确保其整个部分的温度分布均匀或具有期望的温度梯度的温度分布，以及 使得可以使流过管的流体的温度保持恒定，或者使流体的温度达到期望的变化。 还提供了即使通过加热管也不会对诸如检测器和烘箱的管附近的装置产生不利影响的直接加热管。 在要加热的管的期望部分中，连接到第一加热管的第二加热管设置在第一加热管的外部，并且电极部分连接到第二加热管。
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公开(公告)号：EP2589946A2
公开(公告)日：2013-05-08
申请号：EP12183249.7
申请日：2012-09-06
CPC分类号： G01M3/18 , G01M3/16 , G01N33/0022
摘要： A gas-leak detector includes a suction pump that sucks sample gas and reference gas, two gas detection sensors, and a cell block having a cell therein. The cell receives the gasses and has two suction-gas introduction channels and a single gas discharge channel opening thereinto. The gas-leak detector detects a gas leak on the basis of outputs from the sensors. The introduction channels and the discharge channel open into the cell at a first one of opposing surfaces of the cell, the opening of the discharge channel being arranged between the openings of the two introduction channels. The sensors are on the same plane as a second one of the opposing surfaces and are arranged between the opening of the discharge channel and the openings of the introduction channels. The suction pump is arranged on the cell block and communicates with the opening of the discharge channel.
摘要翻译： 气体泄漏检测器包括抽吸气体和参考气体的抽吸泵，两个气体检测传感器和其中具有电池的电池块。 电池接收气体并具有两个吸气引入通道和一个单独的气体排放通道。 气体泄漏检测器基于来自传感器的输出来检测气体泄漏。 引入通道和排出通道在电池的相对表面的第一个相对表面处开放到电池中，放电通道的开口布置在两个引入通道的开口之间。 传感器位于与相对表面中的第二个相同的平面上，并且布置在排出通道的开口和引入通道的开口之间。 抽吸泵布置在电池块上并与排放通道的开口连通。
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4.发明公开METHOD FOR SILICA MONOLITH CLADDING AND SEPARATION MEDIUM 审中-公开VERFAHREN ZURUMHÜLLUNGVON硅氧化物在TRENNMEDIUM
公开(公告)号：EP2246299A1
公开(公告)日：2010-11-03
申请号：EP08710958.3
申请日：2008-02-01
发明人： MIYAZAKI, Shota , TERASHIMA, Hiroyuki , NYUDO, Masahiko , OHIRA, Masayoshi , MORISATO, Kei , FURUNO, Masahiro
CPC分类号： B01D15/22 , B01D15/20 , B01J20/103 , B01J20/28042 , B01J20/283 , B01J20/3257 , B01J2220/54 , B01J2220/82 , B01J2220/825 , G01N30/50 , G01N30/6052 , G01N2030/528
摘要： To use a monolithic silica body in chromatography with a HPLC column or a GC column and to simplify the use thereof as a separation medium, it is intended to provide a method of cladding a main body of a monolithic adsorbent or separating agent with glass so as to protect the outer surface, and to provide a separation medium prepared by the method. To this end, a monolithic silica body alone is formed by molding, and the molding is coated with a glass body; and then the glass body and the monolithic silica body are fused and integrated at the melting temperature of the glass body at an appropriate pressure. The surface of the resulting monolithic silica body clad with glass is strongly protected by the glass, and the homogeneity of the interior of the monolithic silica body is maintained, and thus uniform flow of a sample solution ensures analytical accuracy.
摘要翻译： 为了在使用HPLC柱或GC色谱柱的色谱法中使用整体式二氧化硅体，并且为了简化其作为分离介质的用途，旨在提供一种用玻璃包覆整体式吸附剂或分离剂的主体的方法，以便 以保护外表面，并提供通过该方法制备的分离介质。 为此，单独的整体式二氧化硅体通过成型而形成，成型用玻璃体涂布; 然后玻璃体和整体式二氧化硅体在玻璃体的熔融温度下以适当的压力熔融并整合。 用玻璃覆盖的所得整体二氧化硅体的表面被玻璃强烈保护，并且保持了整体二氧化硅体内部的均匀性，因此样品溶液的均匀流动确保了分析精度。
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5.发明公开METHOD AND APPARATUS FOR ANALYZING AMINO ACID, PEPTIDE, PROTEIN, SACCHARIDE OR LIPID 审中-公开VERFAHREN UND VORRICHTUNG ZURAMINOSÄURE-，PEPTID-，PROTEIN-，SACCHARID-ODER LIPIDANALSE
公开(公告)号：EP1477800A1
公开(公告)日：2004-11-17
申请号：EP03703116.8
申请日：2003-01-31
发明人： KURODA, Ikuma, c/o GL Sciences Incorporated , TAKAHASHI, Kouji, c/o GL Sciences Incorporated , NAKAMURA, Hiroshi
CPC分类号： G01N30/88 , B01J20/0211 , B01J20/06 , B01J20/282 , B01J20/287 , B01J2220/54 , C07K1/20 , G01N30/02 , G01N30/08 , G01N30/34 , G01N30/466 , G01N30/468 , G01N30/6004 , G01N2030/085 , G01N2030/8813 , G01N2030/8818 , G01N2030/8831 , G01N2030/8836 , B01D15/325
摘要： The present invention aims to easily and simply perform selective detection/identification, extraction, separation, and purification of a phosphorylated amino acid, phosphorylated peptide, or phosphorylated protein from a sample containing any one of them, comprising the steps of: retaining the phosphorylated amino acid, phosphorylated peptide, or phosphorylated protein in a pretreatment column by passing the sample containing the phosphorylated amino acid, phosphorylated peptide, or phosphorylated protein through a reversed phase HPLC column having a titanium dioxide column as the pretreatment column and retaining a non-phosphorylated amino acid, peptide, or protein in the reverse phase HPLC column; eluting the non-phosphorylated amino acid, peptide, or protein that is retained in the reversed phase HPLC column; eluting the phosphorylated amino acid, phosphorylated peptide, or phosphorylated protein retained in the pretreatment column with buffer; and detecting it.
摘要翻译： 本发明的目的是容易且简单地从含有其中任何一种的样品中进行磷酸化氨基酸，磷酸化肽或磷酸化蛋白质的选择性检测/鉴定，提取，分离和纯化，包括以下步骤：保持磷酸化氨基 通过使含有磷酸化氨基酸，磷酸化肽或磷酸化蛋白质的样品通过具有二氧化钛柱的反相HPLC柱作为预处理柱，并保留非磷酸化氨基的预处理柱中的酸，磷酸化肽或磷酸化蛋白 酸，肽或蛋白质; 洗脱保留在反相HPLC柱中的非磷酸化氨基酸，肽或蛋白质; 用缓冲液洗脱预处理柱中保留的磷酸化氨基酸，磷酸化肽或磷酸化蛋白质; 并进行检测。
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6.发明公开METHOD FOR COLLECTING SAMPLE AND DEVICE FOR COLLECTING SAME 审中-公开VERFAHREN ZUR ENTNAHME EINER PROBE UND VORRICHTUNG ZU DEREN ENTNAHME
公开(公告)号：EP2518489A1
公开(公告)日：2012-10-31
申请号：EP10845684.9
申请日：2010-02-12
CPC分类号： G01N30/12 , F25B9/14 , G01N1/40 , G01N30/465 , G01N30/7206 , G01N2001/4033 , G01N2030/085 , G01N2030/121 , G01N2030/122 , G01N2030/128 , G01N2030/884
摘要： An object of the present invention is to provide a sample trapping method and a sample trapping apparatus. The present invention is suitable, for example, for analysis by a gas chromatograph-mass spectrometer. A sample is not cooled by a refrigerant such as liquid nitrogen in the present invention. Instead, a cold storage refrigerator such as a Stirling refrigerator or a Gifford-McMahon refrigerator is used. As a result, the operability is improved and the running cost is reduced. In addition, a refrigerant pipe is not used in the present invention. It is thus possible to reduce the size and weight of the apparatus, to improve the efficiency and accuracy for cooling the sample, and to rapidly cool the sample. Furthermore, it is possible to rapidly heat the sample. As a result, the trapped sample is instantaneously desorbed. Therefore, the present invention makes it possible to achieve cryofocusing in gas chromatography (particularly in high-speed gas chromatography).
Solutions of the present invention include a sample trapping method using a sample conduit for trapping a gas sample by cooling or desorbing the gas sample by heating. The solutions further include cooling a sample conduit (17) by arranging the sample conduit (17) in the vicinity of, or bringing the sample conduit (17) into contact with, a cooling part of a cooling device (20) based on a cold storage refrigerator.摘要翻译： 本发明的目的是提供一种样品捕集方法和一种样品捕集装置。 本发明适用于例如气相色谱 - 质谱仪的分析。 在本发明中，样品不被诸如液氮的制冷剂冷却。 相反，使用诸如斯特林冰箱或吉福德 - 麦克马洪冰箱的冷藏冰箱。 结果，可操作性提高，运行成本降低。 此外，在本发明中不使用制冷剂管。 因此，可以减小设备的尺寸和重量，提高冷却样品的效率和精度，并快速冷却样品。 此外，可以快速加热样品。 结果，捕获的样品瞬间解吸。 因此，本发明可以在气相色谱法（特别是高速气相色谱法）中实现冷凝。 本发明的解决方案包括使用样品导管用于通过加热冷却或解吸气体样品来捕集气体样品的样品捕集方法。 解决方案还包括通过将样品管道（17）布置在基于冷的冷却装置（20）的冷却部分附近或使样品管道（17）接触的方式来冷却样品管道（17） 存储冰箱
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公开(公告)号：EP1382963B1
公开(公告)日：2008-09-03
申请号：EP02722709.9
申请日：2002-04-19
发明人： HIRAMATSU, Yuka, c/o GL Sciences Incorporated , YAMASAKI, Kazuhiko, c/o GL Sciences Incorporated , FURUNO, Masahiro, c/o GL Sciences Incorporated
CPC分类号： G01N1/405 , B01D15/00 , B01D15/08 , B01J20/28042 , B01J20/28054 , B01J20/28092 , B01J2220/64 , B01L3/022 , B01L3/0275 , B01L2200/0631 , G01N1/40 , G01N30/18 , G01N2030/009
摘要： A method for extracting a component in a sample in solid phase in order to provide means effective for pretreating a sample being introduced to a chromatograph. The method comprises a step for providing a needle at the forward end of a syringe having a tube and a plunger slidable in the tube, forming a porous body of so-called monolithic structure in the needle at least over a proper length and the entire diameter and then inserting the needle into a sample, a step for passing the sample through the needle and holding a target component in the porous body, and a step for separating the target component from the interior of the porous body.
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公开(公告)号：EP1452864A1
公开(公告)日：2004-09-01
申请号：EP02783671.7
申请日：2002-11-28
CPC分类号： G01N30/60 , G01N30/6004 , G01N30/6047
摘要： In the field of substance separation which uses the flow of a fluid, it is necessary to reduce the inside diameter of a separation column in order to meet the tendency to reduce the volume of an organic solvent used. The smaller the volume of a target sample which is caused to flow, the higher the concentration of the target sample, thereby permitting a high-sensitivity analysis. For this purpose, it is necessary to reduce the diameter of a separation column. Therefore, the manufacturing of such a separation column is difficult and besides the separation column becomes apt to fracture. Therefore, the separation column is fabricated as a double-wall tube constituted by an outer tube and an inner tube in such a manner that the outer tube is separated so as to be freely inserted and extracted. Furthermore, a union is fitted to the end of the outer tube by use of a screw thereby to prevent torsions between the outer tube and the inner tube and strains and, at the same time, to eliminate a space for a dead volume.
摘要翻译： 在使用流体的物质分离领域中，为了满足减少所用有机溶剂体积的倾向，必须减小分离塔的内径。 导致流动的目标样品的体积越小，目标样品的浓度越高，从而允许高灵敏度分析。 为此，需要减小分离柱的直径。 因此，这种分离塔的制造困难，而且分离塔容易断裂。 因此，分离柱被制造为由外管和内管构成的双壁管，使得外管被分离以便自由地插拔。 此外，通过使用螺钉将联接件装配到外管的端部，从而防止外管和内管之间的扭转并且同时消除死体积的空间。
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公开(公告)号：EP1375673A1
公开(公告)日：2004-01-02
申请号：EP02705325.5
申请日：2002-03-19
发明人： KONDO, Toshihiko , ABE, Shuzo c/o GL Sciences Inc. Technical Center , SHIKAMA, Nobuyosi c/o GL Sciences Inc. Techn.Ctr. , SHINTANI, Yukihiro c/o GL Sciences Inc.Techn.Ctr.
CPC分类号： C12Q1/6837 , B01L7/525 , B01L7/54 , B01L2300/0838 , B01L2300/087 , B01L2300/1827 , B01L2400/0487 , C12Q2565/137 , C12Q2527/101
摘要： This invention relates to a method for analyzing a gene and an analysis device thereof which are suited to be used, for example, as a fully automatic gene analysis device or a fully automatic gene diagnostic device which can be simplified in structure, made compact in size and light in weight, and manufactured at a low cost and in which detection of various kinds of DNA can be conducted rapidly and with precision and analysis of a plurality of genes can be made simultaneously from different kinds of samples by restraining, as much as possible, the use of a valve in an analytic system, thereby preventing admixture of cross contamination.
It relates to a gene analysis method comprising the steps of extracting a target nucleic acid from a biological sample (23) and amplifying a target DNA, thereafter, introducing a reaction eluent (L) containing a predetermined DNA into a stationary-phase DNA probe (53) having a predetermined temperature and arranged in series or in parallel and separating a DNA complementary to the stationary-phase DNA probe (53).
The above-mentioned gene analysis method comprises a plurality of stationary-phase DNA probes (64 through 66) at least a part of which can be set to a temperature for forming a double strand of DNA to be tested and a reaction eluent containing the same or different kinds of DNA which have been amplified, is introduced into the stationary-phase DNA probes (64 through 66).摘要翻译： 分析基因的方法及其分析装置本发明涉及适用于例如全自动基因分析装置或全自动基因诊断装置的基因分析方法及分析装置，其结构简单，尺寸紧凑 重量轻，制造成本低，并且可以迅速并且精确地进行各种DNA的检测，并且可以通过尽可能地抑制不同种类的样品同时分析多种基因 ，在分析系统中使用阀，从而防止交叉污染的混合。 本发明涉及一种基因分析方法，其包括从生物样品（23）中提取靶核酸并扩增靶DNA，然后将含有预定DNA的反应洗脱液（L）导入固定相DNA探针（ 53）具有预定温度并串联或并联排列并分离与固定相DNA探针（53）互补的DNA。 上述基因分析方法包括多个固定相DNA探针（64至66），它们的至少一部分可以设定为用于形成待测试DNA双链的温度以及含有该探针的反应洗脱液 或已扩增的不同种类的DNA导入固定相DNA探针（64至66）。
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公开(公告)号：EP2589946B1
公开(公告)日：2018-08-01
申请号：EP12183249.7
申请日：2012-09-06
CPC分类号： G01M3/18 , G01M3/16 , G01N33/0022
摘要： A gas-leak detector includes a suction pump that sucks sample gas and reference gas, two gas detection sensors, and a cell block having a cell therein. The cell receives the gasses and has two suction-gas introduction channels and a single gas discharge channel opening thereinto. The gas-leak detector detects a gas leak on the basis of outputs from the sensors. The introduction channels and the discharge channel open into the cell at a first one of opposing surfaces of the cell, the opening of the discharge channel being arranged between the openings of the two introduction channels. The sensors are on the same plane as a second one of the opposing surfaces and are arranged between the opening of the discharge channel and the openings of the introduction channels. The suction pump is arranged on the cell block and communicates with the opening of the discharge channel.
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