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1.发明公开METHOD FOR MANUFACTURING NITROBENZENE COMPOUND 有权VERFAHREN ZUR HERSTELLUNG EINER NITROBENZOLVERBINDUNG
公开(公告)号：EP3015451A1
公开(公告)日：2016-05-04
申请号：EP14817123.4
申请日：2014-06-03
发明人： IKUMI, Akiko , NAKAMURA, Takayuki
IPC分类号： C07C201/06 , C07C205/12 , C07C205/58 , C07B61/00
CPC分类号： C07C201/10 , C07C205/58 , C07C205/12
摘要： The purpose of the present invention is to provide an economically favorable, industrialization-suitable method for manufacturing nitrobenzene compounds of general formula (1). A method for manufacturing nitrobenzene compounds of general formula (1):
(in the formula, R 1 represents a halogen atom; R 2 , R 3 , and R 4 represent a hydrogen atom, etc.; and R 5 represents a halogen atom or alkoxy carbonyl group), the method including the following processes: (i) a process for reacting aniline compounds of general formula (2):
(in the formula, R 1 , R 2 , R 3 , R 4 , and R 5 are as previously defined.) in the presence of a metal salt of nitrous acid and an acid, and (ii) a process for reacting the product of process (i) in the presence of a metal salt of nitrous acid and a copper compound; and the total amount of water used in process (ii) being 1.2-2.2 L (liters) with respect to one mole of the compound of general formula (2).摘要翻译： 本发明的目的是提供一种经济上有利的工业化合适的制备通式（1）的硝基苯化合物的方法。 制备通式（1）的硝基苯化合物的方法：（式中，R 1表示卤素原子; R 2，R 3和R 4表示氢原子等; R 5表示卤素原子或 烷氧基羰基），该方法包括以下方法：（i）使通式（2）的苯胺化合物反应的方法：（式中，R 1，R 2，R 3，R 4和R 5为 （ii）在亚硝酸金属盐和铜化合物的存在下使方法（i）的产物反应的方法;和（ii）使方法（i）的产物在亚硝酸金属盐和铜化合物的存在下反应的方法; 并且相对于1摩尔通式（2）的化合物，方法（ii）中使用的水的总量为1.2-2.2L（升）。
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公开(公告)号：EP2792242A1
公开(公告)日：2014-10-22
申请号：EP12853240.5
申请日：2012-11-19
发明人： FUKUMOTO, Shunichirou , SHIKAMA, Daisuke , NAGATA, Toshihiro , KATO, Katsuya , KAWAMOTO, Kei , KOMATSU, Masaaki , MATSUDA, Takeshi , ITO, Seisuke
IPC分类号： A01N37/34 , A01P7/02 , A01P7/04 , C07C259/14
CPC分类号： A01N37/52 , A01N37/18 , C07C259/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14
摘要： [Problem] The present invention provides a glyoxime derivative displaying excellent pesticidal effect or a salt thereof and a pesticide containing the same as an active ingredient.
[Solution] This pesticide is characterized by containing as an active ingredient, a glyoxime derivative expressed by the general formula [I] (in which the formula, X represents a cyano group or a carbamoyl group, R 1 represents a C 1 ∼C 8 alkyl group, a C 3 ∼C 6 cycloalkyl C 1 ∼C 6 alkyl group, etc, and R 2 represents a hydrogen atom, a C 1 ∼C 8 alkyl group, , a C 3 ~C 6 cycloalkyl C 1 ∼C 6 alkyl group, etc.) or an agriculturally acceptable salt thereof.摘要翻译： 本发明提供显示优异的杀虫效果的乙二肟衍生物或其盐及含有其的农药作为有效成分。 该农药的特征在于，作为有效成分含有通式[I]所示的乙二肟衍生物（式中，X表示氰基或氨基甲酰基，R 1表示碳原子数1〜8的烷基， C 3〜C 6环烷基C 1〜C 6烷基等，R 2表示氢原子，C 1〜C 8烷基，C 3〜C 6环烷基C 1〜C 6烷基等）或其农业上可接受的盐。
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公开(公告)号：EP1072580B1
公开(公告)日：2010-12-01
申请号：EP99917085.5
申请日：1999-04-21
IPC分类号： C07C51/363 , C07C57/30
CPC分类号： C07C51/363 , C07C57/58
摘要： A process for producing chloromethylphenylacetic acid represented by formula (II) which comprises reacting methylphenylacetic acid represented by formula (I) with chlorine gas in an inert solvent under photoirradiation or in the presence of a radical initiator. According to this process, the methyl group of the methylphenylacetic acid can be chlorinated without resort to toxic sulfuryl chloride as a chlorinating agent and thus highly pure chloromethylphenylacetic acid can be produced at a high yield while inhibiting the formation of by-products such as the dichloro compound and the α-chloro compound.
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公开(公告)号：EP2226312A1
公开(公告)日：2010-09-08
申请号：EP08854991.0
申请日：2008-11-28
发明人： KAWAZOE, Kentaro
IPC分类号： C07C319/02 , C07C303/22 , C07C309/86 , C07C323/09 , C07B61/00
CPC分类号： C07C319/02 , C07C303/22 , C07C309/86 , C07C323/34
摘要： Disclosed is a simple method for efficiently producing a 3-mercaptoaniline compound which is known as an intermediate for a 3-(1H-1,2,4-triazol-1-yl)phenylsulfide derivative that is useful as a pesticide and the like. Also disclosed is a method for producing a compound which can be a raw material to be used in the method for producing a 3-mercaptoaniline compound. Specifically disclosed is a method for producing a 3-mercaptoaniline compound represented by general formula (2), which is characterized in that a nitro group and a chlorosulfonyl group of a 3-nitrobenzenesulfonyl chloride compound represented by general formula (1) are reduced in the presence of an acid catalyst. Also specifically disclosed is a method for producing a compound which can be a raw material to be used in the method for producing a 3-mercaptoaniline compound. (1) (In the general formula (1), R represents an alkyl group or a cyclic alkyl group, and X represents a halogen atom.) (2) (In the general formula (2), R and X are as defined above.)
摘要翻译： 公开了一种用于有效地生产其被称为中间因为这是作为农药等有用的3-（1H-1,2,4-三唑-1-基）苯硫醚衍生物的3-巯基化合物的简单方法。 还公开了制备可用作制备3-巯基苯胺化合物的方法中的原料的化合物的方法。 具体公开的是用于生产由通式（2），其特征在于，硝基和由通式表示的氯磺酰基的3-硝基苯磺酰氯化合物的表示的3-巯基苯胺化合物的方法（1）在所述经还原 存在酸催化剂。 还具体公开了制备可用作3-巯基苯胺化合物的制备方法中的原料的化合物的方法。 （1）（通式（1）中，R表示烷基或环状烷基，X表示卤素原子。）（2）（通式（2）中，R和X如上所述 。）
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公开(公告)号：EP1586552B1
公开(公告)日：2010-08-25
申请号：EP03768351.3
申请日：2003-12-26
发明人： ITO, Akinori, Ihara Chemical Industry Co. Ltd , OHASHI, Hideaki , MAGARIBUCHI, Kagetomo, Ihara Chemical Ind. Co. Ltd
IPC分类号： C07C209/62 , C07C211/29 , C07C231/12 , C07C233/31 , C07C269/04 , C07C271/18
CPC分类号： C07C231/12 , C07C209/62 , C07C211/29 , C07C233/31 , C07C269/04 , C07C271/18
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6.发明公开Isoxazoline derivative and herbicide comprising the same as active ingredient 有权Isoxazolinderivat und dieses als Wirkstoff enthaltendes Herbizid
公开(公告)号：EP2186410A1
公开(公告)日：2010-05-19
申请号：EP10000323.5
申请日：2002-02-07
发明人： Nakatani, Masao , Kugo, Ryotaro , Miyazaki, Masahiro , Kaku, Koichiro , Fujinami, Makoto , Ueno, Ryohei , Takahashi, Satoru
IPC分类号： A01N43/80 , A01N43/82 , C07D413/12 , C07D261/04 , C07D261/08 , C07D261/20 , C07D413/14 , C07D417/12 , C07D498/04
CPC分类号： C07D261/10 , A01N43/80 , A01N43/90 , A01N47/38 , C07D261/04 , C07D261/08 , C07D261/20 , C07D413/12 , C07D413/14 , C07D417/12
摘要： An isoxazoline derivative which is represented by the general formula: [I] wherein R 1 and R 2 represent an alkyl group and may be the same or different, R 3 , R 4 , R 5 and R 6 represent a hydrogen atom, Y is a thiophen-3-yl group and the thiophehe ring is substituted with the substituent group α at the 2- and 4-positions; or a isoxazol-4-yl group and the isoxazole ring is substituted with the substituent group α at the 3- and 5-positions; or a isothiazol-4-yl group and the isothiazole ring is substituted with the substituent group α at the 3- and 5-positions; or a pyridine-3-yl group and the pyridine ring is substituted with the substituent group α at the 2- and 4-positions; or a pyrimidin-5-yl group and the pyrimidine ring is substituted with the substituent group α at the 4- and 6-positions, and n represents an integer of 0 to 2. The isoxazoline derivative exhibits excellent herbicidal effect and selectivity between a crop and a weed.
摘要翻译： 由通式[I]表示的异恶唑啉衍生物，其中R 1和R 2表示烷基，可以相同或不同，R 3，R 4，R 5和R 6表示氢原子，Y为 噻吩-3-基和硫代硫醚环在2-和4-位取代有取代基±， 或异恶唑-4-基，异唑环在3-和5-位被取代基±±取代; 或异噻唑-4-基，并且异噻唑环在3-和5-位被取代基±±取代; 或吡啶-3-基，吡啶环在2-位和4-位取代有取代基±， 或嘧啶-5-基，并且嘧啶环在4-和6-位被取代基±取代，n表示0至2的整数。异恶唑啉衍生物在作物之间显示出优异的除草效果和选择性 和杂草。
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公开(公告)号：EP1810957A1
公开(公告)日：2007-07-25
申请号：EP05805558.3
申请日：2005-11-07
发明人： KAWAZOE, Kentaro Ihara Chemical Industry Co., Ltd. , YOSHIDA, Yasuoo Ihara Chemical Industry Co., Ltd.
CPC分类号： C07C37/07 , C07C39/15 , C07C39/367 , C07C41/26 , C07C45/74 , C07C49/683 , C07C49/697 , C07C49/753 , C07C43/23
摘要： [Task]
Provide a process for producing a 2-benzylphenol compound easily, efficiently and selectively.
[Means for Achievement]
A process for producing a 2-benzylphenol compound represented by the following general formula (2)
(in the formula, R 1 , R 2 , R 3 and R 4 may be the same or different and are each independently hydrogen atom, alkyl group or the like; and R 5 , R 6 , R 7 , R 8 and R 9 may be the same or different and are each independently hydrogen atom, alkyl group or the like), characterized by reacting, in the presence of a dehydrogenating agent, a benzylidenecyclohexanone compound represented by the following general formula (1)
(in the formula, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 have the same definitions as given above).
[Effect]
A 2-benzylphenol compound substantially free from isomers can be produced from a benzylidenecyclohexanone compound (an easily obtainable raw material) selectively, efficiently and in a simple operation, under mild conditions without using any special reactor.摘要翻译： [任务]提供一种容易，有效和选择性地生产2-苄基苯酚化合物的方法。 [用于实现的方式]制备由以下通式（2）表示的2-苄基苯酚化合物的方法（式中，R 1，R 2，R 3和R 4可以相同或不同，并且各自独立地为氢原子，烷基 等等;并且R 5，R 6，R 7，R 8和R 9可以相同或不同，各自独立地为氢原子，烷基等），其特征在于在脱氢剂的存在下，使所代表的亚苄基环己酮化合物 由下述通式（1）（式中，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9与上述定义相同。 [效果]在不使用任何特殊反应器的情况下，可以在温和条件下选择性地，有效地并且以简单的操作从亚苄基环己酮化合物（容易获得的原料）制备基本上不含异构体的2-苄基苯酚化合物。
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公开(公告)号：EP1767528A1
公开(公告)日：2007-03-28
申请号：EP05728918.3
申请日：2005-03-31
IPC分类号： C07D231/20 , C07D413/12
CPC分类号： C07D231/30
摘要： A pyrazole compound represented by general formula (1) is reacted with a sulfur compound represented by general formula (2) in the presence of a base and formaldehyde, to thereby produce a 5-hydroxy-4-thiomethylpyrazole compound represented by general formula (3). The 5-hydroxy-4-thiomethylpyrazole compound may easily be produced in a good yield, by using such a process. Further, this process may easily provide the 5-hydroxy-4-thiomethylpyrazole compound under a mild condition in a single step, without using a special apparatus, an expensive catalyst, or a transition metal, etc. In addition, this process may be conducted substantially without producing a harmful waste which can be derived from a catalyst, etc., and therefore this process is friendly to the environment and industrially valuable.
摘要翻译： 通式（1）表示的吡唑化合物与通式（2）表示的硫化合物在碱和甲醛的存在下反应，由此制备通式（3）表示的5-羟基-4-硫代甲基吡唑化合物 ）。 通过使用这种方法，5-羟基-4-硫代甲基吡唑化合物可以容易地以高产率生产。 此外，该方法可以容易地在单一步骤中在温和条件下提供5-羟基-4-硫代甲基吡唑化合物，而无需使用特殊装置，昂贵的催化剂或过渡金属等。另外，该过程可以进行 基本上不会产生可由催化剂等产生的有害废物，因此该工艺对环境友好且具有工业价值。
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公开(公告)号：EP1188752B1
公开(公告)日：2006-11-29
申请号：EP01917777.3
申请日：2001-04-02
IPC分类号： C07D277/64
CPC分类号： C07D277/64 , C07D277/82
摘要： A process for producing a substituted alkylamine derivative represented by general formula (3) or an acid addition salt thereof which comprises adding a salt of a 2-aminothiophenol derivative represented by general formula (1) to an acid, adjusting the pH of the mixture to 6 or lower to thereby convert the salt into a free form, and then reacting the free-form compound with an amino acid N-carboxyanhydride represented by general formula (2). In the formulae, X, n, R1, and R2 are the same as defined in the claims.
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公开(公告)号：EP1026163B1
公开(公告)日：2006-03-22
申请号：EP98944223.1
申请日：1998-09-24
发明人： UMEZU, Kazuto, Ihara Chemical Industry Co., Ltd , TANIGUCHI, Shuji, Ihara Chemical Industry Co., Ltd , OGAWA, Mahito, Ihara Chemical Industry Co., Ltd , HIYOSHI, Hidetaka, Ihara Chem. Industry Co., Ltd
IPC分类号： C07D277/64
CPC分类号： C07D277/64
摘要： A process for producing substituted alkylamines of general formula (3) or salts thereof, characterized by reacting a metal salt of a 2-aminothiophenol derivative of general formula (1) with an amino acid N-carboxy anhydride of general formula (2) and cyclizing the obtained product under acidic conditions. By this process, substituted alkylamines typified by 1-(2-benzothiazolyl)alkylamines and salts thereof can be produced in high yields from 2-aminothiophenol derivatives on an industrial scale while keeping excellent handling properties. Even when the intended substituted alkylamine is an optically active compound, the intended product can be produced without reducing the optical purity of the optically active starting material.
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