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23 条记录 (耗时 0.017 秒)

    PREVENTIVES OR REMEDIES FOR HEPATOPATHY
    2.
    发明授权
    PREVENTIVES OR REMEDIES FOR HEPATOPATHY 有权
    手段预防和愈合肝病

    公开(公告)号：EP1632244B1

    公开(公告)日：2012-03-21

    申请号：EP04730725.1

    申请日：2004-04-30

    申请人： Kangawa, Kenji

    发明人： KANGAWA, Kenji ,  HOSODA, Hiroshi

    IPC分类号： A61K38/10 ,  A61K38/16 ,  A61P1/16

    CPC分类号： A61K31/00 ,  A61K38/25

    摘要： A preventive or a remedy for hepatopathy containing, as the active ingredient, a derivative of a polypeptide which exhibits an activity of binding to growth hormone secretion-inducer receptor and thus elevating intracellular calcium ion concentration and has an amino acid sequence selected from the group consisting of the amino acid sequences represented by SEQ ID NOS:1 to 22 or an amino acid sequence derived from such an amino acid sequence by the deletion, substitution or addition of one to several amino acids other than the amino acid residues at the 1- to 4-positions in the amino terminal side or a pharmacologically acceptable salt of the same. This preventive or remedy for hepatopathy is useful as a drug suitable for treating or preventing liver diseases such as hepatitis, hepatic cirrhosis and hepatic insufficiency. This preventive or remedy for hepatopathy is also useful as a drug for promoting liver regeneration or liver function recovery after hepatoctomy.

    PROCESS FOR PRODUCING MODIFIED PEPTIDE
    8.
    发明公开
    PROCESS FOR PRODUCING MODIFIED PEPTIDE 有权
    用于生产修饰肽

    公开(公告)号：EP1493747A1

    公开(公告)日：2005-01-05

    申请号：EP03723102.4

    申请日：2003-04-10

    申请人： Daiichi Suntory Pharma Co., Ltd. ,  Kangawa, Kenji

    发明人： MINAMITAKE, Yoshiharu ,  MATSUMOTO, Masaru ,  MAKINO, Tomohiro

    IPC分类号： C07K1/04 ,  C07K1/06 ,  C07K14/46 ,  C07K14/465 ,  C07K9/00

    CPC分类号： C07K14/60 ,  C07K14/465

    摘要： The present invention is a method for producing a peptide or a protein in which a side chain contains a modified amino acid residue, which comprises chemically producing a peptide fragment containing an amino acid residue having a modified side chain using an weak acid-cleavable resin, producing a peptide fragment containing no amino acid residue having a modified side chain using a genetic recombination method or/and an enzymatic method, and condensing the resulting two kinds of peptide fragments and, according to the present invention, a peptide or a protein containing modification such as acylation, glycosylation and phosphorylation can be obtained effectively and at high quality.

    Adrenomedullin
    10.
    发明公开
    Adrenomedullin 失效
    肾上腺髓质素。

    公开(公告)号：EP0622458A2

    公开(公告)日：1994-11-02

    申请号：EP94302948.8

    申请日：1994-04-25

    申请人： SHIONOGI & CO., LTD. ,  Kangawa, Kenji

    发明人： Kitamura, Kazuo ,  Kangawa, Kenji ,  Matsuo, Hisayuki ,  Eto, Tanenao

    IPC分类号： C12N15/16 ,  C07K1/06 ,  C07K7/10 ,  C07K3/02 ,  A61K37/24 ,  C12P21/08 ,  G01N33/74

    CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K1/003 ,  C07K1/107 ,  C07K1/13

    摘要： According to the present invention, adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.

    摘要翻译： 根据本发明，作为具有降血压作用的新型肽的肾上腺髓质素; 对应于具有儿茶酚胺分泌抑制作用的肾上腺髓质素的N末端氨基酸序列的前肾上腺髓质素N-末端20肽（proAM-N20） 提供具有Na通道抑制作用的前肾上腺髓质素N-末端10-20肽（proAM-N（10-20））和编码这些肽的基因。 此外，根据本发明，含有未知量的肾上腺髓质素或proAM-N20的样品中的这些肽可以通过使用针对肾上腺髓质素，proAM-N20或其片段的抗体来定量。